Impaired Fasting Glucose and Chronic Kidney Disease, Albuminuria, or Worsening Kidney Function: A Secondary Analysis of SPRINT

Vieira, Miguel Bigotte; Neves, João Sérgio; Leitão, Luís; Baptista, Rute Baeta; Magriço, Rita; Dias, Catarina Viegas; Oliveira, Ana; Carvalho, Davide; Causland, Finnian R. Mc

doi:10.1210/jc.2019-00073

Cited by 18 publications

(17 citation statements)

References 32 publications

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“…For some years, evidence for a correlation between an increased risk of chronic kidney disease (CKD) and diabetic kidney disease (DKD) in prediabetes has been recorded [ 35 , 46 ]. Characteristic features found in 14 cohort studies are summarized in Table 2 [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Half of the studies [ 48 , 49 , 50 , 51 , 52 , 53 , 54 ] were designed mainly to assess the relationship between metabolic syndrome and CKD.…”

Section: Methodsmentioning

confidence: 99%

“…The size of groups in the presented cohorts ranged from 2398 to 118,924. The European population [ 55 , 56 , 58 ] and the American population [ 47 , 48 , 50 ] were each assessed in three studies, while eight studies concerned the Asian population [ 49 , 51 , 52 , 53 , 54 , 57 , 59 , 60 ]. Some of the European and American studies included multi-ethnic populations, but the white population constituted at least 50% in each of them.…”

Section: Methodsmentioning

confidence: 99%

“…In eight studies, estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73 m 2 was assumed when defining CKD in line with Modification of Diet in Renal Disease (MDRD); in four studies, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) was used, and single studies employed Cockroft–Gault equation [ 50 ], or isotope dilution mass spectrometry traceable 4-variable Modification of Diet in Renal Disease (IDMS-MDRD study equation) [ 57 ]. Five studies additionally included microalbuminuria or proteinuria in the definition of CKD [ 49 , 50 , 53 , 57 , 58 ]. The degree to which the co-variables were adapted differed in particular studies; only six studies included the baseline eGFR [ 47 , 52 , 55 , 57 , 59 , 60 ].…”

Section: Methodsmentioning

confidence: 99%

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Chronic Microvascular Complications in Prediabetic States—An Overview

Baranowska-Jurkun

Matuszewski

Bandurska-Stankiewicz

2020

JCM

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A prediabetic state is a major risk factor for the development of diabetes, and, because of an identical pathophysiological background of both conditions, their prevalence increases parallelly and equally fast. Long-term hyperglycemia is the main cause inducing chronic complications of diabetes, yet the range of glucose levels at which they start has not been yet unequivocally determined. The current data show that chronic microvascular complications of diabetes can be observed in patients with abnormal glucose metabolism in whom glycaemia is higher than optimal but below diagnostic criteria for diabetes. Prediabetes is a heterogenous nosological unit in which particular types are differently characterized and show different correlations with particular kinds of complications. Analysis of the latest research results shows the need to continue studies in a larger population and can imply the need to verify the currently employed criteria of diagnosing diabetes and chronic complications of diabetes in people with prediabetes.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Chronic Microvascular Complications in Prediabetic States—An Overview

Baranowska-Jurkun

Matuszewski

Bandurska-Stankiewicz

2020

JCM

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“…The KORA study suggested that FPG, 2hPG and HbA 1c were all associated with CKD 15 ; however, studies from China, Japan and Korea indicated that it was elevated HbA 1c or impaired glucose tolerance (IGT), but not impaired fasting glucose (IFG) increased the risk for CKD, [18][19][20] and one study based on the Systolic Blood Pressure Intervention Trial concluded that FPG was not associated with the development of CKD. 21 Therefore, which of these prediabetic glycemic indices is/are genuinely associated with the occurrence of CKD remain unclear.…”

Section: What Are the New Findings?mentioning

confidence: 99%

Risk of chronic kidney disease defined by decreased estimated glomerular filtration rate in individuals with different prediabetic phenotypes: results from a prospective cohort study in China

Wang

Jiang

et al. 2020

BMJ Open Diab Res Care

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ObjectiveWe aimed to investigate the effects of prediabetes and its phenotypes of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevated glycated hemoglobin A1c (EHbA1c) on chronic kidney disease (CKD) occurrence, and define the cut-off point of each glycemic index that significantly increases the risk of CKD.Research design and methodsIn this prospective cohort study, 6446 non-diabetic subjects aged 40 years and over were followed over a period of 3 years to track the new onset of CKD. Cox regression was used to assess the association of prediabetes and its phenotypes with CKD. Receiver operating characteristic curves were used to define the cut-off point of each glycemic index that significantly increases the occurrence of CKD. Population attributable risk percent was calculated to estimate the contribution of prediabetes to CKD.ResultsCompared to subjects with normal glucose tolerance, patients with prediabetes significantly increased the risk of development of CKD (HR=2.33 (1.19–4.55)). Specifically, this increased risk of CKD development was observed in patients with IFG, IGT and EHbA1c. The cut-off points shown to significantly increase the risk of CKD are fasting plasma glucose of 5.63 mmol/L, 2-hour plasma glucose of 6.80 mmol/L and HbA1c of 5.6%. The contribution of prediabetes to CKD occurrence in the study population was 60.6%.ConclusionsThis result suggests that the stricter criteria might be needed to define normal plasma glucose level in China that would not be predisposed to diabetic complications, particularly CKD.

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“…However, several studies from Asian reported that elevated HbA1c or PPG, not FPG, presented an increasing risk of kidney disease 15 - 17 . Moreover, one study from the Caucasian concluded that FPG was not associated with the development of kidney disease 18 . Thus, it is discrepant for the association between glycemic indices and renal function and it is not clear that which of glycemic indices presented a close association with increasing risk of renal dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Association between Prediabetes and Renal Dysfunction from a Community-based Prospective Study

Chen

Liu

et al. 2020

Int. J. Med. Sci.

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Objective: Our study aimed to evaluate the association between prediabetes and renal dysfunction, and further assess which of glycemic indices of fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and hemoglobin A1c (HbA1c) has a higher risk of renal dysfunction. Methods: This was a community-based prospective cohort study, which included 7015 participants from Beijing and Taian between May and October in 2015. The outcome was the renal dysfunction defined as estimated glomerular filtration rate (eGFR)<60 mL/min/1.73 m 2 . Univariate and multivariate logistic regression model was performed, and calculated the odds ratio (OR) and 95% confidence interval (95%CI) of renal dysfunction. Receiver operating curve (ROC) analysis was used to predict renal dysfunction for glycemic indices. Results: 121 renal dysfunction cases were identified. We found that the adjusted ORs (95%CI) of renal dysfunction were 1.72 (1.11-2.38), 1.48 (1.09-1.93), 1.97 (1.27-2.89) and 1.35 (1.07-2.13), respectively, for those with prediabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevated HbA1c, compared with individuals with normal glucose tolerance. And IGT presented a higher risk of renal dysfunction than other glycemic indices. The similar results were obtained by performing the subgroup analysis. ROC analysis revealed the PPG had a higher predictive value for renal dysfunction. Conclusion : We found prediabetes was positively associated with the risk of renal dysfunction and PPG had a higher risk and predictive value of renal dysfunction than other glycemic indices of FPG and HbA1c.

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Impaired Fasting Glucose and Chronic Kidney Disease, Albuminuria, or Worsening Kidney Function: A Secondary Analysis of SPRINT

Cited by 18 publications

References 32 publications

Chronic Microvascular Complications in Prediabetic States—An Overview

Chronic Microvascular Complications in Prediabetic States—An Overview

Risk of chronic kidney disease defined by decreased estimated glomerular filtration rate in individuals with different prediabetic phenotypes: results from a prospective cohort study in China

Association between Prediabetes and Renal Dysfunction from a Community-based Prospective Study

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