Impaired facial expression recognition in children with temporal lobe epilepsy: Impact of early seizure onset on fear recognition

Golouboff, Nathalie; Fiori, Nicole; Delalande, Olivier; Fohlen, Martine; Dellatolas, Georges; Jambaqué, Isabelle

doi:10.1016/j.neuropsychologia.2007.12.019

Cited by 68 publications

(89 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data contrast with previous observations that right MTL lesions may lead to greater impairment in recognizing emotional stimuli (12,17,37). However, previous studies focused on the recognition of emotional (especially fearful) faces (12,46).…”

Section: Discussioncontrasting

confidence: 99%

“…We also hypothesized that left and right amygdala lesions might have different effects. Whereas a right MTL lesion may strongly impair the processing of facial expressions due to well-known hemispheric asymmetries in face processing (12,17,37), the left amygdala seems to be more strongly involved in the decoding of emotional cues expressed in speech (13) or speechlike material (3,4,29). In two experiments, we tested brain responses to human vocalizations in general (experiment 1) and to emotional vocalizations embedded in pseudolanguage (experiment 2) (Fig.…”

Section: Significancementioning

confidence: 99%

See 1 more Smart Citation

Asymmetrical effects of unilateral right or left amygdala damage on auditory cortical processing of vocal emotions

Frühholz

Hofstetter

Cristinzio

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

We tested whether human amygdala lesions impair vocal processing in intact cortical networks. In two functional MRI experiments, patients with unilateral amygdala resection either listened to voices and nonvocal sounds or heard binaural vocalizations with attention directed toward or away from emotional information on one side. In experiment 1, all patients showed reduced activation to voices in the ipsilesional auditory cortex. In experiment 2, emotional voices evoked increased activity in both the auditory cortex and the intact amygdala for right-damaged patients, whereas no such effects were found for left-damaged amygdala patients. Furthermore, the left inferior frontal cortex was functionally connected with the intact amygdala in right-damaged patients, but only with homologous right frontal areas and not with the amygdala in left-damaged patients. Thus, unilateral amygdala damage leads to globally reduced ipsilesional cortical voice processing, but only left amygdala lesions are sufficient to suppress the enhanced auditory cortical processing of vocal emotions.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Significancementioning

confidence: 99%

Asymmetrical effects of unilateral right or left amygdala damage on auditory cortical processing of vocal emotions

Frühholz

Hofstetter

Cristinzio

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…For example, impaired functioning of the amygdala is implicated with early onset epilepsy, while amygdaloid damage is found in up to 60% of patients with intractable TLE (eg. Golouboff, 2008;Salmenperä, Kalviainen, Partanen, & Pitkanen, 2001). Early onset epilepsy favours the right hemisphere if onset is before 5 years of age, and right amygdala damage reveals greater deficits in regard to social-emotional processing and decision making in males than females ).…”

Section: Amygdalamentioning

confidence: 99%

“…However, in contrast to such evidence, there was a non-significant trend for impaired ability to identify emotion in those with recent onset of epilepsy. Dysfunctional amygdalae are associated with early onset, male gender, and right-sided epilepsy (Golouboff, 2008;Doherty et al, 2003;Salmenperä et al, 2001;McClelland et al, 2006;Hlobil et al, 2008). Early onset epilepsy and male gender were under represented, while right-sided epilepsy was well-represented in in the epilepsy sample.…”

Section: Findings From Main Experimentsmentioning

confidence: 99%

Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

View full text Add to dashboard Cite

“…4 Studies report aberrant face processing mechanisms 5 and gaze direction and emotion recognition deficits. 6,7 Patients often present with broader neurocognitive dysfunction, attributed to a generalized impact of early onset on neurodevelopment, 8 and impairment is often found across different patient groups when compared with healthy controls. Few studies have addressed the link between social perceptual skills and behavioural difficulties.…”

Section: Introductionmentioning

confidence: 99%

Social attention in children with epilepsy

Lunn

Donovan

Litchfield

et al. 2017

Brain and Cognition

View full text Add to dashboard Cite

Children with epilepsy may be vulnerable to impaired social attention given the increased risk of neurobehavioural comorbidities. Social attentional orienting and the potential modulatory role of attentional control on the perceptual processing of gaze and emotion cues have not been examined in childhood onset epilepsies. Social attention mechanisms were investigated in patients with epilepsy (n = 25) aged 8-18 years old and performance compared to healthy controls (n = 30). Dynamic gaze and emotion facial stimuli were integrated into an antisaccade eye-tracking paradigm. The time to orient attention and execute a horizontal saccade toward (prosaccade) or away (antisaccade) from a peripheral target measured processing speed of social signals under conditions of low or high attentional control. Patients with epilepsy had impaired processing speed compared to healthy controls under conditions of high attentional control only when gaze and emotions were combined meaningfully to signal motivational intent of approach (happy or anger with a direct gaze) or avoidance (fear or sad with an averted gaze). Group differences were larger in older adolescent patients. Analyses of the discrete gaze emotion combinations found independent effects of epilepsy-related, cognitive and behavioural problems. A delayed disengagement from fearful gaze was also found under low attentional control that was linked to epilepsy developmental factors and was similarly observed in patients with higher reported anxiety problems. Overall, findings indicate increased perceptual processing of developmentally relevant social motivations during increased cognitive control, and the possibility of a persistent fear-related attentional bias. This was not limited to patients with chronic epilepsy, lower IQ or reported behavioural problems and has implications for social and emotional development in individuals with childhood onset epilepsies beyond remission.

show abstract

Impaired facial expression recognition in children with temporal lobe epilepsy: Impact of early seizure onset on fear recognition

Cited by 68 publications

References 106 publications

Asymmetrical effects of unilateral right or left amygdala damage on auditory cortical processing of vocal emotions

Asymmetrical effects of unilateral right or left amygdala damage on auditory cortical processing of vocal emotions

Autistic characteristics in adults with epilepsy

Social attention in children with epilepsy

Contact Info

Product

Resources

About