Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation
Lauren A Buck,
Qiaowei Xie,
Michelle Willis
et al.
Abstract:Substance use disorders (SUDs) are highly comorbid with HIV infection, necessitating an understanding of the interactive effects of drug exposure and HIV. The relationship between progressive HIV infection and cocaine use disorder is likely bidirectional, with cocaine use having direct effects on immune function while HIV infection can alter addiction-related behavior. To better characterized the neurobehavioral and immune consequences of HIV infection and cocaine exposure, this study utilized a humanized mous… Show more
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