Abstract:ESX‐3 is a secretion pathway which is essential for mycobactin‐mediated iron acquisition under iron‐limited conditions. Although present in all Mycobacterium sp., ESX‐3 remains to be elucidated in Mycobacterium abscessus. In the study reported here, impaired ESX‐3 seriously restricts the growth of M. abscesses under iron‐limited conditions; growth is salvaged by functional ESX‐3 or iron supplementation. Notably, impaired ESX‐3 does not kill M. abscesses when environmental iron is insufficient but induces persi… Show more
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