Impaired epididymal function of albino rats infected and treated with Trypanosoma brucei brucei and Trypanosoma congolense

Okpala, Micheal I.; Ezeh, Ikenna O.; Obi, C. F.; Ochiogu, Izuchukwu S.; Obidike, R. I.; Ezeokonkwo, R.C.

doi:10.1007/s00580-019-02983-2

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…The shorter PP in this present study may suggest that the T. brucei isolates used are more virulent thereby increasing its ability to establish infection in the bucks. The clinical signs of rough hair coat, alopecia, pyrexia, ocular discharge epistaxis and progressive anemia are consistent with findings in earlier studies of trypanosomosis (2,3,5,31,32).…”

Section: Discussionsupporting

confidence: 90%

Time-Dependent Testicular and Epididymal Damage in Rabbit Bucks Experimentally Infected with Trypanosoma Brucei Brucei

Adeyeye

Alayande

Adio

et al. 2021

Macedonian Veterinary Review

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This study was designed to determine the progressive pathological changes in the testis and epididymis of rabbit bucks experimentally infected with Trypanosoma brucei brucei (T. brucei). Fifteen local rabbit bucks were divided into 2 groups comprising 8 bucks in group A and 7 bucks in group B. Bucks in group A were infected intraperitoneally with approximately 1.0x106 of T. brucei while bucks in group B served as the uninfected control. The bucks were closely monitored for clinical signs of trypanosomosis from the time of infection till the end of the study. One buck from each group was humanely sacrificed on days 9, 19, 29 and 38 post-infection (pi) and its testis and epididymis were examined for pathological changes. At post mortem, no gross lesions were observed in the infected bucks except for adhesion of the testis and epididymis to the scrotum on days 29 and 38 pi. There were no histological changes in the testis and epididymis of the infected buck sacrificed on day 9 pi apart from mild depletion of the epididymal sperm reserve. The buck infected on day 19 pi had moderate testicular degeneration but the epididymis was devoid of sperm reserve. Severe testicular and epididymal degeneration was observed in the buck on days 29 and 38 pi. The testis and epididymis of bucks from the control group were normal with evidence of spermatogenic activities and full epididymal sperm reserve throughout. The study shows that infected bucks were unfit for breeding from day 19 pi.

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Section: Discussionsupporting

confidence: 90%

Time-Dependent Testicular and Epididymal Damage in Rabbit Bucks Experimentally Infected with Trypanosoma Brucei Brucei

Adeyeye

Alayande

Adio

et al. 2021

Macedonian Veterinary Review

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“…Genital abnormalities that have been observed in female animals included anestrus, irregular estrus cycles, low birth weight, stillbirth, neonatal death, abortion, and premature birth [16][17][18][19] and were associated with vertical transmission through the placenta [20,21]. Whereas in male animals infected with trypanosomes, the abnormalities that have been observed were severe degenerative changes of the genitalia (testis and epididymis), delayed puberty, reduced libido, orchitis, and poor semen characteristics [22][23][24]. Sterility, menstrual disorder, and stillbirth have been reported in humans during trypanosomosis infection [25].…”

Section: Introductionmentioning

confidence: 99%

Genital lesions in cows naturally infected with trypanosomes in Abuja, Nigeria

et al. 2021

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Background and Aim: Different species of trypanosomes have been reported to cause varying degrees of reproductive disorders in pregnant and non-pregnant animals under experimental infections. Information on reproductive disorders and losses in animals naturally infected with trypanosome species are few. This study was carried out to assess the abnormalities in the genital organs (ovaries, oviduct, uterus, cervix, and vagina) of female cattle naturally infected with trypanosomes in and around Abuja, Nigeria. Materials and Methods: Cows showing signs such as emaciation, weakness, or anemia were selected and examined at Gwagwalada and Karu abattoirs, respectively. Venous blood samples were taken from 108 of such animals and screened using standard trypanosome detection methods. The genital organs were also collected and inspected for gross and histopathological lesions in the laboratory. Results: Six (5.55%) out of the 108 animals were positive for trypanosomes; 4 (66.7%) were infected with Trypanosoma vivax and 2 (33.3%) were infected with Trypanosoma congolense. The mean packed cell volume of the infected animals was 22.83%. Grossly, congestion and ecchymotic hemorrhages were observed in the endometrium, myometrium, and cervical submucosa. Mucometra, hydrometra, and pyometra were also seen in the uterus. Histologically, necrosis of the epithelium and endometrial glands accompanied by mononuclear cellular infiltration was observed in the uterus. There was also sloughing of the endometrial epithelium, vascular congestion, and hypertrophy of serosa of the uterus. There was atropy of the granulosa cells, increased numbers of degenerating tertiary follicles, and absence of corpora lutea in the ovary. No gross or histopathological lesions were observed in the fallopian tube and vagina. Conclusion: The lesions observed were restricted to the uterus and ovary of the animals and were less severe when compared to lesions observed under experimental conditions as reported by previous authors.

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Efficacy of combined therapy of Diminaveto® and Intromidium® in albino rats experimentally infected with Trypanosoma brucei brucei

et al. 2021

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Impaired epididymal function of albino rats infected and treated with Trypanosoma brucei brucei and Trypanosoma congolense

Cited by 3 publications

References 17 publications

Time-Dependent Testicular and Epididymal Damage in Rabbit Bucks Experimentally Infected with Trypanosoma Brucei Brucei

Time-Dependent Testicular and Epididymal Damage in Rabbit Bucks Experimentally Infected with Trypanosoma Brucei Brucei

Genital lesions in cows naturally infected with trypanosomes in Abuja, Nigeria

Efficacy of combined therapy of Diminaveto® and Intromidium® in albino rats experimentally infected with Trypanosoma brucei brucei

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