Impaired endothelial function in C-reactive protein overexpressing mice

Teoh, Hwee; Quan, Adrian; Lovren, Fina; Wang, Guilin; Tirgari, Sam; Szmitko, Paul E.; Szalai, Alexander J.; Ward, Michael E.; Verma, Subodh

doi:10.1016/j.atherosclerosis.2008.02.034

Cited by 69 publications

(69 citation statements)

References 33 publications

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“…dothelial nitric oxide synthase (eNOS) activity. [17][18][19][20][21] In addition, CRP downregulates the number of endothelial progenitor cells and cell function in vitro. 22) The long pentraxin PTX3 shares some similarities with CRP, but differs in terms of structural domain, gene organization, cellular and tissue sources, inducing stimuli, and recognized ligands.…”

Section: Discussionmentioning

confidence: 99%

Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein

et al. 2014

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SummaryAn infl ammatory response is a key event for endothelial dysfunction. Pentraxin 3 (PTX3) is an infl ammatory protein produced at infl ammation sites such as leukocytes and vascular endothelial cells. Here, we compared the relationships between endothelial function assessed by fl ow-mediated dilation (FMD), and the levels of plasma PTX3 and highsensitive C-reactive protein (hsCRP), another infl ammatory protein of the pentraxin family.Levels of FMD, PTX3 and hsCRP were measured twice within 6 to 8 months and retrospectively analyzed in 36 patients with coronary artery disease. We examined the associations between the values of FMD and the levels of PTX3 and hsCRP at the fi rst measurement, and between the change ratios (second value/fi rst value) of these parameters.Univariate linear regression analysis showed signifi cantly negative correlations between FMD values and PTX3 and hsCRP levels at the fi rst measurement, and signifi cant associations with taking statins or calcium antagonists. Multivariate linear stepwise regression analysis identifi ed PTX3 levels and taking statins and calcium antagonists as independent factors for endothelial function. The change ratio of FMD correlated more closely with that of PTX3 than of hsCRP (r = -0.446, P = 0.006 versus r = -0.330, P = 0.050). Signifi cantly more patients with decreased FMD values had increased levels of PTX3 than those of hsCRP at the second measurement compared with the fi rst measurement. Furthermore, the ratio of patients with increased PTX3, but not increased hsCRP, was signifi cantly reduced among those with increased, rather than decreased, FMD values.Endothelial dysfunction might be more accurately predicted by plasma PTX3 levels than by serum hsCRP levels. (Int Heart J 2014; 55: 160-164)

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Section: Discussionmentioning

confidence: 99%

Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein

et al. 2014

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“…27,28 Alternatively, such effects may be indirect as studies of transgenic mice have associated CRP with the development of hypertension 29 and perivascular fibrosis. 30 The relationship between CRP genotype and human LVH was investigated for the first time in a study by Mann et al 31 They observed an association between a variant of the CRP gene with exercise-induced LVH in young healthy males, undergoing an identical 12-week physical training program. Homozygosity for the T allele of the CRP þ 1444C4T gene variant was associated with serum CRP levels, which were 0.68 mg l À1 higher than carriers of the C allele.…”

Section: Potential Mechanismsmentioning

confidence: 99%

Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women

2012

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Markers of inflammation have previously been related to left ventricular (LV) hypertrophy (LVH) in uremic and hypertensive patients. The present study investigated inflammatory markers in relation to LV geometry and diastolic function in a population of elderly persons. In the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (1016 men and women 70 years of age), echocardiograms to determine relative wall thickness (RWT), LV mass index (LVMI) and the E/A-ratio were obtained. Based on RWT and LVMI, four geometric subgroups were defined; normal, concentric remodeling, eccentric and concentric LVH. In all, 10 circulating inflammatory markers were measured. Higher levels of high sensitive C-reactive protein (hsCRP) and E-selectin were seen in the three abnormal geometry groups than in the normal group adjusting for gender, body mass index, systolic and diastolic blood pressure and use of antihypertensive medication. Higher level of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1) and P-selectin were only seen in concentric LVH. Levels of tumor necrosis factor-alpha, interleukin-6, l-selectin, monocyte chemotactic protein-1 and leukocyte count did not differ between the LV groups. l-selectin and hsCRP were related to the E/A-ratio. The adhesion molecules; E-selectin, ICAM-1, VCAM-1, P-selectin and hsCRP were elevated in elderly persons with abnormal LV geometry, especially in concentric LVH, after adjusting for hypertension and obesity. l-selectin and hsCRP were related to LV diastolic function. Further studies are motivated to investigate a pathogenetic role of inflammation for abnormal LV geometry and function.

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“…metabolic syndromeMetS) is now recognized to play a critical role in the initiation and progression of atherosclerotic vascular disease (Al-Quasi et al, 2008;Bakker et al, 2009;Lamon & Hajjar, 2008). CRP, which levels raise during inflammation contributes to the induction of endothelial cell activation and dysfunction (Deveraj et al, 2010;Grad et al, 2007;Schwartz et al, 2007;Teoh et al, 2008;Venogupal et al, 2003). Patients with MetS have increased plasma levels of oxLDL (Holvoet et al, 2004) and recently it was found that CRP promotes increased oxLDL uptake by vessel wall and cholesterol ester accumulation in Wistar rats (Singh et al, 2008).…”

Section: Wwwintechopencommentioning

confidence: 99%

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

Bucová¹

2011

Angina Pectoris

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Impaired endothelial function in C-reactive protein overexpressing mice

Cited by 69 publications

References 33 publications

Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein

Plasma Pentraxin 3 is a More Potent Predictor of Endothelial Dysfunction than High-Sensitive C-Reactive Protein

Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

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