Impaired Endothelial Function in Adolescents with Type 1 Diabetes Mellitus

Mahmud, Farid H.; Uum, Stan Van; Kanji, Nimira; Thiessen-Philbrook, Heather; Clarson, Cheril

doi:10.1016/j.jpeds.2007.08.044

Cited by 40 publications

(30 citation statements)

References 32 publications

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“…322 Few data are available in children, although with the use of this technique, abnormalities have been found in children with congenital central hypoventilation syndrome, 323 obstructive sleep apnea, 324 and type 1 diabetes mellitus. 325,326 Although this device shows promise and appears to be relatively operator independent, with good reproducibility in children, 325 a single finger cuff size may limit its usefulness in smaller children.…”

Section: Variability and Limitationsmentioning

confidence: 99%

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

Urbina

Williams²,

Alpert³

et al. 2009

Hypertension

555

274

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Abstract-Deterioration in endothelial function and arterial stiffness are early events in the development of cardiovascular diseases. In adults, noninvasive measures of atherosclerosis have become established as valid and reliable tools for refining cardiovascular risk to target individuals who need early intervention. With limited pediatric data, the use of these techniques in children and adolescents largely has been reserved for research purposes. Therefore, this scientific statement was written to (1) review the current literature on the noninvasive assessment of atherosclerosis in children and adolescents, (2) make recommendations for the standardization of these tools for research, and (3) stimulate further research with a goal of developing valid and reliable techniques with normative data for noninvasive clinical evaluation of atherosclerosis in pediatric patients. Precise and reliable noninvasive tests for atherosclerosis in youth will improve our ability to estimate future risk for heart attack and stroke. Currently, large longitudinal studies of cardiovascular risk factors in youth, such as the Bogalusa and Muscatine studies, lack sufficient adult subjects experiencing hard outcomes, such as heart attack and stroke, to produce meaningful risk scores like those developed from Framingham data.

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Section: Variability and Limitationsmentioning

confidence: 99%

Noninvasive Assessment of Subclinical Atherosclerosis in Children and Adolescents

Urbina

Williams²,

Alpert³

et al. 2009

Hypertension

555

274

View full text Add to dashboard Cite

show abstract

“…We used PAT to assess endothelial function, which focuses on small resistance vessels to evaluate endothelium-dependent flow mediated dilation. This method which evaluates endothelial cell response to mechanical stress (reactive hyperemia) to test for the presence of impaired endothelial function as a systemic disorder has been evaluated in both adult [23][24][25] and pediatric [26,45] populations. In adults, PAT-HR has been shown to correlate closely with other measures of endothelial dependent dilation (brachial artery ultrasound) as well as direct measures of coronary arterial function [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The measurement of endothelial function can be used as a surrogate marker to assess cardiovascular risk [21][22][23][24]. In prior clinical studies, peripheral arterial tonometry (PAT) testing has been used to measure endothelial function in both high risk adult [25] and pediatric populations [26,27], and lower PAThyperemia ratio (HR) scores have been associated with the presence of coronary artery dysfunction [21,28,29] and cardiovascular risk factors [31]. The primary objective of our pilot study was to evaluate endothelial function, as an early marker of atherosclerosis, in asymptomatic longterm survivors of Hodgkin Lymphoma in comparison to healthy, cancer-free control subjects.…”

Section: Introductionmentioning

confidence: 99%

Impaired vascular function in asymptomatic young adult survivors of Hodgkin Lymphoma following mediastinal radiation

et al. 2010

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Impaired endothelial function was preferentially observed in HLS who received mediastinal radiation, while no difference was observed between the HLS and control groups overall. This finding, assessed using a non invasive test of endothelial function, confirms that mediastinal radiation is an additional cardiovascular risk factor in this young cohort of patients. Further studies of endothelial function in this patient population are warranted.

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“…116 Endothelial dysfunction has been demonstrated in numerous studies in adolescents with T1DM. 96,117 Nonultrasound methods for assessing endothelial function, including peripheral arterial tonometry, 118,119 and laser flow Doppler studies 120 have demonstrated similar case-control differences. Poor endothelial function was associated with higher HbA 1c 121 and poor fitness level 122 but was not related to inflammation.…”

mentioning

confidence: 95%