Impaired emotional categorisation in young people at increased familial risk of depression

Mannie, Zola; Bristow, Greg C.; Harmer, Catherine J.; Cowen, Philip J.

doi:10.1016/j.neuropsychologia.2007.05.016

Cited by 46 publications

(51 citation statements)

References 29 publications

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“…VPP indexed) of emotional information may be slightly enhanced as only with TRP-was the VPP smaller for neutral versus all, but mildly sad, faces. This is somewhat compatible with previous work documenting that non-depressed FH+ versus FHin dividuals were slower at emotional categorization [81] . Transient decreases in 5-HT may have unmasked altered emotional categorization indexed by increased cortical resource allocation to processing emotional stimuli (i.e.…”

Section: Discussionsupporting

confidence: 92%

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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Background: Depression, which is associated with dysfunctional serotonin (5-HT) activity, may be characterized by impaired emotional information processing. This study assessed the effects of acute tryptophan depletion (TRP–), which transiently lowers CNS 5-HT, on the emotion-sensitive vertex positive potential (VPP) and late positive potential (LPP) event-related potentials (ERPs) and mood in individuals with a family history of depression. The VPP and LPP are thought to index the early and later stages of motivated attentional processing, respectively. Method: Within a double-blind balanced design, ERPs were acquired in 18 individuals with a family history of depression (12 females) after TRP– and TRP+ (balanced) treatment while participants were presented with facial expressions (neutral, as well as sad, joy and surprise at 50 and 100% intensity) and responded to surprised faces. Results: TRP– increased total mood disturbance and maintained depression scores. The VPP and LPP were larger to intense versus mild expressions. Enhanced processing of emotional versus neutral faces, as indexed by the VPP, was primarily evident with TRP–. Speeded and enhanced processing of intensely joyful versus mildly sad faces was found with TRP– (VPP indexed). Compared with TRP+, TRP also increased the VPP to mildly joyful faces. Conclusion: Transient 5-HT decreases in individuals with a family history of depression induce subtle changes in early stages of motivated emotional processing, though not in later ones.

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Section: Discussionsupporting

confidence: 92%

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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“…For example, abused children see anger in more facial expressions than do non‐abused age mates. Children of depressed mothers see sadness in more faces than do children of non‐depressed mothers (Joormann, Gilbert, & Gotlib, 2010; Lopez‐Duran, Kuhlman, George, & Kovacs, 2010; Mannie, Bristow, Harmer, & Cowen, 2007). Adolescent girls with conduct disorder do not recognize anger and disgust facial expressions as well as a control group (Fairchild, Stobbe, van Goozen, Calder, & Goodyer, 2010).…”

Section: Discussionmentioning

confidence: 99%

In Building a Script for an Emotion, Do Preschoolers Add Its Cause Before Its Behavior Consequence?

Widen

Russell

2011

Social Development

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An emotion concept is a script in which an emotion event is an ordered sequence of subevents from situational cause through bodily changes to behavioral consequence. As children build a script for each emotion, in what order do they add each subevent? Preschoolers (N = 108, three to five years), were asked to name the protagonist's emotion in stories consisting solely of either a cause or a consequence of one of six emotions. More children correctly inferred happiness, fear, sadness, and disgust from their causes than from their consequences, but more correctly inferred anger from its consequence than from its cause. (No significant difference was found for surprise.) Subevents are added to scripts in a different order for different emotions.

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“…In contrast, studies examining the role of 5-HTTLPR genotype in moderating the link between parental depression and individuals’ ability to recognize facial displays of emotion have yielded more mixed results. For example, in one study, 5-HTTLPR genotype did not moderate the link between family history of depression and young adults’ sensitivity or accuracy in recognizing facial displays of emotion (Mannie, Brostow, Harmer, & Cowen, 2007). However, in another study, adolescents exposed to maternal depression who carried two copies of the 5-HTTLPR S allele were less, rather than more, accurate in labeling emotional faces (particularly angry faces) than adolescents with only one or no copies of the S allele (Jacobs et al, 2011).…”

Section: Support For the Role Of Information-processing Biases As An mentioning

confidence: 99%

Toward an integration of cognitive and genetic models of risk for depression

Gibb

Beevers

McGeary

2013

Cognition & Emotion

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There is growing interest in integrating cognitive and genetic models of depression risk. We review two ways in which these models can be meaningfully integrated. First, information-processing biases may represent intermediate phenotypes for specific genetic influences. These genetic influences may represent main effects on specific cognitive processes or may moderate the impact of environmental influences on information-processing biases. Second, cognitive and genetic influences may combine to increase reactivity to environmental stressors, increasing risk for depression in a gene × cognition × environment model of risk. There is now growing support for both of these ways of integrating cognitive and genetic models of depression risk. Specifically, there is support for genetic influences on information-processing biases, particularly the link between 5-HTTLPR and attentional biases, from both genetic association and gene × environment (G × E) studies. There is also initial support for gene × cognition × environment models of risk in which specific genetic influences contribute to increased reactivity to environmental influences. We review this research and discuss important areas of future research, particularly the need for larger samples that allow for a broader examination of genetic and epigenetic influences as well as the combined influence of variability across a number of genes.

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Impaired emotional categorisation in young people at increased familial risk of depression

Cited by 46 publications

References 29 publications

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

In Building a Script for an Emotion, Do Preschoolers Add Its Cause Before Its Behavior Consequence?

Toward an integration of cognitive and genetic models of risk for depression

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