Impaired coronary blood flow in patients with metabolic syndrome: Documented by Thrombolysis In Myocardial Infarction (TIMI) frame count method

Turhan, Hasan; Erbay, Ali Rıza; Yaşar, Ayşe Saatçı; Biçer, Asuman; Şaşmaz, Hatice; Yetkın, Ertan

doi:10.1016/j.ahj.2004.05.016

Cited by 46 publications

(38 citation statements)

References 35 publications

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“…Many reported studies have used several modalities to investigate the relationship MetS and coronary microvascular circulation. Turhan et al (29) reported an impaired coronary blood flow using the Thrombolysis in Myocardial Infarction frame count method in MetS patients with angiographically normal coronary arteries. Pirat et al (7), using transthoracic echocardiography, have reported an impaired vasodilatory response to pharmacologic agents in the LAD of coronary arteries in patients with MetS.…”

Section: Discussionmentioning

confidence: 99%

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Tok¹,

Özcan²,

Kadife³

et al. 2013

AnadoluKardiyolDerg

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Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational studyMetabolik sendromlu hastalarda ekokardiyografik olarak gösterilen bozulmuş koroner akım rezervi artmış aort sertliği ile ilişkilidir: Gözlemsel bir çalışma ABSTRACTObjective: Metabolic syndrome (MetS) is a strong predictor of cardiovascular events and coronary flow reserve (CFR), an indicator of microvascular function, has been found to be impaired in MetS. Aortic stiffness (AS) is a simple and effective method for assessing arterial elasticity. The aim of this study was to evaluate whether there is an independent association of impaired coronary flow and aortic elasticity in patients with MetS. Methods: Forty-six patients (mean age 47.3±6.6 years) with the diagnosis of MetS according to the ATP III update criteria and 44 age and gender matched controls (mean age 46.0±6.1 years) were included into the cross-sectional observational study. Peak diastolic coronary flow velocities were measured in left anterior descending artery by pulsed wave Doppler at baseline and after adenosine infusion, and CFR was calculated as the ratio of hyperemic to baseline velocities. Aortic strain, distensibility and stiffness were calculated by M-mode echocardiography. Statistical analysis was performed by using Student t-test, Chi-square test, Pearson correlation and linear regression analyses. Results: CFR was significantly lower in patients with MetS than in controls (2.3±0.2 vs 2.7±0.2, p<0.001). In the MetS group, aortic distensibility (10.4±3.5 cm 2 .dyn -1 .10 -6 vs. 12.7±3.4 cm 2 .dyn -1 .10 -6 , p=0.002) was decreased and AS was significantly increased (6.5±2.0 vs. 3.2±0.8, p<0.001). In multivariate linear regression analysis, AS (β=-0.217, p=0.047), systolic blood pressure (β=-0.215, p=0.050) and waist circumference (β=-0.272, p=0.012) had an independent relationship with impaired CFR. Conclusion: This study demonstrated that coronary flow reserve is impaired in patients with MetS and there is an independent relationship between impaired CFR and increased aortic stiffness, systolic blood pressure or waist circumference. (Anadolu Kardiyol Derg 2013; 13: 227-34)

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Section: Discussionmentioning

confidence: 99%

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Tok¹,

Özcan²,

Kadife³

et al. 2013

AnadoluKardiyolDerg

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“…Coronary microvasculature are the major source of coronary vascular resistance due to their small diameters and well--developed media [29]. It was stipulated in a study that the presence of increased TIMI frame counts in patients with MS with angiographically proven normal coronary arteries may be the result of impaired vessel function indicating microvascular dysfunction [12]. The effect of the autonomic nervous system on coronary blood flow and insulin resistance is well known; however, it has not been exactly understood yet whether impaired coronary blood flow occurring in MS arises from endothelial dysfunction or autonomic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…It was also demonstrated that coronary flow rate was decreased in patients with MS [12]. The Thrombolysis in Myocardial Infarction (TIMI) frame count is a simple clinical tool for assessing quantitative indexes of coronary blood flow.…”

Section: Introductionmentioning

confidence: 99%

The association between coronary flow rate and impaired heart rate recovery in patients with metabolic syndrome: A preliminary report

et al. 2014

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Background:The aim of this study is to evaluate heart rate recovery (HRR) (HRR first: 32 ± 9 vs. 37 ± 10; p = 0.01, second: 46 ± 11 vs. 52 ± 11; p = 0.03, third: 51 ± 12 vs. 59 ± 12; p = 0.00, fourth: 54 ± 13 vs. 61 ± 2; p = 0.02). TIMI frame counts for each major epicardial coronary artery and mean TIMI frame count were also found to be significantly higher in MS group compared to controls (left anterior descending artery: 51 ± 24 vs. 39 ± 15; p = 0.009, left circumflex artery: 32 ± 11 vs. 24 ± 7; p = 0.001, right coronary artery: 33 ± 14 vs. 24 ± 10; p = 0.003, mean TIMI frame count: 38 ± 15 vs. 29 ± 9; p = 0.002

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“…A higher TIMI frame count may reflect disordered vessel resistance. [14][15][16] Briefly, the number of cineangiographic frames (recorded at 25 frames/s) required for the leading edge of the column of radiographic contrast to reach a predetermined landmark is determined. The first frame is defined as that in which concentrated dye occupies the full width of the proximal coronary artery lumen, touching both of its borders, and having forward motion down the artery.…”

Section: Evaluation Of Cbfmentioning

confidence: 99%

Improvement of Postprandial Hyperglycemia Has a Positive Impact on Epicardial Flow of Entire Coronary Tree in Acute Coronary Syndromes Patients

Iijima

Nakajima

Sugi

et al. 2007

Circ J

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Impaired coronary blood flow in patients with metabolic syndrome: Documented by Thrombolysis In Myocardial Infarction (TIMI) frame count method

Cited by 46 publications

References 35 publications

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study

The association between coronary flow rate and impaired heart rate recovery in patients with metabolic syndrome: A preliminary report

Improvement of Postprandial Hyperglycemia Has a Positive Impact on Epicardial Flow of Entire Coronary Tree in Acute Coronary Syndromes Patients

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