Background: Adolescent drug and alcohol abuse remains a significant public health concern globally, influencing individual behaviors and family dynamics, and imposing a heavy burden on communities due to its associated risks and consequences. Objective: This study investigates the interplay between personal attributes and family dynamics in adolescent drug addiction, emphasising the need for comprehensive prevention and treatment strategies. Methods: We studied 60 adolescents from high-risk neighbourhoods in Guayaquil, divided into two groups based on their addiction status. Personal factors assessed included emotional stability and cognitive control, while family factors were evaluated using the McMaster Family Assessment Device and other specialised tools to measure family problem-solving and emotional involvement. A combination of Welch t-tests, chi-square tests, and multivariate logistic regression was used to analyse the data. Results: Both groups displayed low scores in cognitive control and emotional stability, with addicted adolescents showing particularly impaired scores. Significant differences were not observed in family functioning between the groups, suggesting similar family dynamics despite differing addiction statuses. However, adolescents with addiction were more likely to have family members also suffering from addiction, indicating possible genetic and environmental influences. The regression analysis identified critical health issues in the family, insufficient family problem-solving skills, and low emotional stability as significant predictors of addiction. Conclusion: The findings underscore the complexity of adolescent drug addiction, influenced by both individual psychological factors and family dynamics. Interventions should address both personal vulnerabilities and family environment to effectively reduce drug addiction rates. Targeted interventions enhancing family problem-solving abilities and supporting emotional stability could be particularly effective. Limitations include the reliance on self-report measures and the cross-sectional nature of the study, which restricts causal inferences. Significance: Understanding the detailed pathways linking personal and familial factors to drug addiction can aid in developing more nuanced and effective prevention strategies tailored to the needs of at-risk adolescents, thereby reducing the broader impact of this urgent public health issue.