“…Recently significant interest has arisen in possible interactions between central mood substrates and circuitries involved in metabolism (Gomez-Pinilla, 2008;Krishnan and Nestler, 2008;Kuperman et al, 2010;McBriar, 2006;Shao et al, 2008). More specifically, several neuropeptides with a clear role in metabolism, such as leptin, ghrelin, orexin, neuropeptide Yand urocortin 3, produce clear anti-depressant-like responses (Eaton et al, 2007;Heilig, 2004;Kuperman et al, 2010;Lu, 2007;Lutter et al, 2008;Yamada et al, 2011), whereas e.g. melanin-concentrating hormone and cholecystokinin evoke a pro-depressant-like phenotype in several rodent models (Becker et al, 2008;Georgescu et al, 2005).…”