Impaired chemoreflex sensitivity during septic shock induced by cecal ligation and perforation

Santiago, Michael Brian; Vieira, Alexandre Antonio; Giusti‐Paiva, Alexandre

doi:10.1139/cjpp-2013-0219

Cited by 4 publications

(2 citation statements)

References 29 publications

(39 reference statements)

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“…It is possible that the baseline sympathetic overactivity is not sufficient to compensate hypotension throughout SI, but it may be useful to induce a pressor response during chemoreflex activation. On the other hand, bradycardic component of the chemoreflex activation was significantly higher during SI, indicating that this mechanism of control of HR is not reduced as documented in shock induced by cecal ligation and perforation [67]. This observation is in line with the hypothesis that even when the baseline parasympathetic drive to the heart is reduced during SI (Fig.…”

Section: Discussionsupporting

confidence: 83%

Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation

Amorim

Deus

Cazuza

et al. 2019

J Neuroinflammation

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Background Lipopolysaccharide (LPS)-induced systemic inflammation (SI) is associated with neuroinflammation in the brain, hypotension, tachycardia, and multiple organs dysfunctions. Considering that during SI these important cardiovascular and inflammatory changes take place, we measured the sensitivity of the cardiovascular reflexes baroreflex, chemoreflex, and Bezold-Jarisch that are key regulators of hemodynamic function. We also evaluated neuroinflammation in the nucleus tractus solitarius (NTS), the first synaptic station that integrates peripheral signals arising from the cardiovascular and inflammatory status. Methods We combined cardiovascular recordings, immunofluorescence, and assays of inflammatory markers in male Wistar rats that receive iv administration of LPS (1.5 or 2.5 mg kg −1 ) to investigate putative interactions of the neuroinflammation in the NTS and in the anteroventral preoptic region of the hypothalamus (AVPO) with the short-term regulation of blood pressure and heart rate. Results LPS induced hypotension, tachycardia, autonomic disbalance, hypothermia followed by fever, and reduction in spontaneous baroreflex gain. On the other hand, during SI, the bradycardic component of Bezold-Jarisch and chemoreflex activation was increased. These changes were associated with a higher number of activated microglia and interleukin (IL)-1β levels in the NTS. Conclusions The present data are consistent with the notion that during SI and neuroinflammation in the NTS, rats have a reduced baroreflex gain, combined with an enhancement of the bradycardic component of Bezold-Jarisch and chemoreflex despite the important cardiovascular impairments (hypotension and tachycardia). These changes in the cardiac component of Bezold-Jarisch and chemoreflex may be beneficial during SI and indicate that the improvement of theses reflexes responsiveness though specific nerve stimulations may be useful in the management of sepsis.

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Section: Discussionsupporting

confidence: 83%

Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation

Amorim

Deus

Cazuza

et al. 2019

J Neuroinflammation

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“…In cecum perforation studies[1-3] the immediate post-perforation threat is rarely studied, particularly regarding: the rapid disappearance of blood vessels in the cecum serosa that are instantly emptied and thereby “disappear”, perforation defect enlargement, bleeding and fluid leakage, increased oxidative stress and disturbed nitric oxide (NO) levels in cecum tissue. Likewise, the possible effect of cytoprotective agents, known to act as a class on endothelium maintenance in the gastrointestinal tract (and, thereby, mucosal maintenance)[4-9], especially the stable gastric pentadecapeptide BPC 157 as a cytoprotective agent rapidly acting on endothelium integrity maintenance[10-19], has been not investigated.…”

Section: Introductionmentioning

confidence: 99%

Counteraction of perforated cecum lesions in rats: effects of pentadecapeptide BPC 157, L-NAME and L-arginine

Drmic¹,

Samara²,

Vidović³

et al. 2018

WJG

118

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AIMTo study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.METHODSAlongside with the agents’ application (after 1 min, medication (/kg, 10 mL/2 min bath/rat) includes: BPC 157 (10 μg), L-NAME (5 mg), L-arginine (100mg) alone or combined, and saline baths (controls)) on the rat perforate cecum injury, we continuously assessed the gross reappearance of the vessels (USB microcamera) quickly propagating toward the defect at the cecum surface, defect contraction, bleeding attenuation, MDA- and NO-levels in cecum tissue at 15 min, and severity of cecum lesions and adhesions at 1 and 7 d.RESULTSPost-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO-levels decreased. BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal. L-NAME: reduced vessel presentation but not more than the control, did not change defect and shortened bleeding. L-arginine: exhibited less vessel reduction, did not change the defect and prolonged bleeding. In combination, mutual counteraction occurred (L-NAME + L-arginine) or the presentation was similar to that of BPC 157 rats (BPC 157 + L-NAME; BPC 157 + L-arginine; BPC 157 + L-NAME + L-arginine), except the defect did not change. Thereby at day 1 and 7, saline, L-NAME, L-arginine and L-NAME + L-arginine failed (defect was still open and large adhesions present).CONCLUSIONThe therapeutic effect was achieved with BPC 157 alone or in combination with L-NAME and L-arginine as it was able to consolidate the stimulating and inhibiting effects of the NO-system towards more effective healing recruiting vessels.

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Dielectric, Photophysical, Solvatochromic, and DFT Studies on Laser Dye Coumarin 334

Maridevarmath¹,

Naik²,

Malimath³

2019

Braz J Phys

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Impaired chemoreflex sensitivity during septic shock induced by cecal ligation and perforation

Cited by 4 publications

References 29 publications

Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation

Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation

Counteraction of perforated cecum lesions in rats: effects of pentadecapeptide BPC 157, L-NAME and L-arginine

Dielectric, Photophysical, Solvatochromic, and DFT Studies on Laser Dye Coumarin 334

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