Impaired Cellular Immunity in Kwashiorkor with Improvement after Therapy

Geefhuysen, J; Rosen, Eric; Katz, J.; T, Ipp; Metz, J

doi:10.1136/bmj.4.5786.527

Cited by 123 publications

(25 citation statements)

References 8 publications

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Section: Discussioncontrasting

confidence: 65%

“…Lymphocytotoxic antibodies could not be incriminated in the majority. One obvious possible cause of depressed CMI in coeliac disease is the nutritional deficiency conse- quent upon the malabsorption, as CMI is known to be depressed in severe malnutrition (Geefhuysen et al, 1971;Smythe et al, 1971 (Waldmann et al, 1972). Although T-cell counts were not performed in this study, reduction in peripheral blood T-cells is unlikely wholly to explain the findings, as the reported magnitude of reduction of T-cell numbers in untreated coeliac disease (O'Donoghue et al, 1975) is considerably less than the magnitude of depression of lymphocyte transformation observed in many of the patients of this study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Depressed cell-mediated immunity in coeliac disease.

Scott¹,

Losowsky²

1976

Gut

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SUMMARY Fourteen coeliac patients on a gluten free diet (GFD) and 10 on a normal diet were studied by lymphocyte transformation in response to PHA to assess the integrity of cell-mediated immunity (CMI). Transformation was depressed in the majority taking a normal diet, with improvement after a GFD. In some patients the depression may have been due to a serum factor, as transformation was more nearly normal when the lymphocytes were cultured in pooled AB serum than in their own serum. There was no correlation between transformation and nutritional deficiencies. Mantoux tests were performed in some of these and other coeliac patients and there was a very significant reduction in the incidence ofpositive tests compared with controls. These findings provide evidence of depressed CMI in coeliac patients taking a normal diet with improvement on a GFD and may be of relevance to the high risk of malignancy in coeliac disease, further strengthening the case for a strict GFD.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Depressed cell-mediated immunity in coeliac disease.

Scott¹,

Losowsky²

1976

Gut

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show abstract

“…While impaired lymphocyte reactions can be acquired with marasmus (Geefhuysen et al, 1971) complete abrogation is unrecorded. The appearance of some detectable serum IgM is also recorded in several other patients with combined immune deficiency (Hobbs, 1969) as is the late onset.…”

Section: Discussionmentioning

confidence: 99%

Uncomplicated HL-A Matched Sibling Bone Marrow Graft for Combined Immune Deficiency

Yamamura¹,

Newton²,

James³

et al. 1972

BMJ

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“…The mechanism by which such large numbers of Candida become established in malnourished children is not clear. Previous studies have shown the ability of such children to secrete intestinal immunoglobulins to be unimpaired (Bell et al, 1976), while depression of cell-mediated immunity in vivo and in vitro has been reported in malnutrition (Geefhuysen et al, 1971;Chandra, 1972;Ferguson et al, 1974). However Kulapongs et al (1974) found lymphocyte responsiveness to phytohaemagglutinin and killing ability of polymorphs to be normal in a group of malnourished children with iron deficiency, while Macdougall et al (1975) found cell-mediated immunity was impaired in such children.…”

mentioning

confidence: 97%