Impaired CD4 T-cell Response to SARS-CoV-2: Rationale for PD-1 Blockade in Patients with Cancer and COVID-19?

Salomé, Bérengère; Horowitz, Amir

doi:10.1158/2159-8290.cd-21-0613

Cited by 11 publications

(13 citation statements)

References 10 publications

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“…Although nocardial brain abscess is commonly secondary to the primary pulmonary site of infection, we couldn’t identify the primary focus in our patient despite a thorough investigation. We assume that the primary infection was subclinical, overshadowed by the CT feature of COVID-19 pneumonia, and masked by a short course of antibiotics that the patient received during the previous hospitalization ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Nocardial brain abscess in a persistently SARS-CoV-2 PCR positive patient with systemic lupus erythematosus

Veličković

Vukičević²,

Spurnić³

et al. 2022

Front. Med.

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Coronavirus disease (COVID-19) in immunocompromised patients represents a major challenge for diagnostics, surveillance, and treatment. Some individuals remain SARS-CoV-2 PCR-positive for a prolonged period. The clinical and epidemiological significance of this phenomenon is not well understood. We report a case of a patient with a history of systemic lupus erythematosus (SLE) who has been persistently SARS-CoV-2 PCR positive for 9 months, with multiple thromboembolic complications, and development of nocardial brain abscess successfully treated with surgery and antibiotics.

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Section: Discussionmentioning

confidence: 99%

Case report: Nocardial brain abscess in a persistently SARS-CoV-2 PCR positive patient with systemic lupus erythematosus

Veličković

Vukičević²,

Spurnić³

et al. 2022

Front. Med.

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“…revealed the pathogenic roles of CCR4 + and CCR6 + T FH cells in COVID-19 patients ( Fenoglio et al., 2021 ). Moreover, it is necessary to pay additional attentions to COVID-19 patients who also suffer from other diseases associated with T FH cell responses, like HIV-infection, autoimmune diseases and cancers treated with immune checkpoint blockade (ICB) therapies ( Picchianti-Diamanti et al., 2021 ; Riou et al., 2021 ; Salomé and Horowitz, 2021 ).…”

Section: Virus-specific T Fh Cells In Covid-19mentioning

confidence: 99%

The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells

Wang

Qin²,

Ye³

2022

Front. Cell. Infect. Microbiol.

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Upon acute viral infection, virus-specific CD4+ T cells differentiate into either TH1 cells or follicular helper T (TFH) cells. The molecular pathways governing such bimodal cell fate commitment remain elusive. Additionally, effector virus-specific TFH cells further differentiate into corresponding memory population, which confer long-term protection against re-infection of same viruses by providing immediate help to virus-specific memory B cells. Currently, the molecular mechanisms underlying the long-term maintenance of memory TFH cells are largely unknown. In this review, we discuss current understanding of early differentiation of virus-specific effector TFH cells and long-term maintenance of virus-specific memory TFH cells in mouse models of viral infection and patients of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

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“…Preexisting and newly generated CD4+ T-cell responses to SARS-CoV-2 were both impaired in patients with cancer (Salomé and Horowitz, 2021). A multicenter study (Sereno et al, 2021) suggested that prolonged granulocyte-colony stimulating factor (G-CSF) treatment was associated with a worse outcome in cancer patients with neutropenia and COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Continuous care needs in patients with cancer receiving chemotherapy during the recent omicron wave of COVID-19 in Shanghai: A qualitative study

et al. 2023

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AimsThis study aimed to investigate the care needs, to clarify the factors affecting the quality of homecare, and to provide reference for constructing a homecare system for patients with cancer receiving chemotherapy during the recent omicron wave of COVID-19 in Shanghai.MethodsFrom March to May 2022 when the omicron wave emerged in Shanghai, 50 consecutive patients who received chemotherapy at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, were enrolled, and underwent face-to-face or telephone-based semi-structured interviews regarding continuous care needs. Some of their homecare-givers, caring nurses, and physicians were also interviewed. The Colaizzi method was used for data analysis.ResultsFifty patients, 4 homecare-givers, 4 nurses, and 4 physicians were interviewed. Three themes and six subthemes emerged from analysis of the interviews: The first theme was “Disease management needs,” including needs for knowledge of managing adverse events associated with chemotherapy, and needs for treatment-related information. Patients expressed most concern about not being able to go to the hospital for blood review and disease evaluation in time due to the outbreak. With the COVID-19 pandemic being ongoing, factors such as pandemic panic, inconvenient medical treatment, and worry about hospital cross-infection might reduce disease management for patients with cancer. The second theme was “Medical needs,” including needs for mobile healthcare and needs for medical resources. All interviewees emphasized the importance of mobile healthcare during the COVID-19 pandemic, as access to hospitals was difficult. The third theme was “Spiritual needs,” including demands for psychological counseling and intervention, and needs for spiritual care. Patients and homecare-givers commonly lacked a feeling of security and needed communication, encouragement, and reassurance that medical care could be delivered to them, and patients reported that they very much wanted psychological advice.ConclusionFor patients with cancer receiving chemotherapy during the COVID-19 pandemic, continuous care is greatly needed. Medical personnel should strengthen the healthcare education for patients and their caregivers during hospitalization, and further improve the patients’ information intake rate through Internet-based digital healthcare methods during homecare, to further meet the information needs of patients after discharge from hospital.

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Impaired CD4 T-cell Response to SARS-CoV-2: Rationale for PD-1 Blockade in Patients with Cancer and COVID-19?

Abstract: Cancer is a strong risk factor for severe COVID-19 disease. In this issue of Cancer Discovery, Bilich and colleagues demonstrate impaired preexisting and newly generated CD4 T-cell response to SARS-CoV-2 in patients with cancer.

Cited by 11 publications

References 10 publications

Case report: Nocardial brain abscess in a persistently SARS-CoV-2 PCR positive patient with systemic lupus erythematosus

Case report: Nocardial brain abscess in a persistently SARS-CoV-2 PCR positive patient with systemic lupus erythematosus

The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells

Continuous care needs in patients with cancer receiving chemotherapy during the recent omicron wave of COVID-19 in Shanghai: A qualitative study

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