Impaired Carbon Monoxide Diffusing Capacity is the strongest lung function predictor of decline in 12 minute-walking distance in COPD; a 5-year follow-up study

Farkhooy, Amir; Janson, Christer; Arnardóttir, Ragnheiður Harpa; Emtner, Margareta; Hedenström, Hans; Malinovschi, Andreï

doi:10.3109/15412555.2014.948991

Cited by 13 publications

(6 citation statements)

References 46 publications

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“…This is in fact in line with previous findings from our group in which we could demonstrate that in patients suffering from COPD, e.g. airway obstruction, DLCO is more closely linked to reduced walk distance [38]. On the other hand, DLCO/VA was revealed as the main determinant of exercise-induced desaturation, which is in line with reported interdependence between pulmonary diffusion and oxygen desaturation during exercise in patients with diffuse systemic sclerosis and interstitial lung disease [39].…”

Section: Discussionsupporting

confidence: 93%

Lung function in relation to six-minute walk test in pulmonary hypertension

Farkhooy

Bellocchia

Hedenström

et al. 2020

European Clinical Respiratory Journal

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Background: Pulmonary hypertension (PH) is a progressive disorder of the pulmonary circulation, associated with diverse medical conditions. Exercise limitation is the most prominent symptom in PH. Exercise capacity, commonly assessed through a six-minute walk test (6MWT), correlates with both functional status and survival in PH. Few studies have analysed the relation between respiratory function and exercise limitation. Therefore, we investigated the relationship between resting pulmonary function, exercise capacity, and exertional desaturation, assessed through the 6MWT, in unselected PH patients. Methods: Fifty consecutive patients with PH diagnosis, referred for pulmonary function testing (lung volume, spirometry, and diffusing capacity for carbon monoxide (DLCO)

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Section: Discussionsupporting

confidence: 93%

Lung function in relation to six-minute walk test in pulmonary hypertension

Farkhooy

Bellocchia

Hedenström

et al. 2020

European Clinical Respiratory Journal

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“…Moreover, DLCO (%predicted) also correlated with ISWT distance in all groups. A previous study showed similar results, and indicated that DLCO (%predicted) was a good indicator of exercise capacity measured by the ISWT [25].…”

Section: Discussionsupporting

confidence: 70%

Associations between the distance covered in the incremental shuttle walk test and lung function and health status in patients with chronic obstructive pulmonary disease

Ushiki

Nozawa

Matsumura

et al. 2017

Respiratory Investigation

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“…Inspiratory capacity (IC) and inspiratory capacity-to-total lung capacity ratio (IC/TLC) have been shown to be useful measures of lung function, and to be strongly associated with dyspnea 21,22. In addition, the gas transport properties of the lungs, measured using the diffusing capacity of the lung for carbon monoxide (DLCO) has previously also been associated with dyspnea,23 and has been shown to be a strong predictor of longitudinal change in walking distance in COPD 24. As such, it may be descriptive of the physical condition of the COPD patient.…”

Section: Introductionmentioning

confidence: 99%

The effect of comorbidities on COPD assessment: a pilot study

Weinreich

Thomsen

Bielaska

et al. 2015

COPD

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IntroductionPatients with chronic obstructive pulmonary disease (COPD) frequently suffer from comorbidities. COPD severity may be evaluated by the Global initiative for chronic Obstructive Lung Disease (GOLD) combined risk assessment score (GOLD score). Spirometry, body plethysmography, diffusing capacity of the lung for carbon monoxide (DLCO), and high-resolution computed tomography (HR-CT) measure lung function and elucidate pulmonary pathology. This study assesses associations between GOLD score and measurements of lung function in COPD patients with and without (≤1) comorbidities. It evaluates whether the presence of comorbidities influences evaluation by GOLD score of COPD severity, and questions whether GOLD score describes morbidity rather than COPD severity.MethodsIn this prospective study, 106 patients with stable COPD were included. Patients treated for lung cancer were excluded. Demographics, oxygen saturation (SpO2), modified Medical Research Council Dyspnea Scale, COPD exacerbations, and comorbidities were recorded. Body plethysmography and DLCO were measured, and HR-CT performed and evaluated for emphysema and airways disease. COPD severity was stratified by the GOLD score. Correlation analyses: 1) GOLD score, 2) emphysema grade, and 3) airways disease and lung function parameters, described by: forced expiratory volume in the first second in percent of expected value (FEV1%), inspiratory capacity (IC%), total lung volume (TLC%), IC/TLC, and SpO2. Correlation analyses between subgroups and hierarchical cluster analysis were performed.ResultsSignificant associations were found between GOLD score and both emphysema grade (correlation coefficients [cc]: −0.2, P=0.03) and lung function parameters (cc: −0.5 to −0.7, P-values all <0.001) weakened in patients with >1 comorbidity (cc: −0.4 to −0.5, P-values all 0.001). Significant differences between subgroups were found in GOLD score and both FEV1% (cc: −0.2, P=0.02) and IC/TLC (cc: −0.2, P=0.02). Comorbidities were associated with GOLD score and composite measures in hierarchical cluster analysis.ConclusionThe presence of comorbidities influences the relationship between GOLD score and lung function measurements. GOLD score may be more representative of morbidity than of COPD severity.

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Impaired Carbon Monoxide Diffusing Capacity is the strongest lung function predictor of decline in 12 minute-walking distance in COPD; a 5-year follow-up study

Abstract: In a 5-year longitudinal study, DLco-measurements at baseline were the most important predictors of declining exercise capacity in COPD patients. These results suggest that integration of DLco in the clinical workup provides a more comprehensive assessment in patients with COPD.

Cited by 13 publications

References 46 publications

Lung function in relation to six-minute walk test in pulmonary hypertension

Lung function in relation to six-minute walk test in pulmonary hypertension

Associations between the distance covered in the incremental shuttle walk test and lung function and health status in patients with chronic obstructive pulmonary disease

The effect of comorbidities on COPD assessment: a pilot study

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