Impaired Autoregulation of Blood Flow at the Optic Nerve Head During Vitrectomy in Patients With Type 2 Diabetes

Hashimoto, Ryuya; Sugiyama, Tetsuya; Masahara, Hidetaka; Sakamoto, Masashi; Ubuka, Makoto; Maeno, Takatoshi

doi:10.1016/j.ajo.2017.06.021

Cited by 16 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hashimoto et al . reported that MBR-vessel and MBR-tissue were decreased 5 minutes after an IOP elevation but it partially recovered 10 minutes after beginning the IOP elevation in normal control human eyes 35 , 36 . In addition, Kiyota et al .…”

Section: Discussionmentioning

confidence: 96%

Evaluation of optic nerve head blood flow in response to increase of intraocular pressure

Iwase

Akahori

Yamamoto

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The time course of the changes in the optic nerve head (ONH) blood flow in response to changes in the ocular perfusion pressure (OPP) induced by an artificial elevation of the intraocular pressure (IOP) has not been determined. We measured the blood flow, represented by the mean blur rate (MBR), on the ONH determined by laser speckle flowgraphy. The MBR was determined before, during, and after the IOP was elevated by 20 or 30 mmHg by pressure applied on the eye by an ophthalmodynamometer in a total of 27 healthy eyes. For an IOP elevation of 20 mmHg, the percentage reduction in the MBR-vessel was −24.7%, and in the MBR-tissue was −16.0% (P < 0.001). For an IOP elevation of 30 mmHg, the percentage reduction of the MBR-vessel was −35.3% and the MBR-tissue was −24.7% (P < 0.001). During the 30 mmHg IOP elevation for 10 minutes, both the MBR-vessel and MBR-tissue began returning to the baseline level from 1 minute after the beginning of the IOP elevation (P < 0.01, P < 0.05, respectively) and continued returning during the 10 minutes IOP elevation (P < 0.001, P < 0.01, respectively). We conclude that the ONH can autoregulate its blood flow in response to experimental changes in OPP induced by IOP elevations.

show abstract

Section: Discussionmentioning

confidence: 96%

Evaluation of optic nerve head blood flow in response to increase of intraocular pressure

Iwase

Akahori

Yamamoto

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…; Hashimoto et al. ,b) and thigh‐cuff release (Ikemura et al. ) has been used to decrease OPP in humans.…”

Section: Introductionmentioning

confidence: 99%

Optic nerve head blood flow regulation during changes in arterial blood pressure in patients with primary open‐angle glaucoma

Bata

Fondi

Witkowska

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…SFDI results regarding Hb, HbO 2 , and StO 2 inside the wound are consistent with other research on diabetic foot ulcers treated with hyperbaric oxygen therapy, which suggests that a lack of oxygen is a main cause for delayed and non‐healing wounds in diabetes . Blood flow is compromised during diabetes because of damage to blood vessels and hyperglycaemia . We showed that, after only 14 days (Figures ), these changes can be observed using SFDI.…”

Section: Discussionmentioning

confidence: 73%

“…48 Blood flow is compromised during diabetes because of damage to blood vessels and hyperglycaemia. 49 We showed that, after only 14 days (Figures 2-4), these changes can be observed using SFDI. Collectively, the results suggest that SFDI has the potential for predicting "at-risk" tissue associated with diabetes and may have applicability to non-healing foot ulcers.…”

Section: Discussionmentioning

confidence: 73%

Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide‐field imaging and conventional immunohistochemistry assays

Saidian

Lakey

Ponticorvo

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

Major complications of diabetes lead to inflammation and oxidative stress, delayed wound healing, and persistent ulcers. The high morbidity, mortality rate, and associated costs of management suggest a need for non‐invasive methods that will enable the early detection of at‐risk tissue. We have compared the wound‐healing process that occurs in streptozotocin (STZ)‐treated diabetic rats with non‐diabetic controls using contrast changes in colour photography (ie, Weber Contrast) and the non‐invasive optical method Spatial Frequency Domain Imaging (SFDI). This technology can be used to quantify the structural and metabolic properties of in‐vivo tissue by measuring oxyhaemoglobin concentration (HbO2), deoxyhaemoglobin concentration (Hb), and oxygen saturation (StO2) within the visible boundaries of each wound. We also evaluated the changes in inducible nitric oxide synthase (iNOS) in the dermis using immunohistochemistry. Contrast changes in colour photographs showed that diabetic rats healed at a slower rate in comparison with non‐diabetic control, with the most significant change occurring at 7 days after the punch biopsy. We observed lower HbO2, StO2, and elevated Hb concentrations in the diabetic wounds. The iNOS level was higher in the dermis of the diabetic rats compared with the non‐diabetic rats. Our results showed that, in diabetes, there is higher level of iNOS that can lead to an observed reduction in HbO2 levels. iNOS is linked to increased inflammation, leading to prolonged wound healing. Our results suggest that SFDI has potential as a non‐invasive assessment of markers of wound‐healing impairment.

show abstract

Impaired Autoregulation of Blood Flow at the Optic Nerve Head During Vitrectomy in Patients With Type 2 Diabetes

Cited by 16 publications

References 41 publications

Evaluation of optic nerve head blood flow in response to increase of intraocular pressure

Evaluation of optic nerve head blood flow in response to increase of intraocular pressure

Optic nerve head blood flow regulation during changes in arterial blood pressure in patients with primary open‐angle glaucoma

Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide‐field imaging and conventional immunohistochemistry assays

Contact Info

Product

Resources

About