Impaired attention network in temporal lobe epilepsy: A resting FMRI study

Zhang, Zhiqiang; Lu, Guangming; Zhong, Yuan; Tan, Qian; Yang, Zhigen; Liao, Wei; Chen, Zhili; Shi, Jinjie; Liu, Yijun

doi:10.1016/j.neulet.2009.04.040

Cited by 172 publications

(123 citation statements)

References 28 publications

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“…In addition to the abnormal network of epileptic foci described above, RS-fMRI studies have also found decreased functional connectivity in the attentional [53] , perceptual [54] , and default mode networks [55,56] , as well as subcortical regions [57,58] . These results indicate that abnormal synchronization is widespread in mTLE patients.…”

Section: Functional Connectivity Based On Linear Correlationmentioning

confidence: 87%

Resting-state fMRI studies in epilepsy

2012

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Abstract:Epilepsy is a disease characterized by abnormal spontaneous activity in the brain. Resting-state functional magnetic resonance imaging (RS-fMRI) is a powerful technique for exploring this activity. With good spatial and temporal resolution, RS-fMRI is a promising approach for accurate localization of the focus of seizure activity. Although simultaneous electroencephalogram-fMRI has been performed with patients in the resting state, most studies focused on activation.This mini-review focuses on RS-fMRI alone, including its computational methods and its application to epilepsy.

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Section: Functional Connectivity Based On Linear Correlationmentioning

confidence: 87%

Resting-state fMRI studies in epilepsy

2012

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“…31 Abnormal activity in the DMN/DAN may influence the task performances and contribute to the pathogenesis of neuropsychiatric disorders. [32][33][34] In this respect the "ring 20 rhythm" could contribute to the cognitive and behavioral impairments observed in [r (20)] syndrome.…”

Section: ] Syndromementioning

confidence: 99%

Epilepsy‐related brain networks in ring chromosome 20 syndrome: An EEG‐fMRI study

et al. 2014

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SUMMARYObjective: To identify the brain networks that are involved in the different electroencephalography (EEG) abnormalities in patients with ring chromosome 20 [r(20)] syndrome. We hypothesize the existence of both distinctive and common brain circuits for the paroxysmal high voltage sharp waves (hSWs), the seizures, and the slow-wave 3-7 Hz rhythm that characterize this condition. Methods: Thirteen patients with [r(20)] syndrome were studied by means of EEG simultaneously recorded with functional magnetic resonance imaging (EEG-fMRI). EEG traces were reviewed in order to detect the pathologic interictal (hSWs) and ictal activities; the 3-7 Hz theta-delta power was derived using a fast Fourier transform. A group-level analysis was performed for each type of EEG abnormality separately using a fixed-effect model and a conjunction analysis. Finally, a second-level random-effect model was applied considering together the different EEG abnormalities, without distinction between hSW, seizures, or theta-delta rhythms. Results: Subcontinuous theta-delta rhythm was recorded in seven patients, seizures in two, and hSWs in three patients. The main results are the following: (1) the slow-wave rhythm was related to blood oxygen level-dependent (BOLD) increases in the premotor, sensory-motor, and temporoparietal cortex, and to BOLD decrements involving the default mode (DMN) and the dorsal attention networks (DANs); (2) the ictalrelated BOLD changes showed an early involvement of the prefrontal lobe; (3) increases in BOLD signal over the basal ganglia, either for interictal and ictal activities, were observed; (4) a common pattern of positive BOLD changes in the bilateral perisylvian regions was found across the different EEG abnormalities. Significance: The BOLD increment in the perisylvian network and the decrease of the DMN and DAN could be the expression of the [r(20)] syndrome-related cognitive and behavioral deficits. The observed BOLD patterns are similar to the ones detected in other epileptic encephalopathies, suggesting that different epileptic disorders characterized by neurobehavioral regression are associated with dysfunction in similar brain networks.

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“…Bettus et al (2009) found decreased basal functional connectivity in the left hemisphere in patients with LTLE, and in addition, they also observed increased basal functional connectivity within the right hemisphere in the same patient group. Cognitive impairments in patients with TLE have also been correlated with changes in functional connectivity (Vlooswijk et al, 2010;Waites et al, 2006;Zhang et al, 2009). Liao et al (2010) found both increases and decreases in resting-state functional connectivity in patients with TLE; two regions with significant decreases in connectivity displayed a negative correlation with the duration of epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Functional Networks in Temporal-Lobe Epilepsy: A Voxel-Wise Study of Resting-State Functional Connectivity and Gray-Matter Concentration

et al. 2013

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Temporal-lobe epilepsy (TLE) involves seizures that typically originate in the hippocampus. There is evidence that seizures involve anatomically and functionally connected brain networks within and beyond the temporal lobe. Many studies have explored the effect of TLE on gray matter and resting-state functional connectivity in the brain. However, the relationship between structural and functional changes has not been fully explored. The goal of this study was to investigate the relationship between gray matter concentration (GMC) and functional connectivity in TLE at the voxel level. A voxel-wise linear regression analysis was performed between GMC maps and whole-brain resting-state functional connectivity maps to both the left thalamus (Lthal) and the left hippocampus (LH) in a group of 15 patients with left TLE. Twenty regions were found that exhibited GMC decreases linearly correlated with resting-state functional connectivity to either the LH or the Lthal in the patient group only. A subset of these regions had significantly reduced GMC, and one of these regions also had reduced functional connectivity to the LH in TLE compared to the controls. These results suggest a network of impairment in left TLE where more severe reductions in GMC accompany decreases (LH, Lthal, right midcingulate gyrus, left precuneus, and left postcentral gyrus) or increases (LH to right thalamus) in resting functional connectivity. However, direct relationships between these imaging parameters and disease characteristics in these regions have yet to be established.

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Impaired attention network in temporal lobe epilepsy: A resting FMRI study

Cited by 172 publications

References 28 publications

Resting-state fMRI studies in epilepsy

Resting-state fMRI studies in epilepsy

Epilepsy‐related brain networks in ring chromosome 20 syndrome: An EEG‐fMRI study

Functional Networks in Temporal-Lobe Epilepsy: A Voxel-Wise Study of Resting-State Functional Connectivity and Gray-Matter Concentration

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