Impaired antioxidative activity of high-density lipoprotein is associated with more severe acute ischemic stroke

Τζιόμαλος, Κωνσταντίνος; Katrini, Konstantina; Papagianni, Marianthi; Gkolfinopoulou, Christina; Angelopoulou, Stella-Maria; Sofogianni, Areti; Savopoulos, Christos; Hatzitolios, Apostolos; Chroni, Angeliki

doi:10.1016/j.metabol.2019.06.004

Cited by 14 publications

(4 citation statements)

References 18 publications

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“…Clinical studies yield similar results to animal experiments. The increase of MPO level in plasma was associated with the severity of ischemic brain damage in ischemic stroke patients (Palm et al, 2018;Tziomalos et al, 2019). A functional MRI study reported the positive correlation between MPO expression and infarct volume in ischemic stroke rat brains (Breckwoldt et al, 2008).…”

Section: Roles Of Mpo In Ischemic Brain Injury By Mediating Inflammation and Oxidative Stressmentioning

confidence: 99%

Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

Chen

et al. 2020

Front. Physiol.

160

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Oxidative stress and inflammation are two critical pathological processes of cerebral ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and therapeutic target triggering both oxidative stress and neuroinflammation in the pathological process of cerebral ischemia-reperfusion injury. MPO is presented in infiltrated neutrophils, activated microglial cells, neurons, and astrocytes in the ischemic brain. Activation of MPO can catalyze the reaction of chloride and H 2 O 2 to produce HOCl. MPO also mediates oxidative stress by promoting the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), modulating the polarization and inflammation-related signaling pathways in microglia and neutrophils. MPO can be a therapeutic target for attenuating oxidative damage and neuroinflammation in ischemic stroke. Targeting MPO with inhibitors or gene deficiency significantly reduced brain infarction and improved neurological outcomes. This article discusses the important roles of MPO in mediating oxidative stress and neuroinflammation during cerebral ischemia-reperfusion injury and reviews the current understanding of the underlying mechanisms. Furthermore, we summarize the active compounds from medicinal herbs with potential as MPO inhibitors for anti-oxidative stress and anti-inflammation to attenuate cerebral ischemia-reperfusion injury, and as adjunct therapeutic agents for extending the window of thrombolytic treatment. We highlight that targeting MPO could be a promising strategy for alleviating ischemic brain injury, which merits further translational study.

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Section: Roles Of Mpo In Ischemic Brain Injury By Mediating Inflammation and Oxidative Stressmentioning

confidence: 99%

Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

Chen

et al. 2020

Front. Physiol.

160

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“…HDL has important anti‐atherosclerotic functions, including antioxidant effects. Some studies found that impaired HDL antioxidant activity is associated with more severe acute ischemic stroke and may also predict poorer functional outcomes in these patients (Tziomalos et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Predictive factors for early neurological deterioration after intravenous thrombolysis of single subcortical infarction in the territory of the middle cerebral artery

Zhao,

Zhong,

et al. 2023

Brain and Behavior

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IntroductionPatients with a single subcortical infarction (SSI) in the territory of the middle cerebral artery (MCA) often experience early neurological deterioration (END) despite receiving intravenous thrombolytic therapy (IVT). In this study, predictors of END were investigated in patients with SSI in the MCA after IVT.MethodsPatients with SSI in the MCA territory who had received IVT between June 2020 and 2022 were included. END was defined as an increase in the total National Institutes of Health Stroke Scale (NIHSS) score by ≥2 or in the motor NIHSS score by ≥1 within the first 72 h of admission. Patients with proximal (pSSI) and distal SSI (dSSI) were analyzed to determine SSI type‐specific predictors for END.ResultsWe evaluated 174 patients with SSI in the MCA territory who underwent IVT. Multivariable logistic regression analysis showed that pSSI (odds ratio [OR] = 0.242; 95% confidence interval [CI], 0.104–0.564; p = .001), lower high‐density lipoprotein cholesterol (HDL‐C) (OR = 0.150; 95% CI, 0.033–0.682; p = .014), higher blood glucose (OR = 0.858; 95% CI, 0.752–0.979; p = .023), and higher red blood cells count (OR = 1.966; 95% CI, 1.154–3.349; p = .013) were risk factors for END. In patients with pSSI, HDL‐C and blood glucose were associated with END. No variable related to END was found in the dSSI group.ConclusionsThe proportion of END in patients with SSI in the MCA territory after IVT was not low; therefore, pSSI, HDL‐C, blood glucose, and red blood cells should be monitored closely. The frequency and predictors of SSI in the MCA territory differed between pSSI and dSSI.

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“…Therefore, once LDL penetrates a dysfunctional endothelium, high HDL can have an anti-atherosclerotic role [ 23 ]. Other studies have shown that HDL from healthy individuals can stimulate the production of endothelial nitric oxide, reduce the production of endothelial reactive oxygen species, prevent the inflammatory reactions of endothelium, and improve endothelial function [ 24 ]. However, there is evidence that the protective effect of HDL on atherosclerosis will lead to atherosclerosis when the inflammatory process increases.…”

Section: Discussionmentioning

confidence: 99%

Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study

Cheng

Liu

et al. 2021

Lipids Health Dis

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Background Evidence on the relationship between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and carotid plaques remains limited. This study aimed to examine the association between LDL-C/HDL-C and carotid plaques in participants with coronary heart disease (CHD) and to further explore the extent to which a healthy lifestyle reduces the risk of LDL-C/HDL-C-related carotid plaques. Methods This large-scale and multi-centre retrospective study included 9426 CHD patients (aged 35–75 years) between January 1, 2014 and September 30, 2020. The LDL-C/HDL-C values were converted to the following tertiles: lowest (< 2.15), middle (2.15–3), and highest (> 3). Healthy lifestyle-related factors referred to whether or not the participant was a non-smoker and non-drinker. Participants were divided into an unfavourable group (those who did not adhere to healthy lifestyle factors), intermediate (only one unhealthy factor), and favourable (neither of the two unhealthy factors). Logistic regression was used for statistical analyses. Results Of the 9426 participants, 6989 (74.15%) CHD patients had carotid plaques. After adjustment for confounders, each unit increase in the LDL-C/HDL-C was significantly associated with carotid plaques (OR: 1.61; 95%CI: 1.43–1.84; P < 0.001). Multivariate logistic regression revealed that carotid plaques risk for the highest tertile (> 3) was 1.18 times that of the lowest quartile (< 2.15). Compared with an unfavourable lifestyle, an intermediate or a favourable lifestyle was associated with a significant 30% (OR: 0.70; 95%CI: 0.64–0.78; P < 0.001) or 67% (OR: 0.33; 95%CI: 0.29–0.37; P < 0.001) reduction in carotid plaques risk, respectively, among CHD patients with high LDL-C/HDL-C. There were significantly additive and multiplicative interactions between lifestyle and LDL-C/HDL-C with regards to carotid plaques. Conclusion A high LDL-C/HDL-C is associated with a risk of carotid plaques developing in CHD patients. Adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques, especially in relation to the highest LDL-C/HDL-C. Graphical abstract

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Impaired antioxidative activity of high-density lipoprotein is associated with more severe acute ischemic stroke

Cited by 14 publications

References 18 publications

Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

Predictive factors for early neurological deterioration after intravenous thrombolysis of single subcortical infarction in the territory of the middle cerebral artery

Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study

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