Impaired Angiogenic Balance and Suppression of Tumorigenicity in HeLa Cells Chronically Exposed to Interferon-α

Endogenous Inhibitors of Angiogenesis

“…IFN-a reduces urokinase-type plasminogen activator and plasminogen activator inhibitor-1 activity (135) and significantly inhibits MMP-9 enzymatic activity and protein expression (136). IFN-a and IFN-h treatment also inhibits angiogenesis by down-regulation of bFGF expression (137)(138)(139), but other studies suggest that the action of IFN-a is not mediated by bFGF or VEGF (140)(141)(142).…”

Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons

“…42 In tumorimplanted animals, IFN-␣ has shown its efficacy in inhibiting tumor growth and/or vascularization which are accompanied by decreased expression of bFGF and MMP-9. 43,44 In various cell types, IFNs could repress the in vitro production of MMP-9 [45][46][47][48][49] and bFGF, 45,50,51 whereas opposite effects of IFNs were observed on VEGF expression. 45 52,53 In therapy for B-CLL, IFN-␣ achieved a partial response in 25 to 50% of previously untreated B-CLL patients with early-stage disease and with no evidence for a favorable influence on outcome.…”

Molecular Targeted Agents Combined with Chemo-Radiation in the Treatment of Locally Advanced Cervix Cancer

“…In virally infected cells, a link between loss of tumor suppressor genes p53 and pRB, and dysregulation of angiogenesis has been described [20][21][22]. Analysis of angiogenesis inducers and modulators in different stages of cervix cancer has shown that the presence of HPV-16 in human epithelial cells results in a decrease of the anti-angiogenic factors thrombospondin 1 and 2 (TSP-1, TSP-2) and the expression of proangiogenic molecules, such as basic fibroblast growth factors (bFGF), interleukin 8 (IL-8), TGF , tumor necrosis factor (TNF ) and VEGF [23][24][25]. More recently, the expression of E6 and E7 proteins in squamous epithelial cells from an HPV16 transgenic mouse model has been associated with early activation of the angiogenic pathway and rapid induction of VEGF in pre-malignant and tumor tissue.…”