Impaired Alcohol Metabolism after Gastric Bypass Surgery: A Case-Crossover Trial

Woodard, Gavitt A.; Downey, John; Hernandez‐Boussard, Tina; Morton, John M.

doi:10.1016/j.jamcollsurg.2010.09.020

Cited by 141 publications

(132 citation statements)

References 23 publications

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“…Methods and baseline data on psychiatric disorders have been reported previously (5). Of note, the SCID screener for alcohol use disorder required reporting having drunk five or more drinks on one occasion, a threshold that might be too high after bariatric surgery given evidence that alcohol pharmacokinetics may be altered by some procedures, thereby decreasing tolerance (20)(21)(22)(23). Lifetime history was assessed at the pre-surgery assessment.…”

Section: Methodsmentioning

confidence: 99%

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Kalarchian

King

Devlin

et al. 2015

Surgery for Obesity and Related Diseases

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Section: Methodsmentioning

confidence: 99%

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Kalarchian

King

Devlin

et al. 2015

Surgery for Obesity and Related Diseases

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“…In two different studies, RYGB patients were their own controls and were given the same dose of alcohol pre-and postoperatively. Increased peak alcohol level and longer time to reach zero concentration were seen postoperatively compared to preoperatively [7,8]. Another possible mechanism that can contribute to an increased alcohol exposure is the decreased contact with gastric mucosa and thereby to the action of gastric alcohol dehydrogenase after RYGB.…”

Section: Discussionmentioning

confidence: 99%

“…Although these effects lead to increased life expectancy and improved quality of life, the operation has also been reported to have side effects [4,5]. RYGB has been reported to cause more rapid and enhanced absorption of alcohol resulting in a faster rise and higher peak blood alcohol concentrations [6][7][8]. In a retrospective population-based cohort study, Östlund et al found that gastric bypass patients postoperatively used more inpatient care for alcohol-related disease compared with patients operated with gastric band or vertical banded gastroplasty [9].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption in Obese Patients Before and After Gastric Bypass as Assessed with the Alcohol Marker Phosphatidylethanol (PEth)

Walther

Brodén²,

Isaksson

et al. 2018

OBES SURG

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Introduction Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. Materials and Methods Two separate consecutive groups of patients and a group of healthy blood donors, as reference group, were included in the study. Alcohol intake was assessed using the alcohol marker phosphatidylethanol (PEth) at preoperative baseline and at 1 and 2 years postoperatively. In the first patient group (n = 133), neither surgeon nor patient was informed about the results of PEth testing. In the second group (n = 214), PEth results above 0.30 μmol/L were considered to indicate excessive alcohol consumption and led to preoperative alcohol counseling. The groups were followed for 2 and 1 year, respectively. Results PEth results were significantly lower in both patient groups at baseline as well as postoperatively compared with the reference group. In both patient groups, there was a significant increase in PEth values at postoperative follow-up compared to baseline. Conclusions Several physiological changes postoperatively have to be considered when interpreting PEth results in obese patients with dramatic weight reductions. According to results for PEth, obese patients treated with bariatric surgery would seem to have lower alcohol consumption compared with the reference group. Although slightly increasing their PEth values postoperatively, the RYGB patients did not reach the PEth values of the reference group.

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“…Aquellos individuos que tienen el antecedente de abuso de alcohol en algún momento de su vida son más propensos a desarrollar este problema después de la cirugía, siendo más frecuente en aquellos sometidos a bypass gástrico en comparación con la banda gástrica 40 . Esta situación se explica debido a alteraciones farmacocinéticas que llevan a un aumento en la absorción del alcohol producto de la cirugía, experimentando sensaciones agradables y embriaguez de manera más precoz y más frecuente, lo cual contribuye a un aumento de la ingesta 41 . En Chile, Maluenda y cols., estudiaron la absorción del alcohol en 12 pacientes pre y post manga gástrica, observándose que la absorción fue considerablemente modificada post cirugía bariátrica, con niveles de alcoholemia más elevados y por más largo tiempo para cantidades equivalentes de alcohol 42 .…”

Section: Uso Problemático De Alcohol Y/o Sustanciasunclassified

Patología Psiquiátrica Y Cirugía Bariátrica

Olguin

2015

Rev Chil Cir

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bariatric surgery and mental disordersMedical treatments have shown poor outcomes, bariatric surgery has become a frequent treatment alternative for obesity. Obese patients seeking treatment have higher psychiatric comorbidity than not consulting ones. Bariatric surgery has allowed a reduction in medical comorbidity and some improvement in pre surgery psychopathology. Recent evidence reports a decrease in depressive disorders rate, improvement in self-esteem and life quality, in direct association with weight reduction, with no significant anxiety changes. Although weight decrease should help to have a better social life, important difficulties in adapting to the new environment can emerge. An increase in suicides and problematic alcohol use has been observed, as well as a decrease in binge eating disorder with further appearance of compensatory behavior, distorted body image, and marital problems. Pre surgery personality disorder could be a risk factor for a negative outcome. In this context a rigorous post surgery follow up is desirable, in order to optimize mental health benefits of massive weight reduction.Key words: Morbid Obesity, bariatric surgery, psychopathology, mental disorders. resumenLos tratamientos médicos de la obesidad han demostrado baja efectividad, lo que ha llevado a que la cirugía bariátrica se haya establecido como una alternativa de tratamiento cada vez más frecuente. Las personas obesas que buscan tratamiento presentan tasas significativamente elevadas de comorbilidades psiquiátricas en comparación con las personas obesas que no consultan. La cirugía bariátrica ha permitido una reducción de las comorbilidades médicas y una mejoría de las patologías psiquiátricas presentes antes de la cirugía. Publicaciones recientes reportan una disminución de los trastornos depresivos, mejoría de la autoestima y de la calidad de vida, directamente asociados a la reducción de peso, sin variaciones significativas en los niveles de ansiedad. Si bien la pérdida de peso debería ayudar al mejoramiento de la vida social del paciente, pueden surgir importantes dificultades para adaptarse al nuevo entorno. Se ha visto un aumento de la tasa de suicidios y del uso problemático de alcohol, disminución precoz del trastorno por atracones con Rev Chil Cir. Vol 67 -nº 4, Agosto; pág. 441-447 artículO de reVisiÓn *Recibido el 5 de noviembre de 2014 y aceptado para publicación el 29 de diciembre de 2014. Conflictos de Interés: ninguno.Correspondencia: Dr.

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Impaired Alcohol Metabolism after Gastric Bypass Surgery: A Case-Crossover Trial

Cited by 141 publications

References 23 publications

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Psychiatric Disorders and weight Change in a Prospective Study of Bariatric Surgery Patients: A 3-Year Follow-Up

Alcohol Consumption in Obese Patients Before and After Gastric Bypass as Assessed with the Alcohol Marker Phosphatidylethanol (PEth)

Patología Psiquiátrica Y Cirugía Bariátrica

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