Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development

Chen, Chih-Tien; Lee, Hsiang-Lin; Chiou, Hui‐Ling; Chou, Chia-Hsuan; Wang, Po-Hui; Yang, Shun‐Fa; Chou, Ying‐Erh

doi:10.1371/journal.pone.0198967

Cited by 12 publications

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“…WISP1 polymorphisms have been identified in various cancers, including breast cancer [ 13 ], urothelial cell carcinoma [ 14 ], hepatocellular carcinoma [ 15 ], oral squamous cell carcinoma [ 16 ], lung cancer [ 17 ], and uterine cervical cancer [ 18 ], but data are scant as to the involvement of WISP1 polymorphisms in gastric cancer. As far as we are aware, our study is the first to investigate the distributions of the rs2929973, rs7843546, and rs10956697 SNPs and their associations with the development of gastric cancer in a Guangxi Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…The WISP1 gene consists of five exons and four introns located on chromosome 8q24.1 to 8q24.3, and it has been shown to be highly polymorphic [ 13 ]. Several clinical studies have indicated a significant association between WISP1 polymorphisms and various cancers, such as breast cancer [ 14 ], urothelial cell carcinoma [ 15 ], hepatocellular carcinoma [ 16 ], oral squamous cell carcinoma [ 17 ], lung cancer [ 18 ] and uterine cervical cancer [ 19 ]. Up until now, to our knowledge, no study has established a connection between WISP1 genetic polymorphisms and gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

et al. 2021

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Background WNT1-inducible signaling pathway protein 1 (WISP1) is a member of the CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression may be involved in carcinogenesis. To date, no studies have investigated the association between single-nucleotide polymorphisms (SNPs) of WISP1 and gastric cancer. Therefore, we conducted this study to explore their relationship. Methods Polymerase chain reaction-restriction fragment length polymorphism assay was used to analyze three SNPs of WISP1 in 204 gastric cancer patients and 227 controls. Results Overall, we could not identify a significant association between WISP1 SNPs and gastric cancer risk. However, the subgroup analysis demonstrated that the presence of the rs7843546 T allele was associated with a significantly decreased risk of gastric cancer in those of Han Chinese ethnicity (CT vs. CC: OR = 0.33, 95%CI 0.14–0.78; TT vs. CC: OR = 0.29, 95%CI 0.11–0.76; CT + TT vs. CC: OR = 0.32, 95%CI 0.14–0.74). In addition, patients with the rs7843546 TT genotype display a 0.34-fold lower risk of developing stage I/II gastric cancer than those with the CC genotype Furthermore, individuals ≥ 50 years old who carried the rs10956697 AC genotype had a significantly decreased risk of gastric cancer (OR = 0.58, 95%CI 0.35–0.98). Smokers with the rs10956697 AC and AC + AA genotypes exhibited a 0.28-fold lower and 0.32-fold lower risk of gastric cancer, respectively. Conclusions The WISP1 SNPs rs7843546 and rs10956697 were, for the first time, found to reduce susceptibility to gastric cancer in various subgroups of Guangxi Chinese.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

et al. 2021

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“…The specimens from oral cancer patients and normal controls were further isolated from the genomic DNA with QIAamp DNA blood mini kits. From the whole blood specimens, the buffy coats were isolated and then the genomic DNA was extracted according to the protocol in previous studies [24][25][26]. The MACC1 rs3095007 (assay IDs: C__27452671_10), rs1990172 (assay IDs: C___2632417_10), rs4721888 (assay IDs: C__27869756_10), rs975263 (assay IDs: C___2632422_20), and rs3735615 (assay IDs: C__27489506_10) SNP was carried out by using the TaqMan™ Genotyping Master Mix on the ABI StepOne™ Real-Time PCR System (Applied Biosystems, Foster City, CA, USA), and the genotypes were determined using SDS software (version 3.0) (Applied Biosystems, Foster City, CA, USA) as in the previous studies [21,27].…”

Section: Macc1 Snp Selection and Dna Extraction And Genotypingmentioning

confidence: 99%

Effect of MACC1 Genetic Polymorphisms and Environmental Risk Factors in the Occurrence of Oral Squamous Cell Carcinoma

Chuang

Lin

et al. 2021

JPM

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MACC1 (Metastasis Associated in Colon Cancer 1) is found to regulate the hepatocyte growth factor (HGF)/Met signal pathway, and plays an important role in tumor proliferation, angiogenesis, and metastasis. However, the relationships between MACC1 SNPs (single nucleotide polymorphisms) and oral cancer are still blurred. In this study, five SNPs (rs3095007, rs1990172, rs4721888, rs975263, and rs3735615) were genotyped in 911 oral cancer patients and 1200 healthy individuals by real-time polymerase chain reaction (PCR), and the associations of oral cancer with the SNP genotypes, environmental risk factors, and clinicopathological characteristics were further analyzed. Our results showed that individuals who had GC genotype or C-allele (GC + CC) in rs4721888 would have a higher risk for oral cancer incidence than GG genotype after adjustment for betel quid chewing, cigarette smoking, and alcohol drinking. Moreover, the 715 oral cancer patients with a betel quid chewing habit, who had C-allele (TC + CC) in rs975263, would have a higher risk for lymph node metastasis. Further analyses of the sequences of rs4721888 revealed that the C-allele of rs4721888 would be a putative exonic splicing enhancer. In conclusion, MACC1 SNP rs4721888 would elevate the susceptibility for oral cancer, and SNP rs975263 would increase the metastasis risk for oral cancer patients with a betel quid chewing habit. Our data suggest that SNP rs4721888 could be a putative genetic marker for oral cancer, and SNP rs975362 may have the potential to be a prognostic marker of metastasis in an oral cancer patient.

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“…The genomic DNA extraction was performed with QIAamp DNA blood mini kits. The buffy coats extracted from the whole blood specimens were used for DNA extraction, and the DNA extraction assay was performed according to previous described [28][29][30]. Extracted DNA was dissolved in Tris-EDTA (TE) buffer and was applied as DNA template in the following process of polymerase chain reactions (PCRs).…”

Section: Sample Preparation and Dna Extractionmentioning

confidence: 99%

Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

et al. 2020

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Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathological characteristics. In this study, real-time polymerase chain reaction was applied to analyze five SNPs of MACC1 rs1990172, rs975263, rs3095007, rs4721888, and rs3735615 in 378 patients with HCC and 1199 cancer-free controls. The results showed that in 151 HCC patients among smokers who carried MACC1 rs1990172 "CA + AA" variants had a lower risk of developing a large tumor (odds ratio [OR] = 0.375, p = 0.026), more advanced clinical stage ([OR] = 0.390, p=0.032), and vascular invasion ([OR] = 0.198, p = 0.034). In 137 HCC patients among drinkers who carried MACC1 rs4721888 "GC + CC" variants had a higher risk to develop vascular invasion ([OR] = 3.780, p = 0.009). Further analyses revealed a statistical significance of aberrant AST/ALT ratio in HCC patients with MACC1 rs975263 "AG+GG" variants before adjustment of age and alcohol drinking. In conclusion, our results suggested that the MACC1 SNPs rs1990172, rs4721888, and rs975263 are involved in HCC progression and clinical characteristics. MACC1 polymorphisms may serve as a marker or a predictor to evaluate HCC progression and prognosis.

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Impacts of WNT1-inducible signaling pathway protein 1 polymorphism on hepatocellular carcinoma development

Cited by 12 publications

References 50 publications

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Effect of MACC1 Genetic Polymorphisms and Environmental Risk Factors in the Occurrence of Oral Squamous Cell Carcinoma

Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

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