Impacts of tumor microenvironment during neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma
Kotaro Sugawara,
Takashi Fukuda,
Chiaki Murakami
et al.
Abstract:With the advent of immune checkpoint inhibitors (ICIs), a better understanding of tumor microenvironment (TME) is becoming crucial in managing esophageal squamous cell carcinoma (ESCC) patients. We investigated the survival impact of TME status and changes in patients with ESCC who underwent neoadjuvant chemotherapy (NAC) followed by surgery (n = 264). We examined immunohistochemical status (CD4+, CD8+, CD20+, Foxp3+, HLA class‐1+, CD204+, and programmed death ligand‐1 [PD‐L1+]) on 264 pre‐NAC and 204 paired p… Show more
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