Impacts of rising temperatures and water acidification on the oxidative status and immune system of aquatic ectothermic vertebrates: A meta-analysis

Messina, Simone; Eens, Marcel

doi:10.1016/j.scitotenv.2023.161580

Cited by 16 publications

(5 citation statements)

References 138 publications

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“…In metamorphosing organisms challenged with pollutants, avoiding an oxidative stress state could allow pre-metamorphic individuals to reach metamorphosis with a body size large enough to reduce post-metamorphic mortality rates (Mccauley et al, 2015; Székely et al, 2020; Zamora-Camacho et al, 2023). Two meta-analyses have suggested that animals show stronger responses to stress at early stages than later in life, which could be a mechanism to avoid developmental impairment and negative carry-over effects (Isaksson, 2010; Messina et al, 2023). However, the evolution of redox responses across an organism’s lifespan may be constrained by its maintaining cost and its relationship with life histories, including phenotypic plasticity (Boonekamp et al, 2018; Burraco et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Martin,

Capilla-Lasheras,

Monaghan

et al. 2023

Preprint

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Among human actions threatening biodiversity, the release of anthropogenic chemical pollutants -which have become ubiquitous in the environment- is a major concern. Chemical pollution can induce oxidative stress and damage by causing the overproduction of reactive oxygen species (ROS), and affecting the antioxidant system. In species undergoing metamorphosis (~80% of all extant animal species), antioxidant responses to chemical pollution may differ between pre- and post-metamorphic stages. Here, we meta-analysed (N = 86 studies, k = 2,012 estimates) the impact of chemical pollution on the redox balance across the three major amphibian life stages (embryo, larva, adult). Before metamorphosis, embryos and larvae activate their antioxidant pathways and do not show increased oxidative damage. In contrast, post-metamorphic individuals show unnoticeable antioxidant responses, and a marked oxidative damage in lipids. Also, type of pollutant (i.e., organic vs inorganic) promotes contrasting effects across amphibian life stages. Our findings show a divergent evolution of the redox balance in response to pollutants across life transitions of metamorphosing amphibians, likely linked to the characteristics of each life stage. Further comparative mechanistic approaches to wildlife responses to global changes will improve our understanding of these eco-evo-devo processes.

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Section: Discussionmentioning

confidence: 99%

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Martin,

Capilla-Lasheras,

Monaghan

et al. 2023

Preprint

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“…In our current study, only SOD activity and TG content showed significant changes in serum, and MDA content in the hepatopancreas also showed significant changes after undergoing 24 h of hightemperature stress at 34 °C, whereas the rest of the various enzyme activity indexes measured in serum and hepatopancreas did not show any significant changes. Fish have been reported to produce large amounts of ROS at high temperatures (Messina et al, 2023). In fish, SOD is the most important system that is used as the first line of defense Frontiers in Physiology frontiersin.org against oxidative stress to remove the ROS that is released as a response to heat stress (Wang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis in hepatopancreases reveals the response of domesticated common carp to a high-temperature environment in the agricultural heritage rice–fish system

Cheng,

Li,

Kumilamba

et al. 2023

Front. Physiol.

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Qingtian paddy field carp (PF-carp) is a local carp cultivated in the paddy field of Qingtian, Zhejiang. This rice–fish co-culture system has been recognized as one of the Globally Important Agriculture Heritage Systems (GIAHS). PF-carp has been acclimatized to the high-temperature environment of shallow paddy fields after several centuries of domestication. To reveal the physiological and molecular regulatory mechanisms of PF-carp, we chose to use 28°C as the control group and 34°C as the treatment group. We measured biochemical parameters in their serum and hepatopancreases and also performed transcriptome sequencing analysis. Compared with the control group, the serum levels of malondialdehyde (MDA), glucose (GLU), glutathione peroxidase (GSH-Px), catalase (CAT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) show no significant change. In addition, superoxide dismutase (SOD), GSH-Px, and CAT also show no significant change in hepatopancreases. We identified 1,253 differentially expressed genes (DEGs), and their pathway analysis revealed that heat stress affected AMPK signaling pathway, protein export, and other biological processes. It is worth noting that protein processing in the endoplasmic reticulum (ER) was the most significantly enriched pathway identified by the Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene set enrichment analysis (GSEA). Significantly higher levels of HSP40, HSP70, HSP90, and other ubiquitin ligase-related genes were upregulated. In summary, heat stress did not lead to tissue damage, inflammation, oxidative stress, and ER stress in the hepatopancreases of PF-carp. This study provides valuable insights into the adaptation mechanism of this species to the high-temperature environment of paddy fields.

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“… Ecoimmunological Assay Immune Parameter Quantified Functional Assay Differentiation of Quantity and Function of Molecules/Cells Direct Interaction with Microbes General or Taxa-Specific References (Examples) Antibody titers (ELISA) Combined amount and avidity of antibodies (can include induced and NAbs) No No No Vertebrate [ 47 ] Quantification of other molecules (cytokines/antioxidants/antimicrobial peptides, etc.) Levels of proteins with immune-support No No No General [ 17 , 49 , 50 ] Differential immune cell count Cells in interstitial fluid/blood No No No General [ 51 , 52 ] Red blood cell agglutionation/lysis Antimicrobial proteins: complement, NAbs, lysozyme, acute phase proteins, others Yes No No Predominantly used in vertebrates [ 53 ] PHA-induced inflammation …”

Section: Considerations For Research Designmentioning

confidence: 99%

Quantification of Thermal Acclimation in Immune Functions in Ectothermic Animals

Sandmeier

2024

Biology

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This short review focuses on current experimental designs to quantify immune acclimation in animals. Especially in the face of rapidly changing thermal regimes, thermal acclimation of immune function has the potential to impact host–pathogen relationships and the fitness of hosts. While much of the field of ecoimmunology has focused on vertebrates and insects, broad interest in how animals can acclimate to temperatures spans taxa. The literature shows a recent increase in thermal acclimation studies in the past six years. I categorized studies as focusing on (1) natural thermal variation in the environment (e.g., seasonal), (2) in vivo manipulation of animals in captive conditions, and (3) in vitro assays using biological samples taken from wild or captive animals. I detail the strengths and weaknesses of these approaches, with an emphasis on mechanisms of acclimation at different levels of organization (organismal and cellular). These two mechanisms are not mutually exclusive, and a greater combination of the three techniques listed above will increase our knowledge of the diversity of mechanisms used by animals to acclimate to changing thermal regimes. Finally, I suggest that functional assays of immune system cells (such as quantification of phagocytosis) are an accessible and non-taxa-specific way to tease apart the effects of animals upregulating quantities of immune effectors (cells) and changes in the function of immune effectors (cellular performance) due to structural changes in cells such as those of membranes and enzymes.

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Impacts of rising temperatures and water acidification on the oxidative status and immune system of aquatic ectothermic vertebrates: A meta-analysis

Cited by 16 publications

References 138 publications

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

Transcriptome analysis in hepatopancreases reveals the response of domesticated common carp to a high-temperature environment in the agricultural heritage rice–fish system

Quantification of Thermal Acclimation in Immune Functions in Ectothermic Animals

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