Impacts of maternal separation stress on ethanol-related responses, anxiety- and depressive-like behaviors in adolescent mice

Favoretto, Cristiane Aparecida; Bertagna, Natalia Bonetti; Righi, Thamires; Rodolpho, Ben Tagami; Anjos-Santos, Alexia; Silva, Flávio Alves da; P, Bianchi; Cruz, Fábio C.

doi:10.1016/j.neulet.2023.137295

Cited by 2 publications

(1 citation statement)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal separation (MS) is a classic animal model of IBS, which effectively mimics ELS ( Riba et al, 2018 ; Wong et al, 2019 ; Huang S. T. et al, 2021 ; Tao et al, 2022a ). Using MS model, some of the pathogeneses of IBS were widely studied, such as visceral hypersensitivity ( Wu et al, 2020 ; Huang S. T. et al, 2021 ; Wang et al, 2022 ; Tao et al, 2022a ), intestinal hyperpermeability ( Kuti et al, 2020 ; Torres-Maravilla et al, 2022 ), intestinal dysmotility ( Bülbül and Sinen, 2021 ), intestinal dysbiosis ( Rincel and Darnaudéry, 2020 ; Park et al, 2021 ), and anxiety-like and depressive-like behaviors ( Zhou et al, 2022 ; Favoretto et al, 2023 ). Also, Riba et al ( Riba et al, 2018 ) systematically studied the influence of MS on the function of the intestine, mimicking IBS’s main features, including intestinal hyperpermeability, visceral hypersensitivity, microbiota dysbiosis, bile acid malabsorption, and low grade inflammation in the intestine.…”

Section: Introductionmentioning

confidence: 99%

Early life stress induces irritable bowel syndrome from childhood to adulthood in mice

Tao,

Wu,

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorder. Traditionally, early life stress (ELS) is predisposed to IBS in adult. However, whether ELS induces IBS in early life remains unclear.MethodsSeparated cohort studies were conducted in neonatal male pups of C57BL/6 mice by maternal separation (MS) model. MS and non-separation mice were scheduled to be evaluated for prime IBS-phenotypes, including visceral hypersensitivity, intestinal motility, intestinal permeability, and anxiety-like behavior. Ileal contents and fecal samples were collected and analyzed by 16S rRNA gene sequencing and bacterial community analyses. Subcellular structures of intestinal epithelial, such as epithelial tight junctions and mitochondria, were observed under transmission electron microscopy.ResultsMS induced visceral hypersensitivity and decreased total intestinal transit time from childhood to adulthood. In addition, MS induced intestinal hyperpermeability and anxiety-like behavior from adolescence to adulthood. Besides, MS affected intestinal microbial composition from childhood to adulthood. Moreover, MS disrupted intestinal mitochondrial structure from childhood to adulthood.ConclusionThe study showed for the first time that MS induced IBS from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and the significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progress of IBS from early life to adulthood.

show abstract