Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria

Feng, Z. Vivian; Gunsolus, Ian L.; Qiu, Tian A.; Hurley, Katie R.; Nyberg, Lyle H.; Frew, Hilena; Johnson, Kyle; Vartanian, Ariane; Jacob, Lisa; Lohse, Samuel E.; Torelli, Marco D.; Hamers, Robert J.; Murphy, Catherine J.; Haynes, Christy L.

doi:10.1039/c5sc00792e

Cited by 205 publications

(190 citation statements)

References 50 publications

(77 reference statements)

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“…Positively charged nanoparticles have better bactericidal activity than negative ones as they can attach more efficiently to the negatively charged bacterial cell wall. Both gram-negative and gram-positive bacteria surface are negatively charged due to the presence of lipoteichoic acid (in grampositive) and lipopolysaccharide (in gram-negative) [38]. Results of our study also clearly showed that FTN with less negatively charge had better bactericidal activity than negatively charged HTN.…”

Section: Discussionsupporting

confidence: 58%

Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents

Masoudi

Mashreghi

Goharshadi

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Theranostic nanoparticles have attracted considerable attention in recently revolutionized medicine. Since the last decade, there has been a growing attempt to design various theranostic nanoparticles but difficulties still exist in the fabrication of their biocompatible one. Herein, fluorescent titania nanoparticles (FTN) were fabricated using a one-step green method. This FTN had ultra-high doxorubicin hydrochloride (DOX) loading capacity (encapsulation efficiency 95.50% and loading content 38.20%) that release the loaded drug in response to acidic pH. In vitro cytotoxicity experiments on human osteosarcoma (SaOs-2) and breast cancer (MCF-7) cell lines revealed superior anticancer efficacy (lowered the IC concentration by 3- and 5.5-fold for SaOs-2 and MCF-7 cells, respectively) and also better imaging for intracellular tracking of DOX/FTN relative to free DOX. Furthermore, the prepared nanoparticles showed efficient antibacterial activity against both gram-negative (Escherichia coli ATCC 25922) and gram-positive (Staphylococcus aureus ATCC 25923) bacteria. In this study, we have developed novel theranostic titania nanoparticles with inherent fluorescence property for cancer imaging and therapy.

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Section: Discussionsupporting

confidence: 58%

Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents

Masoudi

Mashreghi

Goharshadi

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…In the case of nanomaterials comprising polycations (e.g., chitosan and its derivatives) that exhibit a positively-charged surface, the main driving force for their interaction with bacteria is electrostatic in nature [4][5][6]. Other nanomaterials bearing a positively-charged surface, such as diamond nanoparticles, bind closely to the surface of bacteria [7].…”

Section: Introductionmentioning

confidence: 99%

An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

Qin

Engwer

Desai

et al. 2017

Colloids and Surfaces B: Biointerfaces

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Highlights Chitosan-coated nanocapsules, but not nanoemulsions, influence the -potential of E.coli  A fixed number of nanocapsules binds and promotes aggregation of bacteria  In silico simulations agree closely with experimental results  Chitosan-coated nanocapsules attenuate the bacterial quorum sensing response § These authors contributed equally to this publication * Author for correspondence Colloids and Surfaces B: Biointerfaces 149 (2017) 358-368 AbstractWe examined the interaction between chitosan-based nanocapsules (NC), with average hydrodynamic diameter ~114-155 nm, polydispersity ~0.127, and -potential ~+50 mV, and an E. coli bacterial quorum sensing reporter strain. Dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) allowed full characterization and assessment of the absolute concentration of NC per unit volume in suspension. By centrifugation, DLS, and NTA, we determined experimentally a "stoichiometric" ratio of ~80 NC/bacterium. By SEM it was possible to image the aggregation between NC and bacteria. Moreover, we developed a custom in silico platform to simulate the behavior of particles with diameters of 150 nm and -potential of +50 mV on the bacterial surface. We computed the detailed force interactions between NC-NC and NC-bacteria and found that a maximum number of 145 particles might interact at the bacterial surface. Additionally, we found that the "stoichiometric" ratio of NC and bacteria has a strong influence on the bacterial behavior and influences the quorum sensing response, particularly due to the aggregation driven by NC.

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“…Graphene -a two-dimensional single-atom-thick nanomaterial with unique structural, mechanical and electronic properties has potential biomedical applications [52][53][54]. Its high specific surface area allows high-density biofunctionalization for nanotechnology-based drug delivery [55][56][57].…”

Section: Interaction Of Polymers and Nanoparticles With Membranesmentioning

confidence: 99%

Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review

Louis¹

2017

EJB

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Abstract:Although numerous studies have investigated the interaction between nanoparticles and biological systems (proteins, cells, tissues, membrane etc.), and the growing interests of nanotoxicity of these engineered nanoparticles, much remains to be investigated. First, there are various factors to be explored, such as the physical or chemical properties of materials, different cell lines, and the systematic study of specific materials. Secondly, architectural structure (shape) conditions of NPs have not been well investigated and undestood. Third, the variations in cell line result in different cell uptake, toxicity, or transportation in the same materials, but systematic studies of this phenomenon are scanty. Fourth, the nanotoxicity issue and the accumulation of non-degradable materials relating to biosafety are yet to be understood. Fifth, the transformation of NMs' surface chemistry in living creatures is too complicated to investigate. In this article, we review the biophysicochemical mechanisms of the various interactions between nanomaterials and biological systems (proteins, cells, membrane). With the rapid increase in studies related to nanotechnology, investigations on nanomaterials can be more beneficial than others because of their size. A comprehensive understanding of nano-bio interactions can serve as a foundation for future biomedical applications.

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Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria

Abstract: Higher cationic charge density on nanoparticles is correlated with higher toxicity to bacteria.

Cited by 205 publications

References 50 publications

Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents

Multifunctional fluorescent titania nanoparticles: green preparation and applications as antibacterial and cancer theranostic agents

An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

Mechanism, of Biophysicochemical Interactions and Cellular Uptake at the Nano-Bio Interface: A Review

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