Impacts of Endocrine Disrupting Chemicals on Reproduction in Wildlife

Kumar, Emmelianna; Holt, William V.

doi:10.1007/978-1-4939-0820-2_4

Cited by 13 publications

(5 citation statements)

References 91 publications

(81 reference statements)

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“…Fruits and vegetable represent also one of the main human exposure sources to organochlorine pesticides, dangerous compounds related with increased risk of developing several hormonally-related cancers (Lerro et al, 2015). The increasing interest in the determination of these chemicals is due to consolidated evidences underlining their role in the pathogenesis of several diseases such as cancer, obesity (Yang et al, 2015), diabetes (Chevalier and Fenichel, 2015) and reproductive pathologies (Kumar and Holt, 2015). EDCs exposure is particularly dangerous during childhood.…”

Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Section: Synthetic Xenoestrogens: Endocrine Disrupting Chemicals (mentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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“…Sperm from dead birds, could, however, be a useful resource when trying to set up germplasm banks. It might also provide useful information regarding the physiological reproductive status of the donor, and could even be used for examining the impact of environmental pollutants on reproductive function (Kumar and Holt ).…”

Section: Introductionmentioning

confidence: 99%

Influence of Post‐Mortem Sperm Recovery Method and Extender on Unstored and Refrigerated Rooster Sperm Variables

Villaverde‐Morcillo¹,

Esteso²,

Castaño³

et al. 2015

Reprod Domestic Animals

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Many post-mortem sperm collection techniques have been described for mammalian species, but their use in birds is scarce. This paper compares the efficacy of two post-mortem sperm retrieval techniques - the flushing and float-out methods - in the collection of rooster sperm, in conjunction with the use of two extenders, i.e., L&R-84 medium and Lake 7.1 medium. To determine whether the protective effects of these extenders against refrigeration are different for post-mortem and ejaculated sperm, pooled ejaculated samples (procured via the massage technique) were also diluted in the above extenders. Post-mortem and ejaculated sperm variables were assessed immediately at room temperature (0 h), and after refrigeration at 5°C for 24 and 48 h. The flushing method retrieved more sperm than the float-out method (596.5 ± 75.4 million sperm vs 341.0 ± 87.6 million sperm; p < 0.05); indeed, the number retrieved by the former method was similar to that obtained by massage-induced ejaculation (630.3 ± 78.2 million sperm). For sperm collected by all methods, the L&R-84 medium provided an advantage in terms of sperm motility variables at 0 h. In the refrigerated sperm samples, however, the Lake 7.1 medium was associated with higher percentages of viable sperm, and had a greater protective effect (p < 0.05) with respect to most motility variables. In conclusion, the flushing method is recommended for collecting sperm from dead birds. If this sperm needs to be refrigerated at 5°C until analysis, Lake 7.1 medium is recommended as an extender.

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“…Other known EDCs have teratogenic effects in marine invertebrate species used as sentinel species in marine biomonitoring programs, such as sea urchins, mussels, and ascidians (Dumollard et al, ; Gallo & Tosti, ; Kumar & Holt, ; Tosti & Gallo, ). However, it cannot be inferred from these studies whether the teratogenicity of the tested EDCs is caused by a mechanism akin to endocrine disruption, as none of the criteria used for establishing endocrine disruption (altered NR activity, altered hormone synthesis/degradation) have been tested.…”

Section: Edcs Are Toxic To Marine Embryosmentioning

confidence: 99%

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

Gomes

Gazo

Besnardeau

et al. 2019

Molecular Reproduction Devel

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Endocrine Disrupting Chemicals (EDCs) are molecules able to interfere with the vertebrate hormonal system in different ways, a major one being the modification of the activity of nuclear receptors (NRs). Several NRs are expressed in the vertebrate brain during embryonic development and these NRs are suspected to be responsible for the neurodevelopmental defects induced by exposure to EDCs in fishes or amphibians and to participate in several neurodevelopmental disorders observed in humans. Known EDCs exert toxicity not only on vertebrate forms of marine life but also on marine invertebrates. However, because hormonal systems of invertebrates are poorly understood, it is not clear whether the teratogenic effects of known EDCs are because of endocrine disruption. The most conserved actors of endocrine systems are the NRs which are present in all metazoan genomes but their functions in invertebrate organisms are still insufficiently characterized. EDCs like bisphenol A have recently been shown to affect neurodevelopment in marine invertebrate chordates called ascidians. Because such phenotypes can be mediated by NRs expressed in the ascidian embryo, we review all the information available about NRs expression during ascidian embryogenesis and discuss their possible involvement in the neurodevelopmental phenotypes induced by EDCs. K E Y W O R D S endocrine-disrupting chemicals, marine invertebrate, mode-of-action, neurodevelopment, nuclear receptors

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Impacts of Endocrine Disrupting Chemicals on Reproduction in Wildlife

Cited by 13 publications

References 91 publications

Risks and benefits related to alimentary exposure to xenoestrogens

Risks and benefits related to alimentary exposure to xenoestrogens

Influence of Post‐Mortem Sperm Recovery Method and Extender on Unstored and Refrigerated Rooster Sperm Variables

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

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