Impacts of chemical stress, season, and climate change on the flounder population of the highly anthropised Seine estuary (France)

Laurent, Jennifer; Lavergne, Édouard; Couteau, Jérôme; Floch, Stéphane Le; Ouddane, Baghdad; Cachot, Jérôme; Davail, Blandine; Clérandeau, Christelle; Devin, Simon; Fisson, Cédric; Devaux, Alain; Amara, Rachid; Diop, Mamadou; Pichereau, Vianney; Laroche, Jean

doi:10.1007/s11356-022-20000-y

Cited by 5 publications

(1 citation statement)

References 67 publications

(99 reference statements)

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“…Hematological parameters, like serum transaminases, provide general insights of the hepatic tissue health (Wang et al 2022 ; Fathy et al 2019 ; Cai et al 2018 ; Kroon et al 2017 ). Endocrine parameters, notably vitellogenin, genotoxic parameters such as DNA adducts, secondary DNA modifications, and irreversible genotoxic events, apoptosis, and micronuclei are also valuable biomarkers (Haque et al 2022 ; Laurent et al 2022 ; Simó-Mirabet et al 2018 ; Casatta et al 2017 ). Liver structural alterations, as histopathological biomarkers of effect, are important non-specific indicators of fish health as they bear the effects of exposure to various pollutants (Hinton et al 1992 ).…”

Section: Fish Liver Oxidative Stress and Biomarkersmentioning

confidence: 99%

Fish liver damage related to the wastewater treatment plant effluents

Popović

Čižmek

Babić

et al. 2023

Environ Sci Pollut Res

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Wastewater treatment plants (WWTPs) continuously release a complex mixture of municipal, hospital, industrial, and runoff chemicals into the aquatic environment. These contaminants are both legacy contaminants and emerging-concern contaminants, affecting all tissues in a fish body, particularly the liver. The fish liver is the principal detoxifying organ and effects of consistent pollutant exposure can be evident on its cellular and tissue level. The objective of this paper is thus to provide an in-depth analysis of the WWTP contaminants’ impact on the fish liver structure, physiology, and metabolism. The paper also gives an overview of the fish liver biotransformation enzymes, antioxidant enzymes, and non-enzymatic antioxidants, their role in metabolizing xenobiotic compounds and coping with oxidative damage. Emphasis has been placed on highlighting the vulnerability of fish to xenobiotic compounds, and on biomonitoring of exposed fish, generally involving observation of biomarkers in caged or native fish. Furthermore, the paper systematically assesses the most common contaminants with the potential to affect fish liver tissue. Graphical Abstract

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