Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development

Penhale, Samantha H.; Picci, Giorgia; Ott, Lauren R.; Taylor, Brittany K.; Frenzel, Michaela R.; Eastman, Jacob A.; Wang, Yuping; Calhoun, Vince D.; Stephen, Julia M.; Wilson, Tony W.

doi:10.1016/j.dcn.2022.101153

Cited by 9 publications

(5 citation statements)

References 78 publications

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“…Our cross-sectional design allowed us to look at a broad age range, but we were unable to examine person-specific trajectories from this design. Second, many of our participants were in the childhood to adolescence age range, and therefore the effects of pubertal hormones, irrespective of age, could be impactful in this sample ( 46 ). Finally, the present study was limited to examining differences in absolute and relative power as well as examining age- and sex-related associations with spontaneous neural dynamics.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous cortical dynamics from the first years to the golden years

Rempe

Ott

Picci

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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In the largest and most expansive lifespan magnetoencephalography (MEG) study to date (n = 434, 6 to 84 y), we provide critical data on the normative trajectory of resting-state spontaneous activity and its temporal dynamics. We perform cutting-edge analyses to examine age and sex effects on whole-brain, spatially-resolved relative and absolute power maps, and find significant age effects in all spectral bands in both types of maps. Specifically, lower frequencies showed a negative correlation with age, while higher frequencies positively correlated with age. These correlations were further probed with hierarchical regressions, which revealed significant nonlinear trajectories in key brain regions. Sex effects were found in absolute but not relative power maps, highlighting key differences between outcome indices that are generally used interchangeably. Our rigorous and innovative approach provides multispectral maps indicating the unique trajectory of spontaneous neural activity across the lifespan, and illuminates key methodological considerations with the widely used relative/absolute power maps of spontaneous cortical dynamics.

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Section: Discussionmentioning

confidence: 99%

Spontaneous cortical dynamics from the first years to the golden years

Rempe

Ott

Picci

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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“…Teasing apart these respective effects helps to shed light on different developmental processes that are happening in concert. Such findings likely indicate that maturational processes less related to testosterone are also ongoing and contributing to network refinement, including processes related to DHEA and other hormones (Penhale et al, 2022; Picci, Casagrande, et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth

Killanin,

Ward,

Embury

et al. 2024

Human Brain Mapping

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Testosterone levels sharply rise during the transition from childhood to adolescence and these changes are known to be associated with changes in human brain structure. During this same developmental window, there are also robust changes in the neural oscillatory dynamics serving verbal working memory processing. Surprisingly, whereas many studies have investigated the effects of chronological age on the neural oscillations supporting verbal working memory, none have probed the impact of endogenous testosterone levels during this developmental period. Using a sample of 89 youth aged 6–14 years‐old, we collected salivary testosterone samples and recorded magnetoencephalography during a modified Sternberg verbal working memory task. Significant oscillatory responses were identified and imaged using a beamforming approach and the resulting maps were subjected to whole‐brain ANCOVAs examining the effects of testosterone and sex, controlling for age, during verbal working memory encoding and maintenance. Our primary results indicated robust testosterone‐related effects in theta (4–7 Hz) and alpha (8–14 Hz) oscillatory activity, controlling for age. During encoding, females exhibited weaker theta oscillations than males in right cerebellar cortices and stronger alpha oscillations in left temporal cortices. During maintenance, youth with greater testosterone exhibited weaker alpha oscillations in right parahippocampal and cerebellar cortices, as well as regions across the left‐lateralized language network. These results extend the existing literature on the development of verbal working memory processing by showing region and sex‐specific effects of testosterone, and are the first results to link endogenous testosterone levels to the neural oscillatory activity serving verbal working memory, above and beyond the effects of chronological age.

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“…Future studies should try to improve in these areas, as effects likely differ based on the duration of consumption and developmental effects in theta and gamma oscillations. Such developmental effects in neural oscillations and connectivity are known to be ubiquitous (Fung et al, 2021;Fung et al, 2022aFung et al, , 2022bKillanin et al, 2023;Ott et al, 2021;Penhale et al, 2022;Rempe et al, 2023;Son et al, 2023;Taylor et al, 2021Taylor et al, , 2022. Finally, future studies should integrate data on sleep quality and tobacco use to ensure any cannabis-related differences are not due to these factors.…”

Section: Discussionmentioning

confidence: 99%

Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing

Castelblanco,

Springer,

Schantell

et al. 2024

J Psychopharmacol

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Background: Cannabis is the most widely used psychoactive drug in the United States. While multiple studies have associated acute cannabis consumption with alterations in cognitive function (e.g., visual and spatial attention), far less is known regarding the effects of chronic consumption on the neural dynamics supporting these cognitive functions. Methods: We used magnetoencephalography (MEG) and an established visuospatial processing task to elicit multi-spectral neuronal responses in 44 regular cannabis users and 53 demographically matched non-user controls. To examine the effects of chronic cannabis use on the oscillatory dynamics underlying visuospatial processing, neural responses were imaged using a time-frequency resolved beamformer and compared across groups. Results: Neuronal oscillations serving visuospatial processing were identified in the theta (4–8 Hz), alpha (8–14 Hz), and gamma range (56–76 Hz), and these were imaged and examined for group differences. Our key results indicated that users exhibited weaker theta oscillations in occipital and cerebellar regions and weaker gamma responses in the left temporal cortices compared to non-users. Lastly, alpha oscillations did not differ, but alpha connectivity among higher-order attention areas was weaker in cannabis users relative to non-users and correlated with performance. Conclusions: Overall, these results suggest that chronic cannabis users have alterations in the oscillatory dynamics and neural connectivity serving visuospatial attention. Such alterations were observed across multiple cortical areas critical for higher-order processing and may reflect compensatory activity and/or the initial emergence of aberrant dynamics. Future work is needed to fully understand the implications of altered multispectral oscillations and neural connectivity in cannabis users.

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Impacts of adrenarcheal DHEA levels on spontaneous cortical activity during development

Cited by 9 publications

References 78 publications

Spontaneous cortical dynamics from the first years to the golden years

Spontaneous cortical dynamics from the first years to the golden years

Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth

Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing

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