“…We included 7 controlled studies, which enrolled a total of 12,362 participants 14 , 15 , 17 , 18 , [20] , [21] , [22] . Included studies were conducted in the last decade in the USA (n=3 studies 15 , 18 , 20 ), Chile (n=2 studies 17 , 21 ), France (n=1 study 22 ), and Israel (n=1 study 14 ). Three of the studies were set in adult ICUs 15 , 18 , 20 , one in paediatric ICU 21 , one in aged care facility 22 , one in acute care ward 17 , and one in long-term care for ventilator dependent patients 14 .…”