Impacto da hepatite C na mortalidade de pacientes em hemodiálise

Abstract

Objective: Cardiovascular diseases are the most important causes of mortality in patients with end-stage renal disease. However, viral infections (hepatitis B and C) have acquired great importance for patients undergoing hemodialysis, because they affect patients' survival and increase morbidity and mortality. This study aimed at assessing the influence of hepatitis C on the mortality of patients undergoing hemodialysis. Methods: This is a non-concurrent cohort study during a period of ten years. Results: Each cohort comprised 74 patients. Hepatitis C did not increase the risk of death, and the survival of infected patients was better than that of patients without hepatitis C. The one-year and five-year survivals of non-infected patients were 93.9% and 52.3%, respectively, while those of noninfected patients were 95.5% and 73.1%, respectively (Cox-Mantel log-rank, p = 0.02). Conclusion: No increase in mortality risk was observed. Hepatitis C did not correlate with an increase in mortality in patients with end-stage renal disease undergoing hemodialysis.

Hemodiyaliz Hastalarında HBV, HCV ve HIV Seroprevalansı ve Hepatit B Aşılaması ile Oluşan Antikor Cevabının Değerlendirilmesi

“…HD hastaları arasında dünyada yapılan çalışmalar incelendiğinde, anti-HCV pozitifliğinde zaman içinde düşüş gözlendiği gibi bazı ülkelerde ise artışlar saptanmıştır. Yani problem hala devam etmektedir (2,(16)(17)(18). Diyaliz hastalarında HCV enfeksiyonunun ayrı bir önemi vardır, çünkü nozokomiyal geçiş nedeniyle normal topluma göre görülme sıklığı çok daha yüksektir (19,20).…”