Impaction bone grafting with freeze-dried irradiated bone. Part I. Femoral implant stabilityCadaver experiments in a hip simulator

Bavadekar, Ashit; Godts, Bernard; Tomme, John Van; Delloye, Christian; Banse, Xavier

doi:10.1080/00016470310017938

Cited by 27 publications

(18 citation statements)

References 11 publications

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“…Mechanical benefit of the low temperature during irradiation is obvious when Cell Tissue Bank (2011) 12:281-288 283 compared to the freeze-dried irradiated at room temperature series. On the other hand, the interest of freeze-dried irradiated bone brittleness for impaction bone grafting has been demonstrated (Cornu et al 2003a(Cornu et al , b, 2004a. Performing freeze-drying after irradiation allowed strain preservation but work to failure was decreased due to the stiffness and stress drops.…”

Section: Discussionmentioning

confidence: 98%

Synergetic effect of freeze-drying and gamma irradiation on the mechanical properties of human cancellous bone

et al. 2010

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Freeze-drying and irradiation are common process used by tissue banks to preserve and sterilize bone allografts. Freeze dried irradiated bone is known to be more brittle. Whether bone brittleness is due to irradiation alone, temperature during irradiation or to a synergetic effect of the freeze-drying-irradiation process was not yet assessed. Using a left-right femoral head symmetry model, 822 compression tests were performed to assess the influence of sequences of a 25 kGy irradiation with and without freeze-drying compared to the unprocessed counterpart. Irradiation of frozen bone did not cause any significant reduction in ultimate strength, stiffness and work to failure. The addition of the freeze-drying process before or after irradiation resulted in a mean drop of 35 and 31% in ultimate strength, 14 and 37% in stiffness and 46 and 37% in work to failure. Unlike irradiation at room temperature, irradiation under dry ice of solvent-detergent treated bone seemed to have no detrimental effect on mechanical properties of cancellous bone. Freeze-drying bone without irradiation had no influence on mechanical parameters, but the addition of irradiation to the freeze-drying step or the reverse sequence showed a detrimental effect and supports the idea of a negative synergetic effect of both procedures. These findings may have important implications for bone banking.

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Section: Discussionmentioning

confidence: 98%

Synergetic effect of freeze-drying and gamma irradiation on the mechanical properties of human cancellous bone

et al. 2010

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“…In our previous studies, we have shown that femoral impaction reconstructions performed with freeze-dried irradiated bone are more stable than those performed with fresh-frozen bone in an invitro cyclic loading of cadaver femurs (Cornu et al 2003a) and that freeze-dried irradiated bone simply became impacted much faster than the fresh-frozen controls in the same experimental model as those described in this paper (Cornu et al 2003b). The first step of freeze-dried bone process is the removal of bone marrow and cell remains by solvent-detergent (Delloye et al 1987).…”

Section: Discussionmentioning

confidence: 98%

Freeze-dried irradiated bone brittleness improves compactness in an impaction bone grafting model

Libouton

Naets

Godts

et al. 2004

Acta Orthopaedica Scandinavica

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Background Defatted bone chips with or without freeze-drying and irradiation have mechanical advantages as compared to fresh-frozen controls in in vitro models of impaction. These improved results have been ascribed to replacement of viscous bone marrow by saline and embrittlement of the freeze-dried bone by irradiation.Material and methods To determine which of these hypotheses is correct, we compared the development of stiffness and compactness of morselized bone graft that had been: 1) fat-reduced with saline, and 2) fresh-frozen, solvent-detergent defatted, 3) freeze-dried irradiated and 4) not irradiated. We used 12 osteoarthrotic femoral heads to prepare these four batches of morselized bone, and impacted 18 samples from each batch in a cylinder. The frozen bone grafts were tested after thawing at room temperature for 2 hours and the freeze-dried grafts were tested after 30 minutes of rehydration. We monitored the development of compactness and stiffness of the material during impaction.Results The stiffness of the freeze-dried irradiated bone was greater than that of the other three series after 10, 50 and 150 impactions. The freeze-dried bone chips that were not irradiated and the chips defatted with saline alone were less stiff than the fresh-frozen control after 150 impactions.Interpretation The brittleness of freeze-dried irradiated bone, caused by loss of the capacity to absorb energy in a plastic way, increases the compactness and stiffness of the morselized grafts. Washing bone with saline alone or treating bone with solvent-detergent but no irradiation had no similar mechanical advantage and the bone did not impact better than fresh-frozen undefatted bone in our model.

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“…Other variables such as type of stem or socket implanted, graft size and treatment, and (not least) impaction technique may have more or less of an influence on the results (Höstner et al 2001, van Doorn et al 2002, Bolder et al 2003, Cornu et al 2003a,b, Jeffery et al 2003. In this study we tried to reduce the effect of these confounders by use of a control group.…”

Section: Discussionmentioning

confidence: 99%

Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases

et al. 2006

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Impaction bone grafting with freeze-dried irradiated bone. Part I. Femoral implant stabilityCadaver experiments in a hip simulator

Cited by 27 publications

References 11 publications

Synergetic effect of freeze-drying and gamma irradiation on the mechanical properties of human cancellous bone

Synergetic effect of freeze-drying and gamma irradiation on the mechanical properties of human cancellous bone

Freeze-dried irradiated bone brittleness improves compactness in an impaction bone grafting model

Mixing bone graft with OP-1 does not improve cup or stem fixation in revision surgery of the hip: 5-year follow-up of 10 acetabular and 11 femoral study cases and 40 control cases

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