Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy
Shicheng Jiang,
Bei Liu,
Kaiwen Lin
et al.
Abstract:Numerous epilepsy‐related genes have been identified in recent decades by unbiased genome‐wide screens. However, the available druggable targets for temporal lobe epilepsy (TLE) remain limited. Furthermore, a substantial pool of candidate genes potentially applicable to TLE therapy awaits further validation. In this study, we reveal the significant role of KCNQ2 and KCNQ3, two M‐type potassium channel genes, in the onset of seizures in TLE. Our investigation began with a quantitative analysis of two publicly a… Show more
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