Impact on respiratory tract infections of heptavalent pneumococcal conjugate vaccine administered at 3, 5 and 11 months of age

Esposito, Susanna; Lizioli, A; Lastrico, Annalisa; Begliatti, Enrica; Rognoni, Alessandro; Tagliabue, Claudia; Cesati, Laura; Carreri, Vittorio; Principi, Nicola

doi:10.1186/1465-9921-8-12

Cited by 48 publications

(36 citation statements)

References 44 publications

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“…In some countries, the introduction of this vaccine was followed by declines not only in pneumonia cases, but also in AOM and bronchitis [35,36]. In contrast, an increase in invasive pneumonia was reported in Spain after the introduction of the vaccine [37].…”

Section: Discussionmentioning

confidence: 89%

Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005–2009

Angoulvant

Skurnik

Bellanger

et al. 2011

Eur J Clin Microbiol Infect Dis

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Acute respiratory tract infections (ARTIs) are the main reason for antibiotic prescription in children. In 2005, the French Drug Agency published guidelines to minimise inappropriate use of antibiotics for ARTI. The purpose of this study was to assess the impact of implementing these guidelines in a paediatric emergency department. We retrospectively analysed data collected prospectively in a French paediatric emergency department from November 2005 (date of guideline implementation) to October 2009. For each child diagnosed with ARTI, we collected age, diagnosis, and prescribed antibiotics. We computed antibiotic prescription rates in the study population. During the study period, 53,055 children were diagnosed with ARTI and 59% of the 22,198 antibiotic prescriptions given at discharge were related to ARTI. The proportion of ARTI patients given antibiotic prescriptions fell from 32.1% during the first year to 21% in year 4 (p<10(-4), Cochran-Armitage test). Amoxicillin-clavulanic acid and amoxicillin accounted for 50% and 34% of antibiotic prescriptions for ARTI, respectively. French antibiotic guidelines led to significant decreases in antibiotic prescription for ARTI in our paediatric emergency department.

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Section: Discussionmentioning

confidence: 89%

Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005–2009

Angoulvant

Skurnik

Bellanger

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…A population-based study in Israel demonstrated the effectiveness of PCVs was 40.7%, for the control of alveolar pneumonias [13]. However two Italian studies that evaluated the impact of 2 + 1 schedule found significant reductions for pneumonia endpoints [14] [15].…”

Section: Discussionmentioning

confidence: 99%

Effect of 7 and 13-Valent Pneumococcal Conjugate Vaccines Different Number of Doses for Pneumonia Control in 2008 and 2010 Birth Cohort Children

Hortal¹,

Meny²,

Estevan³

et al. 2015

WJV

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“…This effectiveness has been demonstrated both for a standard vaccination schedule of three doses in the first 6 months of life, followed by a toddler dose at 12 to 15 months of age (5,8,14,32,38,45), and for a simplified schedule with a two-dose primary series and a toddler dose at 11 to 12 months (9,10,12,19,41). Besides the direct benefits for vaccinated infants and children, the administration of PCV7 has a substantial indirect effect in reducing the incidence of pneumococcal disease in unvaccinated adults, especially in those 65 years of age and older (4,13,24).…”

mentioning

confidence: 99%

Safety and Immunogenicity of a 13-Valent Pneumococcal Conjugate Vaccine Compared to Those of a 7-Valent Pneumococcal Conjugate Vaccine Given as a Three-Dose Series with Routine Vaccines in Healthy Infants and Toddlers

Esposito

Tansey

Thompson

et al. 2010

Clin Vaccine Immunol

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138

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A 13-valent pneumococcal conjugate vaccine (PCV13) has been developed to improve protection against pneumococcal disease beyond that possible with the licensed 7-valent vaccine (PCV7). This study compared the safety and immunogenicity of PCV13 with those of PCV7 when given as part of the pediatric vaccination schedule recommended in Italy. A total of 606 subjects were randomly assigned to receive either PCV13 or PCV7 at 3, 5, and 11 months of age; all subjects concomitantly received diphtheria-tetanus-acellular pertussishepatitis B-inactivated polio-Haemophilus influenzae type B (DTaP-HBV-IPV/Hib) vaccine. Vaccine reactions were monitored. Antibody responses to DTaP-HBV-IPV/Hib antigens, serotype-specific anticapsular polysaccharide IgG responses, and antipneumococcal opsonophagocytic assay (OPA) activity were measured 1 month after the two-dose primary series and 1 month after the toddler dose. Overall, the safety profile of PCV13 was similar to that of PCV7. The response to DTaP-HBV-IPV/Hib antigens was substantially the same with both PCV13 and PCV7. PCV13 elicited antipneumococcal capsular IgG antibodies to all 13 vaccine serotypes, with notable increases in concentrations seen after the toddler dose. Despite a lower immunogenicity for serotypes 6B and 23F after the primary series of PCV13, responses to the seven common serotypes were comparable between the PCV13 and PCV7 groups when measured after the toddler dose. PCV13 also elicited substantial levels of OPA activity against all 13 serotypes following both the infant series and the toddler dose. In conclusion, PCV13 appeared comparable to PCV7 in safety profile and immunogenicity for common serotypes, demonstrated functional OPA responses for all 13 serotypes, and did not interfere with immune responses to concomitantly administered DTaP-HBV-IPV/Hib vaccine.

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Impact on respiratory tract infections of heptavalent pneumococcal conjugate vaccine administered at 3, 5 and 11 months of age

Cited by 48 publications

References 44 publications

Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005–2009

Impact of implementing French antibiotic guidelines for acute respiratory-tract infections in a paediatric emergency department, 2005–2009

Effect of 7 and 13-Valent Pneumococcal Conjugate Vaccines Different Number of Doses for Pneumonia Control in 2008 and 2010 Birth Cohort Children

Safety and Immunogenicity of a 13-Valent Pneumococcal Conjugate Vaccine Compared to Those of a 7-Valent Pneumococcal Conjugate Vaccine Given as a Three-Dose Series with Routine Vaccines in Healthy Infants and Toddlers

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