Impact on Drug Development and Drug Product Processing

Page, Susanne; Szepes, Anikó

doi:10.1002/9783527823048.ch6

Cited by 1 publication

(1 citation statement)

References 143 publications

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“…Due to the various possible limitations with the GI system, hydrophilic macromolecular medicines, proteins primarily polysaccharides, therapeutic peptides, and DNA-based therapies, have low oral bioavailability. A range of tactics has been used to address this issue, including structural drug changes, addition of auxiliary agents, and the production of SEDDS nanocarriers, which are used in various studies as a prominent term for both self-nano- and self-micro emulsifying drug delivery systems (SNEDDS/SMEDDS) and emerge to be a successful method for oral medicines (Page & Szepes, 2021 ). The preparation of SEDDS on an industrial level is economical and simpler than other nanocarriers, including liposomes, micelles, polymer-based nanoparticles, carbon nanotubes, or niosomes, because it is almost like the solution preparation (Mahmood & Bernkop-Schnürch, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Salawi

2022

Drug Delivery

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Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to produce microemulsions or fine oil-in-water (o/w) emulsions after moderate stirring and dilution by water phase along the GI tract might be a promising technique for lipophilic agents with dissolution rate-limited absorption. This review provides an outline of SEDDS's numerous advances and biopharmaceutical elements, types, manufacturing, characterization, limitations, and future prospects. The evaluation of SEDDS and its applications are also discussed, focusing on the advances of SEDDS's solid self-emulsifying delivery mechanism and dosage form. By integrating suitable polymer into the formulation, SEDDS may be studied for the creation of a formulation with sustained drug release. This technology's improvement might lead to a new application in the field of medicine delivery. SEDDS has been demonstrated to be quite efficient in increasing oral bioavailability of lipophilic products. SEDDS is one of the promising methods for controlling the characteristics of medications that are not great choices for oral delivery. It is also worth mentioning that SEDDS may be made in variety of solid dosage forms that are acceptable for both oral and parenteral administration.

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Section: Introductionmentioning

confidence: 99%

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Salawi

2022

Drug Delivery

View full text Add to dashboard Cite

show abstract

Impact on Drug Development and Drug Product Processing

Cited by 1 publication

References 143 publications

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Self-emulsifying drug delivery systems: a novel approach to deliver drugs

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