Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV

Napier, T. Celeste

doi:10.1038/npp.2016.222

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV exposure may also perpetuate addiction to stimulants [155]. Studies of HIV suggest that neuropathologies and substance abuse disorders often have a complex relationship that cannot be classified in one direction [156][157][158]; HIV and substance use together frequently result in the exacerbation of CNS disorders [159]. EVs are likely a key communication factor causing this exacerbation and interrelationship between HIV and substance abuse [160], however further research needs to be performed.…”

Section: Evs Substance Abuse and Hivmentioning

confidence: 99%

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

Odegaard

Chand

Wheeler

et al. 2020

IJMS

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.

show abstract