Impact on Blood Tests of Lower Limb Joint Replacement for the Treatment of Osteoarthritis

Romero, Eleuterio A. Sánchez; Battaglino, Andrea; Campanella, William; Turroni, Silvia; Bishop, Mark D.; Villafañe, Jorge Hugo

doi:10.1097/tgr.0000000000000337

Cited by 14 publications

(15 citation statements)

References 10 publications

(23 reference statements)

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“…Thus, in the last decades, scientists have focused their attention on the identification of pain biomarkers in order to obviate a possible misdiagnosis, delayed clinical results and useless therapies [ 7 , 26 ]. Considering pain as the main symptom of their pathologies, FM and OA subjects, as other chronic pain patients, need urgent answers about the classification of their pain in order to undertake the best-tailored therapy [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…At the end, the utilization of a specific diagnostic biomarker could lead to an accurate recognition of the pain intensity, facilitating the prescription of the most suitable drug for the best patient management [ 27 , 31 ]. FM patients, for example, are usually overloaded by medical visits and pharmacological treatments because of psychiatric and psychological problems and/or biological and social environmental characteristics associated with their pathology [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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An Observational Study on Chronic Pain Biomarkers in Fibromyalgia and Osteoarthritis Patients: Which Role for Mu Opioid Receptor’s Expression on NK Cells?

et al. 2023

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The evaluation of chronic pain is challenging because of the lack of specific biomarkers. We identified the Mu opioid receptor-positive (Mu+) B cell percentage of expression, named Mu-Lympho-Marker (MLM), as a candidate marker for chronic pain in fibromyalgia (FM) and osteoarthritis (OA) patients. Here, we investigate the role of MLM on natural killer (NK) cells in the same patients. Twenty-nine FM and twelve OA patients were analyzed, and twenty-three pain-free subjects were considered as the control group. Blood samples were collected to perform immunophenotyping and Western blot analysis. Biological and clinical data were statistically analyzed. The final results showed that the percentage of NK cells expressing Mu was statistically lower in FM and OA patients than in pain-free subjects, as already demonstrated for B cells. A Western blot analysis was performed in order to detect NK cells’ functional status. Moreover, the correlation analysis of MLM expression with pharmacological therapy did not show any significant results. In conclusion, here, we confirm the role of MLM as a suitable marker for chronic pain and underline NK cells as a new possible immune cell type involved in the “Mu opioid receptor reserve theory”.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An Observational Study on Chronic Pain Biomarkers in Fibromyalgia and Osteoarthritis Patients: Which Role for Mu Opioid Receptor’s Expression on NK Cells?

et al. 2023

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“…The debate on whether mechanical and neutral tibial alignment is associated with superior durability and survivorship following TKA continues to garner interest as alternative alignment techniques show functional advantages [ 21 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. One recent long-term follow-up study (>10 years) supported the safety of alignment outside of the mechanical range (0 ± 3°); however, the tibia component varus was not specifically assessed [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Minimum 2-Year Radiographic and Clinical Outcomes of Unrestricted Kinematic Alignment Total Knee Arthroplasty in Patients with Excessive Varus of the Tibia Component

Ziv

Essa

Lamykin

et al. 2022

JPM

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Kinematic alignment (KA) total knee arthroplasty (TKA) has gained much attention in recent years. However, debate remains on whether restrictions should be made on the tibia cut. The purpose of this study was to assess the safety and functional outcomes of excessive varus cuts. A single-center, retrospective analysis of consecutive patients undergoing TKA between 2018 and 2020 who had a minimum 2-year follow-up was conducted. EOS™ imaging conducted before and after surgery was analyzed for overall alignment, as well as for tibia and femur component positioning on the coronal planes. Patients were interviewed and asked to fill several questionnaires, including the visual analog score, Oxford knee score, and knee injury and osteoarthritis outcome score. Overall, 243 patients (71.9%) had a coronal tibial plate angle under 5° (moderate) and 95 patients (28.1%) had an angle above 5° (excessive). There were no significant differences between the moderate and excessive groups in patient-reported outcomes, nor were there differences in the number of patients achieving the minimal clinical difference. There were no cases of catastrophic failure or loosening. Unrestricted KA and excessive varus of the tibial component appears to be safe and efficient in relieving pain and restoring function for a minimum of 2 years following surgery.

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“…IL-6 is a pro-inflammatory cytokine that induces the expression of a variety of proteins responsible for acute inflammation [ 28 , 49 ].…”

Section: Synovial Fluid Proteome In Osteoarthritismentioning

confidence: 99%

“…Yu et al [ 49 ], in a prospective study that recruited 139 patients affected by hip or knee PJI, showed synovial IL-6 has a higher diagnostic accuracy for PJI, compared with synovial fluid CRP. These authors recommend assessing synovial IL-6 in patients with an increased serum IL-6 [ 49 ].…”

Section: Synovial Fluid Proteome In Osteoarthritismentioning

confidence: 99%

The Usefulness of Synovial Fluid Proteome Analysis in Orthopaedics: Focus on Osteoarthritis and Periprosthetic Joint Infections

Bizzoca

Moretti

Gnoni

et al. 2022

JFMK

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Synovial fluid (SF) is a viscous and mucinous substance produced by the synovium, a specialized connective tissue that lines diarthrodial joints. SF represents a source of disease-related proteins that could be used as potential biomarkers in several articular diseases. Based on these findings the study of SF has been gaining increasing importance, in recent years. This review aims to summarize the usefulness of synovial fluid in orthopaedics research and clinical practice, mainly focusing on osteoarthritis (OA) and periprosthetic joint infections (PJIs). Proteomics of the SF has shown the up-regulation of several components of the classic complement pathway in OA samples, including C1, C2, C3, C4A, C4B, C5, and C4 C4BPA, thus depicting that complement is involved in the pathogenesis of OA. Moreover, proteomics has demonstrated that some pro-inflammatory cytokines, namely IL-6, IL-8, and IL-18, have a role in OA. Several SF proteins have been studied to improve the diagnosis of PJIs, including alpha-defensin (Alpha-D), leukocyte esterase (LE), c-reactive protein (CRP), interleukin-6 (IL-6), calprotectin and presepsin. The limits and potentials of these SF biomarkers will be discussed.

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Impact on Blood Tests of Lower Limb Joint Replacement for the Treatment of Osteoarthritis

Cited by 14 publications

References 10 publications

An Observational Study on Chronic Pain Biomarkers in Fibromyalgia and Osteoarthritis Patients: Which Role for Mu Opioid Receptor’s Expression on NK Cells?

An Observational Study on Chronic Pain Biomarkers in Fibromyalgia and Osteoarthritis Patients: Which Role for Mu Opioid Receptor’s Expression on NK Cells?

Minimum 2-Year Radiographic and Clinical Outcomes of Unrestricted Kinematic Alignment Total Knee Arthroplasty in Patients with Excessive Varus of the Tibia Component

The Usefulness of Synovial Fluid Proteome Analysis in Orthopaedics: Focus on Osteoarthritis and Periprosthetic Joint Infections

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