Impact of xenoestrogens on sex differentiation and reproduction in teleosts

Roy, Brototi; Basak, Reetuparna; Rai, Umesh

doi:10.1016/j.aaf.2022.02.001

Cited by 9 publications

(4 citation statements)

References 140 publications

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“…Therefore, disruption in the synthesis of reproductive hormones like T, E2 and 11-keto levels may be associated with skewed sex ratios (Andersen et al 2004), and absence of reproductive behaviour (Hallgren et al 2006). Such abnormalities may result in declining the population of fishes (Roy et al 2022;Ankley et al 2002). However, further 8 studies are needed to monitor the deleterious effects of mixture of the pesticides having the low degradation rate and continuously reported in the aquatic impoundments.…”

Section: Discussionmentioning

confidence: 99%

Herbicides mixture with potent endocrine-disrupting properties in goldfish: As an early warning at environmentally relevant concentration.

Fatima

Rasool

2022

Preprint

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For a meaningful interpretation of toxic effects in fish, knowledge of sub-lethal events is essential and for this reason, we have conducted a series of studies with a relevant environmental concentration of a mixture of herbicides; Atrazine, simazine, diuron and isoproturon (ASDI) pollutants and using immune (Fatima et al. 2007) and endocrinological changes as principal endpoints under controlled laboratory conditions. Goldfish (Carassius auratus) were exposed to a cumulative concentration of 50µg/l of ASDI mixture for 12 weeks which was reported above the permissible level in the drinking water of Belgium (EAEW report, 1998) and nearby aquatic environments, confirming some of these herbicides still persistence despite restriction policies (Pesce et al. 2010;Agbohessi et al. 2014).Control and exposed fish were sampled at week-4, 8, and 12. We investigated the endocrine modulatory effect of ASDI which shows a low degradation rate in water. Thus, at the realistic level of ASDI concentration, significantly increased levels of cortisol and aromatase after 4-weeks were recorded. Reduction in aromatase activity at 8 and 12 weeks is followed by estradiol (E2) showing a positive correlation between them. Hence, 11-Keto reduced significantly at 4-8 weeks and enhanced at 12 weeks. Remarkable reduction in E2 and 11-Keto may be correlated with the reduced egg production in stressed fish by these herbicides. However, no remarkable change in testosterone is observed at 4 and 12 weeks as compared to the control. ASDI mixture treatment induced remarkable induction in vitellogenin (Vtg) biomarker protein in male stressed fish. Furthermore, it may confer that modulation in the pathway of the reproductive cycle may alter the gamete quality, quantity and consequently may disrupt spawning and mating behaviour in fishes even at a realistic level of pollutant in the environment.

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Section: Discussionmentioning

confidence: 99%

Herbicides mixture with potent endocrine-disrupting properties in goldfish: As an early warning at environmentally relevant concentration.

Fatima

Rasool

2022

Preprint

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“…It is well established that xeno‐estrogens and xeno‐androgens modulate the reproductive system and metabolism of fish (Carnevalli et al ., 2017; Roy et al ., 2022; Werner et al ., 2010) (Figure 1). Recently, steroidogenic EDCs have been shown to modulate the innate and adaptive immunity in fish and their defence mechanism against pathogens (Abo‐Al‐Ela et al ., 2017; Bado‐Nilles et al ., 2014; Cabas et al ., 2012; Chen et al ., 2017; Kernen et al ., 2022; Maciuszek et al ., 2020; Massart et al ., 2015; Rehberger et al ., 2020).…”

Section: Modulation Of Immune Responses By Steroidogenic Edcsmentioning

confidence: 99%

Crosstalk between reproductive and immune systems: the teleostean perspective

Chuphal

Sathoria

Rai

et al. 2022

Journal of Fish Biology

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The bidirectional interaction between the hypothalamic-pituitary-gonadal (HPG) axis and the immune system plays a crucial role in the adaptation of an organism to its environment, its survival and the continuance of a species. Nonetheless, very little is known about this interaction among teleost, the largest group of extant vertebrates.Fishes being seasonal breeders, their immune system is exposed to seasonally changing levels of HPG hormones. On the contrary, the presence and infiltration of leukocytes, the expression of pattern recognition receptors as well as cytokines in gonads suggest their key role in teleostean gametogenesis as in the case of mammals. Moreover, the modulation of gametogenesis and steroidogenesis by lipopolysaccharide implicates the pathological significance of inflammation on reproduction. Thus, it is important to engage in the understanding of the interaction between these two important physiological systems, not only from a phylogenetic perspective but also due to the importance of fish as an important economic resource. In view of this, the authors have reviewed the crosstalk between the reproductive and immune systems in teleosts and tried to explore the importance of this interaction in their survival and reproductive fitness.

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“…Their mode of action is to disrupt endocrine function and imposes a challenge to the sexual development of animals. It is of great concern for ecotoxicological researchers to avoid their hazardous and retrogressive effect due to their function as hormone mimic compounds [31]. As well researchers should focus on studies whether they act in an additive, synergistic, or antagonistic manner [22].…”

Section: Introductionmentioning

confidence: 99%

Herbicides Mixture with Potent Endocrine-Disrupting Properties In Goldfish: As An Early Warning At Environmentally Relevant Concentration

2023

EESRR

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For a meaningful interpretation of sub-lethal effect on fish, we have conducted a series of studies with a relevant environmental concentration of a mixture of herbicides; Atrazine, simazine, diuron and isoproturon (ASDI) to observe endocrine-disruption in goldfish under controlled laboratory conditions. Carassius auratus were exposed to 50µg/l of ASDI mixture for 12 weeks. Recorded mid-term assays shows, significant increased levels of cortisol and aromatase after 4-weeks. Reduction in aromatase activity at 8 and 12 weeks is followed by estradiol (E2) showing a positive correlation between them. Hence, 11-Keto reduced significantly at 4-8 weeks and enhanced at 12 weeks. Remarkable reduction in E2 and 11-Keto may be correlated with the reduced egg production in stressed fish by these herbicides. However, no remarkable change in testosterone is observed at 4 and 12 weeks as compared to the control. ASDI mixture treatment induced remarkable induction in vitellogenin (Vtg) biomarker protein in male stressed fish. Furthermore, it may confer that modulation in the pathway of the reproductive cycle may alter the gamete quality, quantity and consequently may disrupt spawning and mating behaviour in fishes even at a realistic level of pollutant in the environment.

show abstract

Impact of xenoestrogens on sex differentiation and reproduction in teleosts

Cited by 9 publications

References 140 publications

Herbicides mixture with potent endocrine-disrupting properties in goldfish: As an early warning at environmentally relevant concentration.

Herbicides mixture with potent endocrine-disrupting properties in goldfish: As an early warning at environmentally relevant concentration.

Crosstalk between reproductive and immune systems: the teleostean perspective

Herbicides Mixture with Potent Endocrine-Disrupting Properties In Goldfish: As An Early Warning At Environmentally Relevant Concentration

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