Impact of weight loss on the metabolic syndrome

Case, Christopher; Jones, Peter H.; Nelson, Kathleen W.; Smith, E O; Ballantyne, Christie M.

doi:10.1046/j.1463-1326.2002.00236.x

Cited by 173 publications

(107 citation statements)

References 23 publications

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“…17,18 Our results showed that changes in plasma adiponectin were inversely correlated with the changes in HOMA-IR, which was in agreement with previous findings. 19,20 It has been reported that ADIPOQ 276G4T genotypes had a strong association with IR and type 2 diabetes, which might be mediated through alterations in the expression levels of plasma adiponectin.…”

Section: Discussionsupporting

confidence: 93%

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

et al. 2006

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Objective: The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention. Subjects: In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of À300kcal/day. Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting glucose and insulin concentrations. We genotyped for three SNPs, 45T4G, 276G4T and À11377C4G. Results: At baseline, HOMA-IR was significantly higher in GG homozygotes than in carriers of the T allele at SNP276G4T of the adiponectin gene (Po0.05). With regard to SNP45T4G and SNP À11377C4G, we did not find any genotype related differences in baseline levels of HOMA-IR and adiponectin. In the 45/276 haplotype test, homozygous for the TG haplotype had significantly lower concentrations of plasma adiponectin (Po0.05). After the 12-week weight loss intervention, the significant decreases in HOMA-IR (Po0.001) and increases in adiponectin (Po0.01) were observed in GG homozygotes at SNP276, which were not shown in carriers of the T allele. Furthermore, there was a significant difference in the decreases in HOMA-IR between the GG homozygotes and carriers of the T allele at SNP276 (Po0.05). Regarding SNP45T4G and SNP À11377C4G, there was no association between SNP45T4G and SNP À11377C4G and decreases in HOMA-IR. In the 45/276 haplotype test, there was a significant difference in changes of adiponectin levels among those with different haplotype combinations (Po0.05). Conclusion: The SNP276G4T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects.

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Section: Discussionsupporting

confidence: 93%

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

et al. 2006

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“…This is higher compared to the E25% found in the general population, 17 but lower as the 68% found in a group of subjects enrolled in a structured weight loss program. 18 The exclusion of patients taking medication influencing coagulation, blood lipids or blood pressure probably lowered the percentage of patients diagnosed with the metabolic syndrome in our study.…”

Section: Discussionmentioning

confidence: 74%

Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome

et al. 2006

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Objective: To investigate whether leukocyte count, fibrinogen, von Willebrand factor (vWF) and plasminogen activator inhibitor-1 activity (PAI-1) are increased in subjects with the metabolic syndrome as defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) and the World Health Organisation (WHO). Design: Cross-sectional study. Subjects: A total of 520 overweight and obese subjects: 379 women and 141 men, visiting the weight management clinic of a University Hospital. Subjects and measurements: Waist circumference, triglycerides, HDL cholesterol, blood pressure and fasting glucose were determined, and the presence or absence of the metabolic syndrome according to the NCEP-ATPIII criteria was assessed. In 349 subjects, data on the waist-to-hip ratio (WHR) and albumin excretion rate were available and the WHO criteria were applied. Insulin resistance was defined using the HOMA-IR index. Results: Subjects with the metabolic syndrome according to the NCEP-ATPIII criteria had significantly higher levels of leukocyte count (Po0.001) and PAI-1 (Po0.001), while no significant differences were found for fibrinogen or vWF (P40.05). Using the WHO criteria, similar results were found except for vWF, where higher levels were found in subjects with the metabolic syndrome. When subjects were classified according to the number of components of the metabolic syndrome, levels of leukocyte count, vWF and PAI-1 activity were significantly different (Po0.05). In logistic regression analysis PAI-1, gender and leukocyte count were independent determinants of the metabolic syndrome (Po0.001). Conclusion: Evidence for being a true component of the metabolic syndrome is strong for PAI-1, less for leukocyte count and weak for vWF and fibrinogen.

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“…Obesity and physical activity are two important determinants of the metabolic syndrome (12)(13)(14)(15). Because the prevalence of obesity has continued to increase in the U.S. during the 1990s (16,17), we theorized that the prevalence of the metabolic syndrome among adults had increased as well.…”

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confidence: 99%

Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults

2004

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OBJECTIVE -The prevalence of the metabolic syndrome is high among U.S. adults. Our purpose was to determine whether the prevalence of this syndrome has changed since 1988 -1994. RESEARCH DESIGN AND METHODS-A total of 6,436 men and women aged Ն20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988III ( -1994 and 1,677 participants from NHANES 1999 -2000 were included in the analyses. We used the definition of the metabolic syndrome developed by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.RESULTS -The unadjusted prevalence of the metabolic syndrome was 23.1% in NHANES III and 26.7% in NHANES 1999 -2000 (P ϭ 0.043), and the age-adjusted prevalences were 24.1 and 27.0% (P ϭ 0.088), respectively. The age-adjusted prevalence increased by 23.5% among women (P ϭ 0.021) and 2.2% among men (P ϭ 0.831). Increases in high blood pressure, waist circumference, and hypertriglyceridemia accounted for much of the increase in the prevalence of the metabolic syndrome, particularly among women.CONCLUSIONS -The increased prevalence of the metabolic syndrome is likely to lead to future increases in diabetes and cardiovascular disease.

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Impact of weight loss on the metabolic syndrome

Abstract: The MS is prevalent in two-thirds of obese individuals enrolling in a structured weight loss programme. Moderate weight loss with a VLCD markedly improved all aspects of the MS.

Cited by 173 publications

References 23 publications

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss

Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome

Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults

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