Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: a randomised clinical trial

Bansal, Priyanka Gupta; Toteja, G S; Bhatia, Neena; Vikram, Naval K.; Siddhu, Anupa

doi:10.1038/ejcn.2015.215

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…[8] In the Yen Bai setting, it took 12 months of weekly supplementation for the population prevalence of anaemia to drop below 20% and up to 6 years (72 months) for the prevalence to be significantly below the 20% level. This slow rate of decline in anaemia levels has also been noted in other studies [22, 23] and suggests greater benefits if weekly or biweekly supplementation is given continuously, at least in the first year, and continued for several years.…”

Section: Discussionsupporting

confidence: 81%

Sustained effectiveness of weekly iron-folic acid supplementation and regular deworming over 6 years in women in rural Vietnam

et al. 2017

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BackgroundWeekly iron-folic acid (IFA) supplementation and regular deworming is effective for the prevention of iron deficiency and anaemia in women of child-bearing age. Between 2006 and 2013, a program of weekly IFA and biannual deworming was implemented in Yen Bai province, Vietnam. In this study we aimed to determine the effectiveness of the program in reducing anaemia and the prevalence of hookworm infection after 72 months (six years).MethodsThis prospective cohort study followed up a cohort of 389 women of child-bearing age from baseline until six years after the introduction of the weekly IFA (one tablet containing 200 mg ferrous sulphate, 0.4mg folic acid) and deworming (one 400mg tablet of albendazole given twice yearly) program (May 2006 to 2012). In each of the six surveys (baseline and five follow-up surveys) we measured haemoglobin and ferritin, and the burden of soil transmitted helminth (STH) infections, and in the 72 month survey we also administered a questionnaire to assess adherence and possible impediments to participating in the program.ResultsTwo hundred and fifty six (65.8%) of the original 389 women enrolled in the cohort attended the final 72 month survey. Haemoglobin levels were 122 g/L [95% C.I. 120, 124] at baseline and increased to 135g/L [95% C.I. 133, 138] after 72 months. The prevalence of anaemia was 37.8% [95% C.I. 31.0, 44.7] at baseline and reduced to 14.3% [95% C.I. 9.5, 19.1]. Hookworm infection prevalence, 75.9% [95% C.I. 68.1, 83.8] at baseline, reduced to 10.2% [95% C.I. 5.4, 15.0] with no moderate or heavy intensity infections. Seventy-two percent of participants reported still taking at least 75% of the weekly supplements, and 85.0% had taken the most recent deworming treatment.DiscussionAnaemia rates fell significantly during the six-year program, and STH infections were eliminated as a public health risk. Adherence was well maintained but long-term sustainability is challenging in the absence of ongoing external support.

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Section: Discussionsupporting

confidence: 81%

Sustained effectiveness of weekly iron-folic acid supplementation and regular deworming over 6 years in women in rural Vietnam

et al. 2017

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“…Iron and folic acid supplementation. Moderate-quality evidence, largely based on small-scale programmes in LMIC, suggests that weekly IFA supplementation (60 mg Fe/d with 400 µg folic acid/d) among adolescents leads to a significant reduction in anaemia among both girls and boys (17)(18)(19)(20)(21)(22)(23)(24)(25)(26) . In particular, recent evidence pooling data from twenty-three trials among adolescents in low-, middle-and high-income countries showed that IFA significantly reduced anaemia and improved serum Hb levels (18) .…”

Section: Micronutrient Supplementationmentioning

confidence: 99%

Potential interventions targeting adolescent nutrition in Indonesia: a literature review

Oddo¹,

Roshita²,

Rah³

2018

Public Health Nutr.

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ObjectiveThe present study aimed to take stock of nutrition interventions that warrant consideration as a minimum package of interventions in Indonesia to improve four key nutrition indicators for adolescents: stunting, thinness, overweight and anaemia.DesignWe conducted a review of the peer-reviewed literature published between 1995 and 2017 on nutrition-specific and nutrition-sensitive interventions that target adolescents in Indonesia. The search to identify studies was conducted in PubMed, Google Scholar and EMBASE, using key search terms. We also explored programmatic and policy documents from the grey literature as they related to adolescents and/or Indonesia. Our search yielded thirty-five peer-reviewed articles and programmatic documents.SettingIndonesia.SubjectsAdolescent girls and boys.ResultsThere is very limited evidence on the impact of interventions specifically among adolescents in Indonesia. Nevertheless, findings from our review suggest the minimum package of interventions in Indonesia could include the following nutrition-specifc interventions: (i) iron–folic acid supplements, paired with antihelminths delivered at scale via school-based platforms and through health centres; and (ii) diet counselling and nutrition education provided through school-based platforms, adolescent youth centres/peer education and technology-based platforms. The minimum package could also include the following nutrition-sensitive interventions: (i) improving access to reproductive health services; and (ii) increasing the coverage of interventions designed to increase school attendance.ConclusionsProgrammes and policies targeting adolescent nutrition are relatively new and coverage is low. To improve the nutritional status of this vulnerable population, additional evaluations of adolescent programming and surveillance data on adolescents are needed.

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“…The post test means score of experimental group was higher than the control group after the intervention. A study on nutritional status and effect of leaf concentrate supplementation on iron status of women (25-45 years) residing in Jaipur city found that highly significant increase in serum iron level and also the result highlighted increases in haematocrit and total iron binding capacity level 14 .…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: a randomised clinical trial

Cited by 20 publications

References 28 publications

Sustained effectiveness of weekly iron-folic acid supplementation and regular deworming over 6 years in women in rural Vietnam

Sustained effectiveness of weekly iron-folic acid supplementation and regular deworming over 6 years in women in rural Vietnam

Potential interventions targeting adolescent nutrition in Indonesia: a literature review

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