Impact of volumetric muscle loss injury on persistent motoneuron axotomy

Corona, Benjamin T.; Flanagan, Kate; Brininger, Christian M.; Goldman, Stephen M.; Call, Jarrod A.; Greising, Sarah M.

doi:10.1002/mus.26016

Cited by 49 publications

(46 citation statements)

References 41 publications

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“…2,19 The study by Corona and colleagues in this issue of the Journal provides an accurate characterization of neural dysfunction after VML injuries. 20 The authors employed a rat tibialis anterior muscle with a VML injury model to examine motor-neuron axotomy in correlation with the temporal neuromuscular and morphologic alterations due to the injury. These are crucial aspects for the understanding of pathogenesis.…”

Section: Usamentioning

confidence: 99%

“…Corona et al showed that the loss of force production in the acute phase could not be explained entirely by the loss of myofibers. 20 Instead, they suggest axotomy as a superimposed mechanism of functional failure, along with other factors, such as immune response and fibrosis. After the acute phase, the temporal dynamics of isometric torque loss represent another important parameter for the understanding of VML pathology.…”

Section: Usamentioning

confidence: 99%

“…The Corona et al findings suggest a reorganization and expansion of the motor units, implying neural plasticity in the transition between acute and chronic VML. 20 These are fundamental aspects if we are to correctly address therapies aimed to tap into the regenerative potential of neuromuscular tissues recovering from VML injuries. In particular, the authors suggest that each motor unit incorporates a greater number of muscle fibers after VML injuries, at least in their murine model.…”

Section: Usamentioning

confidence: 99%

“…These are fundamental aspects if we are to correctly address therapies aimed to tap into the regenerative potential of neuromuscular tissues recovering from VML injuries. In particular, the authors suggest that each motor unit incorporates a greater number of muscle fibers after VML injuries, at least in their murine model . In moving the field forward, it will be relevant to confirm these results in the clinical setting.…”

mentioning

confidence: 95%

“…Corona et al . showed that the loss of force production in the acute phase could not be explained entirely by the loss of myofibers . Instead, they suggest axotomy as a superimposed mechanism of functional failure, along with other factors, such as immune response and fibrosis.…”

mentioning

confidence: 99%

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Volumetric muscle loss: Including nerves into the equation

Quarta

2018

Muscle and Nerve

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Section: Usamentioning

confidence: 99%

Section: Usamentioning

confidence: 99%

Section: Usamentioning

confidence: 99%

mentioning

confidence: 95%

mentioning

confidence: 99%

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Volumetric muscle loss: Including nerves into the equation

Quarta

2018

Muscle and Nerve

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A Bioprinting Process Supplemented with In Situ Electrical Stimulation Directly Induces Significant Myotube Formation and Myogenesis

Kim

Lee

et al. 2021

Adv Funct Materials

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Electric field stimulation has supported biophysical and biological cues for tissue regeneration approaches to affect cell morphology, alignment, and even cellular phenotypes types. Here, an innovative bioprinting approach supported by in situ electrical stiumlation (E-printing) is used to fabricate a bioengineered skeletal muscle construct composed of human adipose stem cells and methacrylated decellularized extracellular matrix (dECM-Ma) derived from porcine muscle. To obtain highly ordered myofiber-like structures, various parameters of the printing process are optimized. The E-printed structure exhibits higher cell viability and fully aligned cytoskeleton than the conventionally printed cell-bearing structures, due to activation of voltage-gated ion channels that affect various signaling pathways. When using the E-printed structure, expression of myogenesis-related genes is upregulated by 1.9-2.5-fold higher than when using a dECM-Ma structure produced without electrical stimulation. Furthermore, when implanted into a rat model of volumetric muscle loss, the structure yields outstanding myogenesis relative to the conventionally bioprinted structure.

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Vascularized and Innervated Skeletal Muscle Tissue Engineering

Gilbert-Honick

Grayson

2019

Adv Healthcare Materials

125

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Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using tissue engineered muscle constructs in preclinical models of VML with a broad range of defect locations and sizes, tissue engineered construct characteristics, and outcome measures. Due to the complex vascular and neural anatomy within skeletal muscle, regeneration of functional vasculature and nerves is vital for muscle recovery following VML injuries. This review aims to summarize the current state of the field of skeletal muscle tissue engineering using 3D constructs for VML treatment with a focus on studies that have promoted vascular and neural regeneration within the muscle tissue post-VML.

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Impact of volumetric muscle loss injury on persistent motoneuron axotomy

Abstract: A ∼20% partial ablation of the TA muscle causes disproportionate damage across the motor unit acutely postinjury. Muscle Nerve 57: 799-807, 2018.

Cited by 49 publications

References 41 publications

Volumetric muscle loss: Including nerves into the equation

Volumetric muscle loss: Including nerves into the equation

A Bioprinting Process Supplemented with In Situ Electrical Stimulation Directly Induces Significant Myotube Formation and Myogenesis

Vascularized and Innervated Skeletal Muscle Tissue Engineering

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