Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: Detailed analysis of high-resolution electrocorticography using two mathematical approaches

Shimada, Sohei; Kunii, Naoto; Kawai, Kensuke; Matsuo, Tetsuji; Ishishita, Yohei; Ibayashi, Kenji; Saito, Nobuhito

doi:10.1016/j.clinph.2017.01.012

Cited by 23 publications

(16 citation statements)

References 38 publications

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“…Group analysis was employed to these earliest high-gamma sPCG sites, and it suggested that the areas under the curve of CCEPs at high-gamma STG and IFG sites were much larger (by 53% and 88% on average) compared to those at non-high-gamma sites within a given gyrus (p<0.001). As best appreciated in Video S5, CCEPs noted at distant high-gamma sites could not be attributed to volume conduction from the stimulated site (Shimada et al, 2017). Stimulation confined to high-gamma IFG sites was available only in patients #3 (Figures 7E and 7I) and #9.…”

Section: Resultsmentioning

confidence: 94%

Brain network dynamics in the human articulatory loop

Nishida

Korzeniewska

Crone

et al. 2017

Clinical Neurophysiology

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Objective The articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation. Methods We measured high-gamma activity70-110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming. We also conducted network analyses, and analyzed behavioral responses to cortical stimulation. Results Presentation of the initial tone elicited high-gamma augmentation bilaterally in the superior-temporal gyrus (STG) within 40 ms, and in the precentral and inferior-frontal gyri (PCG and IFG) within 160 ms after sound onset. During presentation of the second tone, high-gamma augmentation was reduced in STG but enhanced in IFG. The task requiring tone reproduction further enhanced high-gamma augmentation in PCG during and after sound presentation. Event-related causality (ERC) analysis revealed dominant flows within STG immediately after sound onset, followed by reciprocal interactions involving PCG and IFG. Measurement of cortico-cortical evoked-potentials (CCEPs) confirmed connectivity between distant high-gamma sites in the articulatory loop. High-frequency stimulation of precentral high-gamma sites in either hemisphere induced speech arrest, inability to control vocalization, or forced vocalization. Vocalization of tones was accompanied by high-gamma augmentation over larger extents of PCG. Conclusions Bilateral PCG rapidly and directly receives feed-forward signals from STG, and may promptly initiate motor planning including sub-vocal rehearsal for short-term buffering of auditory stimuli. Enhanced high-gamma augmentation in IFG during presentation of the second tone may reflect high-order processing of the tone sequence. Significance The articulatory loop employs sustained reciprocal propagation of neural activity across a network of cortical sites with strong neurophysiological connectivity.

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Section: Resultsmentioning

confidence: 94%

Brain network dynamics in the human articulatory loop

Nishida

Korzeniewska

Crone

et al. 2017

Clinical Neurophysiology

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“…Our results contradict with an earlier study, where VC in SPES was investigated using the root mean square (RMS) of the response [117]. They found that the RMS was proportional to the squared inverse of the distance to the stimulation pair and attributed this finding to VC.…”

Section: S33 Conclusion and Discussioncontrasting

confidence: 99%

“…Note that this phenomenon is not about VC of the electrical stimulation itself. The result could be that spurious local connectivity is found [117]. We investigated the influence of VC in 3.S3 and concluded that its effects in our SPES data are small.…”

Section: Methodological Issuesmentioning

confidence: 92%

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Computational modelling and electrical stimulation for epilepsy surgery

Hebbink¹

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“…) We excluded data from electrodes located within 25 mm of the stimulus site to rule out responses due to local U-fibers since our objective was to investigate the long-range CCEP responses. Volume-conducted responses, although rare in areas > 25 mm distant, were eliminated by visual inspection because they putatively reflect large responses just under the stimulus area (Shimada S et al 2017). We judged responses to be volume-conducted when the waveforms were almost invariant in shape and diminished steadily with distance from the stimulus site.…”

Section: Methodsmentioning

confidence: 99%

Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study

Nakae

Matsumoto

Kunieda

et al. 2019

Preprint

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AbstractIn the dual-stream model of language processing, the exact connectivity of the ventral stream to the anterior temporal lobe remains elusive. To investigate the connectivity among the inferior frontal gyrus (IFG) and the lateral part of the temporal and parietal lobes, we integrated spatiotemporal profiles of cortico-cortical evoked potentials (CCEPs) recorded intraoperatively from 14 patients who had had resective surgeries for brain tumor or epileptic focus. The 4D visualization of the combined CCEP data showed that the pars opercularis (Broca’s area) connected to the posterior temporal cortices and the supramarginal gyrus, while the pars orbitalis connected to the anterior lateral temporal cortices and the angular gyrus. Quantitative topographical analysis of CCEP connectivity confirmed an anterior-posterior gradient of connectivity from IFG stimulus sites to the temporal response sites. Reciprocality analysis indicated that the anterior part of the IFG is bi-directionally connected to the temporal or parietal area. The present study revealed that each IFG subdivision has a different connectivity to the temporal lobe with an anterior-posterior gradient and supports the classical connectivity concept of Dejerine that the frontal lobe is connected to the temporal lobe through the arcuate fasciculus and also a double-fan-shaped structure, anchored at the limen insulae.

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Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: Detailed analysis of high-resolution electrocorticography using two mathematical approaches

Cited by 23 publications

References 38 publications

Brain network dynamics in the human articulatory loop

Brain network dynamics in the human articulatory loop

Computational modelling and electrical stimulation for epilepsy surgery

Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study

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