Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

Lee, Yoon-Mi; Song, Byeng Chun; Yeum, Kyung‐Jin

doi:10.1155/2015/242709

Cited by 90 publications

(78 citation statements)

References 54 publications

(52 reference statements)

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“…Numerous factors can modulate the extent of oxidative stress and general inflammatory response [25,26,27,28]. The effect depends on the duration of ischaemia, the ischemic tissue volume and the general metabolic state of the organism (diabetes, drugs, chronic ischaemia).…”

Section: Discussionmentioning

confidence: 99%

Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model

Hardi

Nagy²,

Fazekas³

et al. 2016

J Vasc Res

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Acute kidney injury (AKI) remains an independent risk factor for mortality and morbidity after vascular surgery (affecting the renal arteries) or aortic surgery (requiring suprarenal aortic clamping). These types of vascular surgery produce renal ischemia/reperfusion (I/R) injury, a common cause of AKI. The present studies aimed at monitoring the course of renal I/R injury at the cellular level and investigating the efficacy of long-term preoperative and single-shot intraoperative administration of sodium pentosan polysulfate (PPS) to protect renal tissue from acute I/R injury both in native and diabetic kidneys in rats. Western blot analyses of the proapoptotic (bax) and antiapoptotic (bcl-2) signaling pathways, as well as the extent of DNA damage (phospho-p53), were performed. Oxidative stress followed upon the termination of malondialdehyde, reduced glutathione, thiol group, and superoxide dismutase plasma levels. Inflammatory changes were measured by the determination of serum tumor necrosis factor-α and interleukin-1 levels. Morphological changes were detected by histological examinations. Our results showed that the long-term administration of PPS has an advantage in reducing I/R kidney injury in diabetic rats, while high-dose, single-shot parenteral administration of PPS prior to revascularization might be useful in nondiabetic rats.

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Section: Discussionmentioning

confidence: 99%

Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model

Hardi

Nagy²,

Fazekas³

et al. 2016

J Vasc Res

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show abstract

“…In this context, Wong et al described apoptosis in neutrophils produced by exposure to sevoflurane in a dose-dependent manner, related to a ROS intracellular increase [23]. In contrast, Lee et al stated that volatile anesthetic agents, in patients who underwent minor surgeries, did not affect neither oxidative stress nor inflammation [24]. In our study, patients underwent video laparoscopic cholecystectomy, a moderate surgical procedure in which the exposure to volatile anesthetic agents did not induce apoptosis of immune cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Stress Response and Apoptosis on Leucocytes in TIVA versus Balanced Anesthesia

Soto¹,

Pignolo²,

Calero³

et al. 2017

OJApo

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Background: The aim of this study was to assess the stress response and apoptosis on leucocytes, in patients under two different anesthetics techniques. Methods: Thirty patients ASA I-II were prospectively randomized into two groups to receive either total intravenous anesthesia with propofolremifentanil (TIVA Group, n = 15) or balanced inhalation anesthesia with sevoflurane-remifentanil (BAL Group, n = 15). The hemodynamic response: systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) at different time points: baseline, after intubation, after skin incision and at the end of surgery, was measured along with plasma levels of lactate, glucose, cortisol and leucocytes count. The biomarkers of apoptosis (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes were evaluated at baseline, intraoperatively and two hours after surgery. Results: The study groups were comparable with respect to anthropometric data. No significant intergroup differences in SBP and DBP were revealed. The HR in the BAL group was lower after intubation (p = 0.007). In both groups, lactate, plasma glucose, cortisol and leucocytes count remained stable during surgery and two hours post-operatively. In the BAL group there were significant differences in Annexin V in neutrophils, baseline moment (p = 0.010). No significant differences were found in apoptosis markers (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes, at different time points. Conclusion: Both TIVA and BAL were effective in suppressing the surgical stress, without inducing apoptosis in immune cells, in patients undergoing VCL.

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“…Klinik pratikte volatil anesteziklerin uygulanmasın-dan sonra pulmoner problemlerin görülmesi, volatil anesteziklerin akciğer fonksiyonlarına etkisine ve akciğerde volatil anesteziklerin alımı ve eliminasyonuna olan merakı artırmıştır [1] .…”

Section: Introductionunclassified

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Acıl¹,

Kaçar²,

Uzundere³

et al. 2018

GKDA Derg

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Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

Cited by 90 publications

References 54 publications

Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model

Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model

Evaluation of Stress Response and Apoptosis on Leucocytes in TIVA versus Balanced Anesthesia

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

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