Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function

Yeung, Karla J. Au; Smith, Allen; Zhao, Aiping; Madden, Kathleen B.; Elfrey, Justin; Sullivan, Connor; Levander, Orville A.; Urban, Joseph F.; Shea‐Donohue, Terez

doi:10.1016/j.exppara.2004.12.015

Cited by 29 publications

(25 citation statements)

References 33 publications

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“…The requirement of antioxidant nutrients such as Se and vitamin E for resistance against nematode infections highlight the importance of redox balance in phagocytes (232). For example, mice fed torula yeast-based low Se diets exhibited decreased resistance to Heligmosomoides polygyrus compared with adequate Se diets (0.2 ppm Se) on secondary infection (11). In addition to killing of parasites, other effector functions are affected by Se-deficiency including cytokine and NO$ production (103).…”

Section: The Effects Of Se Intake On Camentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

682

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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Section: The Effects Of Se Intake On Camentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

682

496

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“…Previous work with mice established that deficiencies in selenium and/or vitamin E altered the normal physiological response and intestinal clearance of a parasitic nematode, Heligmosomoides polygyrus (1,49). A secondary H. polygyrus infection induced a potent T-helper cell 2 (Th2) immune (memory) response, and both single and double deficiencies in selenium and vitamin E delayed adult worm expulsion, increased fecundity (egg production), and impaired some, but not all, IL-4 receptor-dependent changes to the small intestine.…”

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confidence: 99%

The Pathogenicity of an EntericCitrobacter rodentiumInfection Is Enhanced by Deficiencies in the Antioxidants Selenium and Vitamin E

et al. 2011

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The pathogenesis of a Citrobacter rodentium infection was evaluated in mice fed diets with a single deficiency in either selenium or vitamin E or with a double deficiency in both selenium and vitamin E compared to mice on nutritionally adequate diets. Mice fed the selenium-and vitamin E-deficient diet for 6 weeks had increased loads of C. rodentium in the colon and spleen, which were not observed in mice fed either of the singly deficient diets or the adequate diet. Infected mice fed the doubly deficient diet had increased colon crypt hyperplasia and an influx of infiltrating cells along with gross changes to crypt architecture, including ulceration and denuding of the epithelial layer. Cytokine and chemokine mRNA levels in the colon were measured by real-time PCR. Expression of proinflammatory cytokines and chemokines was upregulated on day 12 after infection with C. rodentium in mice fed the doubly deficient diet compared to mice fed the control diet. Heme oxygenase 1, an enzyme upregulated by oxidative stress, also was more highly induced in infected mice fed the doubly deficient diet. Production of C. rodentium antigen-specific IgM and IgG antibodies was not affected by feeding the doubly deficient diet. The results indicated that selenium and vitamin E play an important role in host resistance and in the pathology induced by C. rodentium, an infection that mimics disease caused by common food-borne bacterial pathogens in humans.

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“…It increases the number of immunoglobulin-producing cells in the intestine (Kum et al, 2013). In the deficiency of it, resistance to helminth infections reduces (Au Yeung et al, 2005). On the other hand, it suppresses the activation (Shaik-Dasthagirisaheb et al, 2013) and proliferation of mast cells (Reiter et al, 2007;Kempná et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Rather, it increases lymphocyte proliferation (Puthpongsiriporn et al, 2001;Moriguchi, 1998) and the number of immunoglobulins producing cells (Kum et al, 2013). In its deficiency, it reduces resistance to helminth infections (Au Yeung et al, 2005).…”

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confidence: 99%

The effect of vitamin E on mast cells in small intestine of broilers under heat stress

Yıldız

Kum

Eren

2018

J Hellenic Vet Med Soc

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ABSTRACT. The aim of this study is to identify the effect of vitamin E (DL-α-tocopherol acetate) (300 IU/kg) on mast cells in the small intestine (duodenum, jejunum and ileum) under heat stress. In the study, 42 one-day-old Ross 308 male broiler chicks were used. The chicks were randomly separated into 3 groups as follows; control (22±2°C), heat stress (35°C, 5 hours/per day) and vitamin E (300 IU/kg/per day) + heat stress (35°C, 5 hours/per day). The applications of heat stress and vitamin E began on the fifteenth day and ended on the thirty-fifth day. Tissue samples were taken from animals in each group of four and five-week-old chickens. Tissue samples were fixed in BLA (Basic Lead Acetate) solution. The sections were stained with toluidine blue (TB) (pH 0.5) and alcian blue-critical electrolyte concentration (AB-CEC) (pH 5.8, 0.3 M MgCl 2 ) / Safranin O (SO) (pH 1.0) combined method. It was determined that increasing of the exposure duration to heat stress increased the number of mast cells in the small intestine of the boilers. Also, it was revealed that vitamin E reduced mast cell population under heat stress. Consequently, heat stress may play a role in the pathogenesis of small intestine-associated with disorders and the supplementation of vitamin E can contribute to regulate small intestine functions of broilers by decreasing mast cell proliferation and activation under heat stress.

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Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function

Cited by 29 publications

References 33 publications

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Pathogenicity of an EntericCitrobacter rodentiumInfection Is Enhanced by Deficiencies in the Antioxidants Selenium and Vitamin E

The effect of vitamin E on mast cells in small intestine of broilers under heat stress

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