Impact of Vitamin D Supplementation on Attention-Deficit Hyperactivity Disorder in Children

Elshorbagy, Hatem Hamed; Abdelghani, Waleed Elsayed; Suliman, Hany Abdelaziz; Al-Shokary, Ashraf Hamed; Abdulsamea, Sameh; Elsadek, Akram Elshafey; Maksoud, Yehia Hamed Abdel; Din, Dalia Mohamed Abd El-Hassib Nour El

doi:10.1177/1060028018759471

Cited by 31 publications

(19 citation statements)

References 27 publications

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“…ADHD has three symptoms including impulsivity, hyperactivity, and lack of attention (26,27). Recent studies have shown that serum vitamin D levels in ADHD children are signi cantly lower than healthy individuals (28,29), and it has also been shown that about 72% of children with ADHD have magnesium de ciency (30). Elshorbagy et al study showed that Vitamin D Supplementation in ADHD patients improve cognitive functions such as conceptual level, inattention, opposition, hyperactivity, and impulsivity domains compared to control group that these results con rm the ndings of our study (29).…”

Section: Discussionsupporting

confidence: 90%

“…Recent studies have shown that serum vitamin D levels in ADHD children are signi cantly lower than healthy individuals (28,29), and it has also been shown that about 72% of children with ADHD have magnesium de ciency (30). Elshorbagy et al study showed that Vitamin D Supplementation in ADHD patients improve cognitive functions such as conceptual level, inattention, opposition, hyperactivity, and impulsivity domains compared to control group that these results con rm the ndings of our study (29). Experimental studies in rats have shown that vitamin D de ciency impairs brain distortion, decreased release of neuronal growth factors, sensitivity to psychiatric stimulants (NMDA antagonist MK-801), and impaired attention processing (31), also they have increased impulsivity as well as a lack of inhibitory control (32).…”

Section: Discussionmentioning

confidence: 99%

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Positive Effect of Vitamin D and Magnesium Supplementation on Mental health Status of Attention-Deficit Hyperactive Children; A Randomized Double blind Controlled Clinical Trial

Hemamy

Pahlavani

Askari

et al. 2020

Preprint

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Background: Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in ADHD. The aim of this study is to determine the effect of Vitamin D and magnesium supplementation on mental health in children with ADHD.Method: This double‑blind, randomized controlled trial was performed on 66 ADHD children. participants were randomly allocated to receive both Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8 weeks. Strengths and difficulties questionnaire were used to evaluate children’s mental health at baseline and at the end of the study.Results: After 8 weeks of intervention, the serum levels of 25‑hydroxy‑Vitamin D3 and magnesium increased significantly in the intervention group compared with the control group. Also a significant decrease in changes of emotional problems (p=0.001), conduct problems (p=0.002), peer problems (p=0.001), prosocial score (p=0.007), total difficulties (p=0.001), externalizing score (p=0.001), and internalizing score (p=0.001) was seen in intervention group at the end of study.Conclusion: Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation during 8-week could improve the behavioral function and mental health in ADHD. Although further well-designed studies with a larger sample size are needed.the IRCT registration: IRCT2016030326886N1.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Positive Effect of Vitamin D and Magnesium Supplementation on Mental health Status of Attention-Deficit Hyperactive Children; A Randomized Double blind Controlled Clinical Trial

Hemamy

Pahlavani

Askari

et al. 2020

Preprint

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“…Some studies tested zinc [ 54 , 55 , 56 ] or vitamin D [ 25 , 57 , 58 ] ( Table 1 c). Zinc was used as sulfate [ 55 , 56 ] or glycinate [ 54 ] and vitamin D as generic [ 25 ] or D3 [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Some studies tested zinc [ 54 , 55 , 56 ] or vitamin D [ 25 , 57 , 58 ] ( Table 1 c). Zinc was used as sulfate [ 55 , 56 ] or glycinate [ 54 ] and vitamin D as generic [ 25 ] or D3 [ 57 , 58 ]. All studies provided micronutrients in addition to MPH [ 25 , 55 , 56 , 57 , 58 ] or dextroamphetamine [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

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Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, with environmental and biological causal influences. Pharmacological medication is the first choice in ADHD treatment; recently, many studies have concentrated on dietary supplementation approaches to address nutritional deficiencies, to which part of non-responses to medications have been imputed. This review aims to evaluate the efficacy of non-pharmacological supplementations in children or adolescents with ADHD. We reviewed 42 randomized controlled trials comprised of the following supplementation categories: polyunsaturated fatty acids (PUFAs), peptides and amino acids derivatives, single micronutrients, micronutrients mix, plant extracts and herbal supplementations, and probiotics. The reviewed studies applied heterogeneous methodologies, thus making it arduous to depict a systematic overview. No clear effect on single cognitive, affective, or behavioral domain was found for any supplementation category. Studies on PUFAs and micronutrients found symptomatology improvements. Peptides and amino acids derivatives, plant extracts, herbal supplementation, and probiotics represent innovative research fields and preliminary results may be promising. In conclusion, such findings, if confirmed through future research, should represent evidence for the efficacy of dietary supplementation as a support to standard pharmacological and psychological therapies in children and adolescents with ADHD.

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Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants

et al. 2021

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Impact of Vitamin D Supplementation on Attention-Deficit Hyperactivity Disorder in Children

Abstract: Vitamin D supplementation in children with ADHD may improve cognitive function.

Cited by 31 publications

References 27 publications

Positive Effect of Vitamin D and Magnesium Supplementation on Mental health Status of Attention-Deficit Hyperactive Children; A Randomized Double blind Controlled Clinical Trial

Positive Effect of Vitamin D and Magnesium Supplementation on Mental health Status of Attention-Deficit Hyperactive Children; A Randomized Double blind Controlled Clinical Trial

Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants

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