Impact of Vitamin D Supplementation on Covid-19 Vaccine Response and IgG Antibodies in Deficient Women: A randomized controlled trial

Abstract

Background: The immune response of COVID-19-vaccinated women with vitamin D deficiency was investigated by giving vitamin D supplementation. Methods: The study consisted of young volunteer women who completed two doses of COVID-19 vaccines and spent an average of more than 65 days. Participants in the D group (n=14 Pfizer-BioNTech, 2 Sinovac) were given 150,000 IU vitamin D supplements, and no supplement was given to the C group (n=14 Pfizer-BioNTech, 3 Sinovac). Results: When the last measurements were examined (W3) after vitamin D supplementation, it was observed that serum 25(OH) D levels regularly increased (p=0.001). It was observed that the W1 measurement of the D group was lower than those of the C group (P<0.001), and there was a significantly higher increase in the W2 measure (P<0.001). In addition, although there was no correlation between serum IgG and 25(OH) D in the D group at the beginning, a significant positive correlation was found in the final measurement (r=0.558, p=0.031). Conclusion: It was observed that the use of vitamin D significantly increased serum IgG levels compared to those who did not use vitamin D, depending on the duration, and in the long term, it was observed that it remained above the baseline. It has been determined that there is a positive and significant correlation between the last measurement of serum IgG and 25(OH) vitamin D levels during the use of vitamin D.

Unveiling the micronutrient‐immunity puzzle in inactivated COVID‐19 vaccination: A comprehensive analysis of circulating micronutrient levels and humoral responses in healthy adults

“…Similarly, vitamin D status appears to influence antibody production, with the study showing higher responses in those with sufficient levels (>50 nmol/L) compared to those with deficiency 18 . Notably, vitamin D supplementation in deficient individuals has been shown to positively correlate with IgG responses to COVID‐19 vaccines 50 . These findings underscore the importance of maintaining optimal micronutrient status for bolstering humoral responses after vaccination.…”

Can consumption of type 4 resistant starch reduce high blood glucose fluctuations? A randomised trial

“…Body mass index (BMI, in kg m À2 ) was calculated by dividing the weight (in kg) by the square of the height (in metres). It is known that this device is preferred for International Journal of Food Science and Technology 2024 anthropometric measurements and body weight classification in research (Cesur et al, 2023a). The data collection form was filled in after the measurements.…”

“…In addition, RS is digested by beneficial microorganisms in the large intestine and converted into short‐chain fatty acids (Kotancılar et al ., 2009). There are five types of RS: type 1 (found in the matrix of physically inaccessible food), type 2 (found in crystalline form in foods such as raw potatoes), type 3 (cooked and cooled potatoes, known as retrograde starch), type 4 (enzyme‐resistant starch (ERS)) and type 5 (composed of an amylose–lipid structure) (Kapelko et al ., 2012; Cesur et al ., 2023a).…”

Twin‐screw extrusion of vitamin D3/iron‐blend granules in corn and lentil composite flours: Stability, microstructure, and interaction of vitamin D3 with human osteoblast cells

“…VD3 has been proven to stimulate bone formation and mineralization using human osteoblasts (huOB) (van Driel et al., 2006); however, it does not have direct involvement, and only boosts the process of preparing the extracellular matrix for mineralization (van Driel et al., 2014). In addition to poor bone health, the deficiency of vitamin D (VD) has been associated with higher risks for several chronic illnesses, such as cancer, ischemic heart disease, type I diabetes, rheumatoid arthritis, multiple sclerosis, COVID‐19, and lethal malignancies (Cesur et al., 2023; D'Ecclesiis et al., 2022; de la Guía‐Galipienso et al., 2021). The primary source of VD3 is dermal synthesis from sunlight, and the exposure of 7‐dehydrocholesterol to ultraviolet B radiation from the sun converts it to VD3.…”