Impact of vitamin D insufficiency on the epicardial coronary flow velocity and endothelial function

Öz, Fahrettin; Çizgici, Ahmet Yaşar; Oflaz, Hüseyin; Elıtok, Ali; Karaayvaz, Ekrem Bilal; Mercanoğlu, Fehmi; Buğra, Zehra; Ömer, Beyhan; Adalet, Kâmil; Öncül, Aytaç

doi:10.1097/mca.0b013e328362b2c8

Cited by 47 publications

(32 citation statements)

References 29 publications

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“…Vitamin D insufficiency has been associated with higher endothelial activation and dysfunction [17]. According to some authors, vitamin D inadequacy in an adult, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical studies, it has been proposed that vitamin D deficiency and/or insufficiency is associated with impaired endothelial function [6]. Furthermore, several studies have shown an inverse correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and biomarkers of endothelial dysfunction in patients with hypertension, T2DM, coronary artery disease and stroke [15–17]. Vitamin D insufficiency is more prevalent in obese individuals [18–20].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ilinčić¹,

Stokić²,

Stosić³

et al. 2017

aoms

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IntroductionObesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors.Material and methodsFifty obese (body mass index (BMI) ≥ 30 kg/m2) non-diabetic adults (mean age: 36.2 ±5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age-matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects.ResultsThe mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 ±15.2 vs. 60.1 ±23.1 nmol/l; p < 0.001). In the obese group, sE-selectin (36.4 (32.1–47.2) vs. 32.4 (24.6–35.5) ng/ml, p < 0.05) and hsCRP (6.0 ±3.4 vs. 3.5 ±1.0 mg/l, p < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (β = –0.43; p < 0.001) and sE-selectin (β = –0.30; p = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group.ConclusionsVitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.

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“…Vitamin D insufficiency has been associated with higher endothelial activation and dysfunction [17]. According to some authors, vitamin D inadequacy in an adult, i.e.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ilinčić¹,

Stokić²,

Stosić³

et al. 2017

aoms

View full text Add to dashboard Cite

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“…Vitamin D level lower than 30 ng/mL has also been associated with reduced velocity of coronary blood flow, endothelial dysfunction, and subclinical atherosclerosis [20]. Vitamin D level lower than 20 ng/mL was detected in obese children with increased oxidative/nitrosative stress, markers of inflammation, and endothelial activation [21].…”

Section: Resultsmentioning

confidence: 99%

Ischemia modified albumin levels in vitamin D deficiency

Arslan¹

2017

Int J Med Biochem

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Research ArticleIschemia-modified albumin level in vitamin D deficiency V itamin D is a lipid-soluble vitamin, and its main function is to facilitate calcium absorption from the intestines. Through acting on calcium and phosphorus metabolism, vitamin D also regulates bone metabolism [1,2]. Following dietary intake or its synthesis in the skin upon exposure to sunlight, vitamin D is transported to the liver. The first hydroxylation step occurs in the liver at the carbon atom 25 position, forming 25(OH)D. This is the main circulating metabolite of vitamin D, and its serum concentration is regarded as an indicator of the vitamin D status of the body [3].Although the main function of vitamin D is the regulation of calcium and phosphorus metabolism and balancing bone metabolism, recent studies have suggested that vitamin D has other previously unknown roles as well. Among these new roles, providing beneficial effects to cardiovascular functions through acting on the vascular smooth muscle cells, myocardium, and endothelium is quite significant [2]. A reduced level of vitamin D is associated with increased cardiovascular mortality [4]. Furthermore, vitamin D plays a key role in the prevention of some cancer types, including colon, prostate, and lung cancer; autoimmune diseases, like multiple sclerosis, type 1 diabetes mellitus, and Crohn's disease; metabolic syndrome; and infectious diseases, such as tuberculosis [5,6].The association between vitamin D and extra-skeletal patholo-

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“…The response of the vessel diameter to reactive hyperemia was expressed as percentage change relative to the diameter immediately before cuff inflation. FMD was expressed as the percentage change from baseline in the brachial artery internal diameter following reactive hyperemia [18, 19]. The interobserver variability of the FMD measurement was 3.5% in our study.…”

Section: Methodsmentioning

confidence: 93%

Effect of Statins on Endothelial Function in Patients With Acute Coronary Syndrome: A Prospective Study Using Adhesion Molecules and Flow-Mediated Dilatation

Altun

2014

J Clin Med Res

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BackgroundAccumulating evidence suggests that inflammatory mechanisms play a central role in the development, progression and outcome of atherosclerosis. Recent evidence suggests that statins improve anti-inflammatory, anti-thrombotic and endothelial functions, along with their lipid-decreasing effects. We examined the effect of statins on endothelial function using biochemical markers of endothelial dysfunction and brachial artery flow-mediated dilatation (FMD).MethodsThirty male patients presenting with acute coronary syndrome (ACS) and 26 age-matched healthy control subjects aged 40 - 60 years who were not on any medication were enrolled in the study. The patient group was started on atorvastatin (40 mg/day) without consideration of their low-density lipoprotein (LDL)-cholesterol levels. Endothelin, sICAM and E-selectin from stored serum samples were measured using commercially available enzyme-linked immunosorbant assays (ELISAs). Endothelial function was assessed using brachial artery FMD.ResultsPrior to statin treatment, E-selectin, sICAM and endothelin levels, endothelial dysfunction markers, were 99.74 ± 34.67 ng/mL, 568.8 ± 149.0 ng/mL and 0.62 ± 0.33 fmol/mL, respectively in the patient group. E-selectin and sICAM levels were significantly higher in the patients than in the control subjects (P < 0.001); however, endothelin levels were not significantly different between groups. Statin treatment significantly reduced E-selectin and sICAM levels (P < 0.001); however, the decrease in endothelin levels was not statistically significant. %FMD values were significantly increased after statin treatment (P = 0.005), and levels of C-reactive protein (CRP), an inflammation marker, were significantly reduced.ConclusionOur results indicate that statins play an important role in treatment endothelial dysfunction by reducing adhesion of inflammatory cells.

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Impact of vitamin D insufficiency on the epicardial coronary flow velocity and endothelial function

Abstract: A strong association was found between VD insufficiency and the SCF phenomenon. In addition, VD insufficiency was associated with endothelial dysfunction and subclinical atherosclerosis. We believe that further studies are required to clarify the role of VD in patients with SCF.

Cited by 47 publications

References 29 publications

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ischemia modified albumin levels in vitamin D deficiency

Effect of Statins on Endothelial Function in Patients With Acute Coronary Syndrome: A Prospective Study Using Adhesion Molecules and Flow-Mediated Dilatation

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