Impact of vitamin D deficiency upon clinical presentation in nasal polyposis

Schlosser, Rodney J.; Soler, Zachary M.; Schmedes, Gregg W.; Storck, Kristina A.; Mulligan, Jennifer K.

doi:10.1002/alr.21274

Cited by 39 publications

(67 citation statements)

References 13 publications

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“…25VD 3 was inversely related to LM score, consistent with U.S. patients. 432 With regard to allergic status, Ozkara et al 897 found Turkish patients with concurrent CRSwNP and AR had significantly lower 1,25VD 3 than healthy controls. This effect was not seen in CRSwNP without AR, implying that allergy is a necessary condition.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

“…This work may partly explain the inverse correlation between 25VD 3 levels and bone erosion noted in some clinical studies. 426,432,433 Two statements can be made about VD 3 in CRSsNP:…”

Section: S55mentioning

confidence: 99%

“…Recently, in a retrospective analysis of 70 CRSwNP patients Schlosser et al 432 found 55% were 25VD 3 insufficient (<30 ng/mL) and an additional 30% were 25VD 3 deficient (<20 ng/mL). The lowest levels were found in African American patients with nearly 80% insufficient.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

“…This work may partly explain the inverse correlation between 25VD 3 levels and bone erosion noted in some clinical studies. 426,432,433 Two statements can be made about VD 3 in CRSsNP:…”

Section: S55mentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

Self Cite

554

888

View full text Add to dashboard Cite

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“…Vitamin D derivatives can prevent human nasal polyp-derived fibroblast proliferation in cultured cell models, and regulated on activation normal T cell-expressed and -secreted (RANTES) and matrix metalloproteinase 9 produced in keratinocytes and interleukin-8 production in normal human dermal fibroblasts [25–27]. Some recent studies indicated that vitamin D deficiency is related to disease severity and might be a key player in the etiopathology of chronic rhinosinusitis with NP [28–30]. Hu et al reported that polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations [31].…”

Section: Discussionmentioning

confidence: 99%

Is Nasal Polyposis Related to Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression?

et al. 2016

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BackgroundNasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP.Material/MethodsThe study included 46 subjects with NP (NP group) and 40 volunteers (control group). Nasal polyp tissue samples were taken from the NP group and nasal mucosa samples were taken from the control group. Levels of VDR gene expression in the tissue samples were assessed using the real-time polymerase chain reaction (RT-PCR) method.ResultsMean serum 25(OH)D levels were 13.38±14.08 ng/ml in the NP group and 10.57±6.44 ng/ml in the control group (p=0.249). VDR gene expression was present in 17.5% of the NP group and 3.3% of the control group, and the difference between the 2 groups was statistically significant (likelihood ratio χ2=3.887; p=0.049).ConclusionsThis is the first study to assess levels of VDR gene expression in subjects with NP. Our results suggest that VDR gene expression may be associated with the pathogenesis or progression of NP.

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“…Low levels of plasma vitamin D 3 have been reported in both adults and children with CRSwNP and allergic fungal rhinosinusitis compared with CRSsNP patients and controls [39,41]. Lower levels of vitamin D 3 have been associated with increased values of the Lund-Mackay CT score in patients with CRSwNP [42].…”

Section: Nutrition Habits and Occupational Factorsmentioning

confidence: 97%

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

López-Chacón

Mullol

Pujols

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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Impact of vitamin D deficiency upon clinical presentation in nasal polyposis

Abstract: VD3 insufficiency/deficiency is common in CRSwNP patients, especially those of African American race. Lower levels of VD3 are associated with worse LMS on CT. The role of VD3 in CRSwNP warrants further investigation.

Cited by 39 publications

References 13 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Is Nasal Polyposis Related to Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression?

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

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