Impact of Visceral Obesity on Structural and Functional Alterations of Gut Microbiota in Polycystic Ovary Syndrome (PCOS): A Pilot Study Using Metagenomic Analysis

Bai, Xuefeng; Ma, Jiangxin; Wu, Xiaohong; Qiu, Lingling; Huang, Rongfu; Zhang, Haibin; Huang, Huibin; Chen, Xiaoyu

doi:10.2147/dmso.s388067

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…The similar results were presented by M. Insenser et al The scientists found lower α diversity in PCOS women, and low β was determined in obese PCOS women; increased abundance of Catenibacterium and Kandleria genera was also established by PCOS [62]. Another study confirmed the high diversity of Bacteriodetes in PCOS women and patients with visceral obesity, it was established that Prevotella, Magamonas and Dialister genera positively associated with metabolic parameters (p<0.05), while low abundance of Phascolarctobacterium and Neisseria generanegatively correlated [63].…”

Section: г і н е к о л о г і яmentioning

confidence: 85%

The modern pathogenetic challenges of polycystic ovary syndrome

Pakharenko,

Zhylka,

Shcherbinska

et al. 2024

RHW

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Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women of reproductive age. In the pathogenesis of its development a great importance is paid to the hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS is accompanied by infertility, cardiovascular risks, diabetes mellitus.The article is devoted to a review of modern scientific literature about the last researches devoted to the mechanisms of metabolic disorders which are connected with insulin resistance, overweight and obesity, also, with psychological disturbance and stress. The article describes the specific of psychological conditions in PCOS patients. On the basis of the analyzed scientific publications the connection between hormonal disbalance, psychological disorders, overweight, obesity and lipidogram parameters is presented.Also, the researches about gut and vaginal microbiota are described in this paper. The last studies demonstrate the significant changes of human microbiome in the development and course of polycystic ovary syndrome. The article presents the concepts of the difference in the composition of the gut and vagina microbiota in women with this neuroendocrine syndrome.The pathogenetic mechanisms of the role of the microbiota in the processes of PCOS pathogenesis, namely, the regulation of the immune response and inflammation processes in this pathology, are described. It has been shown that in women with PCOS there are differences in the microflora composition of the intestines, manifested by a decreased concentration of Lactobacillus and the presence of a variety of other microorganisms compared to the healthy women.Thus, the main pathogenetic links of PCOS development are closely connected with each other. That is why multimodal approaches for study of PCOS and for management of the patients with PCOS are extremely important.

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Section: г і н е к о л о г і яmentioning

confidence: 85%

The modern pathogenetic challenges of polycystic ovary syndrome

Pakharenko,

Zhylka,

Shcherbinska

et al. 2024

RHW

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“…There have been reports about the pathogenic activity and antibiotic resistance of the genus Kluyvera , although it is generally considered as commensal bacteria in respiratory, urinary, and intestinal tract ( Lee et al, 2019 ). Interestingly, in gut samples, Kluyvera was found to correlate negatively with 25-hydroxy vitamin D in obese women with polycystic ovary syndrome ( Bai et al, 2023 ), highlightening the potential significance of Kluyvera in different disease contexts and warranting further investigation into its role in obesity-related conditions. Finding genus Kluyvera enriched in the group of Mexican patients with in obese>I, it is interesting to expand its study.…”

Section: Discussionmentioning

confidence: 99%

Cytokine and microbiota profiles in obesity-related hypertension patients

Aguirre-García,

Amedei,

Hernández-Ruiz

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension.

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“…However, out of the four responding taxa within this family, we were only able to identify the Mediterraneibacter genus. Previous research has found that Mediterraneibacter is associated with host obesity in women with polycystic ovary syndrome ( 65 ) and that is able to produce aldehyde alcohols which are considered harmful to the host ( 63 ), whereas its role in fiber fermentation has not been described. Together, the identification of both positively and negatively responding clades provide candidates for investigating the mechanistic links between a fiber-rich diet, the metabolic outputs of fiber degradation, and intestinal health.…”

Section: Discussionmentioning

confidence: 99%

Short-term dietary fiber interventions produce consistent gut microbiome responses across studies

Rodriguez,

Isobe,

Martiny

2023

Preprint

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Background The composition of the human gut microbiome varies tremendously among individuals, making the effects of dietary or treatment interventions difficult to detect and characterize. The consumption of fiber is important for gut health, yet the specific effects of increased fiber intake on the gut microbiome vary across studies. The variation in study outcomes might be due to inter-individual (or inter-population) variation or to the details of the interventions including the types of fiber, length of study, size of cohort, and molecular approaches. Thus, to identify consistent fiber-induced responses in the gut microbiome of healthy individuals, we re-analyzed 16S rRNA sequencing data from 21 dietary fiber interventions from 12 human studies, which included 2564 fecal samples from 538 subjects across all interventions.Results Short-term increases in dietary fiber consumption resulted in highly consistent gut microbiome responses across studies. Increased fiber consumption explained an average of 1.5% of compositional variation (versus 82% of variation attributed to the individual), reduced alpha diversity, and resulted in phylogenetically conserved responses in relative abundances among bacterial taxa. Additionally, we identified bacterial clades, at approximately the genus level, that were highly consistent in their response (increasing or decreasing in their relative abundance) to dietary fiber interventions across the studies.Conclusions Our study is an example of the power of synthesizing and reanalyzing microbiome data from many intervention studies. Despite high inter-individual variation of the composition of the human gut microbiome, dietary fiber interventions cause a consistent response both in the degree of change as well as the particular taxa that respond to increased fiber.

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Impact of Visceral Obesity on Structural and Functional Alterations of Gut Microbiota in Polycystic Ovary Syndrome (PCOS): A Pilot Study Using Metagenomic Analysis

Cited by 6 publications

References 34 publications

The modern pathogenetic challenges of polycystic ovary syndrome

The modern pathogenetic challenges of polycystic ovary syndrome

Cytokine and microbiota profiles in obesity-related hypertension patients

Short-term dietary fiber interventions produce consistent gut microbiome responses across studies

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