Impact of Viral Etiology on Postoperative De Novo Recurrence After Hepatectomy for Hepatocellular Carcinoma in Cirrhotic Patients

Sasaki, Kazunari; Shindoh, Junichi; Nishioka, Yujiro; Margonis, Georgios Antonios; Sugawara, Toshitaka; Andreatos, Nikolaos; Hashimoto, Masaji; Pawlik, Timothy M.

doi:10.1007/s11605-016-3344-3

Cited by 24 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are not many differences compared to the recurrence pattern of the untreated group in the present study. HCV-associated hepatocellular carcinoma tends to develop multicentric carcinogenesis more frequently than other causes of hepatocellular carcinoma [31,32]. In other AST aspartate aminotransferase, ALT alanine aminotransferase, PLT platelets, PT prothrombin time, T.Bil total bilirubin, Alb albumin, AFP alpha-fetoprotein, HCC hepatocellular carcinoma, DAA direct-acting antiviral agent J Gastroenterol words, eradication of HCV by DAA suppresses multiple recurrences after HCC treatment.…”

Section: Discussionmentioning

confidence: 99%

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria

et al. 2020

View full text Add to dashboard Cite

Background The effects of direct-acting antivirals (DAAs) on survival and recurrence rates after curative hepatocellular carcinoma (HCC) treatment in patients with hepatitis C virus (HCV) infection remain controversial. Methods This retrospective, multicenter study involved Child–Pugh class A patients within the Milan criteria who had a first diagnosis of HCC and survived 6 months or longer after undergoing hepatectomy or radiofrequency ablation (RFA). The DAA-treated group (DAA group) included 56 patients, and the DAA-untreated group (untreated group) included 261 patients. The study was conducted using the propensity score-matched (1:2) DAA group and untreated group, 56 and 112 patients, respectively. Results The survival rate at 48 months in the DAA group and the untreated group was 91.0% and 68.7%, respectively, showing significantly better survival in the DAA group (HR: 0.33; 95% CI 0.13–0.84; p = 0.021). The recurrence rate at 48 months was 36.7% and 66.7%, respectively, showing a significantly lower recurrence rate in the DAA group (HR, 0.46; 95% CI 0.27–0.77; p = 0.003). The median albumin–bilirubin (ALBI) score at 3 years post-HCC treatment was − 2.84 in the DAA group and − 2.34 in the untreated group. The ALBI score showed a significant improvement from baseline to 3 years post-HCC treatment (p = 0.001), whereas that in the untreated group showed a significant decline (p = 0.040). Conclusions DAAs after HCC treatment prevents deterioration of hepatic functional reserve and significantly improves both recurrence and survival rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Anti-HBV therapy Although the advance in the treatment of HCC provides opportunities for curative treatment, a high incidence of recurrence, up to 50% at 5 years after curative treatment, was observed in patients with underlying chronic HBV infection [104] . Therefore, it is urgent to identify risk factors associated with HCC recurrence and develop tertiary prevention for HBV-related HCC after curative treatment.…”

Section: Tertiary Preventionmentioning

confidence: 99%

Prevention of hepatitis B virus-related hepatocellular carcinoma

Kao¹

2021

View full text Add to dashboard Cite

“…The high rate of recurrence remains a challenge for hepatic surgeons. Risk factors related with tumour characteristics are significantly related to early HCC recurrence, but the impact of viral status on recurrence is unclear, and some studies did not identify any role for hepatitis B viral status on prognosis, whilst other studies suggested that the presence of HBeAg was significantly correlated with prognosis . Propensity score matching analysis has been widely used in patients with HCC .…”

Section: Introductionmentioning

confidence: 99%

The prognostic significance of serum HBeAg on the recurrence and long‐term survival after hepatectomy for hepatocellular carcinoma: A propensity score matching analysis

Shen

Liu

et al. 2018

Journal of Viral Hepatitis

View full text Add to dashboard Cite

The effects of serum hepatitis B e antigen (HBeAg) on the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy remain controversial. Our aim was to explore the prognostic significance of serum HBeAg on the prognosis of patients with HCC using a propensity matching model. Between January 2009 and March 2015, 953 patients with HCC who underwent hepatectomy in West China Hospital were analysed. Propensity matching analysis was applied, and survival analysis was performed using the Kaplan-Meier method. Risk factors were identified by the Cox proportional hazards model. All patients with HCC were classified into an HBeAg(-) group (n = 775, 81.3%) or an HBeAg(+) group (n = 178, 18.7%). Patients with positive serum HBeAg had poorer recurrence-free survival and overall survival before and after propensity matching. Similar results were found in patients within the Milan criteria. For patients beyond the Milan criteria, the HBeAg(+) group had poor overall survival before and after propensity matching. In term of recurrence-free survival, there was no statistically significant impact after propensity matching (P = .055), although there was a trend for HBeAg(+) patient to have reduced recurrence-free survival. Positive serum HBeAg, positive HBV-DNA load, largest tumour size, multiple tumours, microvascular invasion and a high serum level of preoperative alpha-fetoprotein were risk factors for recurrence. Our propensity model confirmed that positive serum HBeAg had a negative impact on the recurrence and long-term survival irrespective of tumour stages. HBeAg seroconversion might be beneficial for reducing the rate of recurrence.

show abstract

Impact of Viral Etiology on Postoperative De Novo Recurrence After Hepatectomy for Hepatocellular Carcinoma in Cirrhotic Patients

Abstract: HCV-related LC was associated with a higher postoperative de novo carcinogenesis than HBV-related LC. Establishment of different treatment algorithms as well as follow-up surveillance protocols stratified by viral etiology may be warranted.

Cited by 24 publications

References 33 publications

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria

Prevention of hepatitis B virus-related hepatocellular carcinoma

The prognostic significance of serum HBeAg on the recurrence and long‐term survival after hepatectomy for hepatocellular carcinoma: A propensity score matching analysis

Contact Info

Product

Resources

About