Impact of Ventricular Geometric Characteristics on Myocardial Stiffness Assessment Using Shear-Wave Velocity in Healthy Children and Young Adults

Malik, Aqsa; Baranger, Jérôme; Nguyen, Minh Bao; Slorach, Cameron; Wu, Hui; Villalobos-Lizardi, José Carlos; Venet, Maelys; Friedberg, Mark K.; Mertens, Luc; Villemain, Olivier

doi:10.1016/j.echo.2023.02.012

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…However, we believe the guiding effect in the current study is minimal as the wall thickness (9 mm in baseline, see Table 1 ) is larger than (i) the wavelength (± 6.5 mm on average in Fig. 2 ), which is the typical criterion for the existence of guided waves, and (ii) the recently presented cut-off of 4.4 mm (age > 1 month) by Malik et al 30 for which diastolic speed no longer depended on wall thickness in a multivariate linear analysis for their (unreported) shear wave frequencies.…”

Section: Discussionmentioning

confidence: 54%

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Caenen,

Keijzer,

Bézy

et al. 2023

Sci Rep

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Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure–volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure–volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure–volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury.

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Section: Discussionmentioning

confidence: 54%

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Caenen,

Keijzer,

Bézy

et al. 2023

Sci Rep

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“…16 Associado a tais fatores técnicos, o tecido cardíaco é essencialmente anisotrópico, com diferentes camadas, de paredes finas e com movimentação própria, 17 variáveis que podem influenciar adicionalmente na velocidade de propagação da onda de cisalhamento. Além disso, as alterações geométricas já demonstraram impacto nessas medidas, 18 bem como aumentos de pré-carga. 17 Esses fatores mecânicos limitam a utilização do módulo de Young para obtenção da rigidez miocárdica, pois essa equação não os considera.…”

Section: Desafios Para Sua Utilizaçãounclassified

Papel da Elastografia por Ondas de Cisalhamento na Avaliação da Rigidez Miocárdica nas Diversas Miocardiopatias

Fernandes,

Santorio,

Pereira

et al. 2023

Arq Bras Cardiol: Imagem cardiovasc.

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O ecocardiograma é fundamental para o diagnóstico e tratamento das doenças cardiovasculares. A avaliação da função diastólica do ventrículo esquerdo constitui um grande desafio, sendo utilizadas várias técnicas ultrassonográficas conhecidas, tais como o Doppler pulsátil do fluxo mitral, o Doppler tecidual e o strain miocárdico, com o objetivo de estimar de forma não invasiva a pressão de enchimento do átrio esquerdo. Apesar de amplamente disponível, essa abordagem possui várias limitações e não representa de fato as propriedades intrínsecas do músculo cardíaco. Nesse contexto, a elastografia cardíaca surge como uma forma de estimar a rigidez miocárdica de forma não invasiva, ao estudar a velocidade de propagação de ondas de cisalhamento no tecido cardíaco. A elastografia já é amplamente utilizada na avaliação da rigidez de outros tecidos, como tireoide, fígado e mama. No âmbito da avaliação cardiológica, essa técnica já foi empregada com sucesso em doenças como amiloidose cardíaca e cardiomiopatia hipertrófica. Este artigo visa revisar os principais conceitos associados a essa técnica promissora e expor as experiências publicadas de serviços nacionais e internacionais.

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“…16 Associated with such technical factors, cardiac tissue is essentially anisotropic, with different layers, thin walls, and its own movement patterns, 17 variables that can influence shear wave propagation speed. Furthermore, it has been shown that both geometric changes 18 and increased preload 17 affect…”

Section: Challenges To Using Shear Wave Elastographymentioning

confidence: 99%

Role of Shear Wave Elastography in the Assessment of Myocardial Stiffness in Various Cardiomyopathies

Fernandes,

Santorio,

Pereira

et al. 2023

ABC Imagem Cardiovascular

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Echocardiography is essential for the diagnosis and treatment of cardiovascular disease. Assessing left ventricle diastolic function is a major challenge, and several wellknown ultrasound techniques, such as pulsed Doppler for mitral flow, tissue Doppler, and myocardial strain, are used to non-invasively estimate left atrial filling pressure. Although widely available, this approach has several limitations and does not truly represent the intrinsic properties of the cardiac muscle. However, cardiac elastography can be studied noninvasively by estimating myocardial stiffness through shear wave propagation speed in cardiac tissue. Elastography is already widely used to assess stiffness in other tissue types, such as thyroid, liver, and breast. In the context of cardiological assessment, this technique has already been successfully used in diseases such as cardiac amyloidosis and hypertrophic cardiomyopathy. This article aims to review the main concepts of this promising technique and present the published experiences of national and international services.

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Impact of Ventricular Geometric Characteristics on Myocardial Stiffness Assessment Using Shear-Wave Velocity in Healthy Children and Young Adults

Cited by 8 publications

References 34 publications

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Papel da Elastografia por Ondas de Cisalhamento na Avaliação da Rigidez Miocárdica nas Diversas Miocardiopatias

Role of Shear Wave Elastography in the Assessment of Myocardial Stiffness in Various Cardiomyopathies

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